@import"https://fonts.googleapis.com/css2?family=Caveat:wght@500;600&family=Poppins:wght@400;500;600;700;800;900&display=swap";#substance-matrix-app{--pms-primary: #0047d8;--pms-primary-soft: #dbe8ff;--pms-secondary: rgba(0, 71, 216, .64);--pms-accent: #00d690;--pms-background: #edf4ff;--pms-surface: #f2f8ff;--pms-text: #0c2a48;--pms-muted: rgba(12, 42, 72, .7);--pms-warning: #f4a900;--pms-warning-soft: #fff0bf;--pms-critical: #d60046;--pms-critical-soft: #ffe0eb;--pms-glass: rgba(255, 255, 255, .58);--pms-border: rgba(255, 255, 255, .55);--pms-class-substance: #00d690;--pms-class-medicament: #9000d6;--pms-funky-green: #00d690;--pms-funky-violet: #9000d6;--pms-funky-pink: #d60046;--pms-shadow: 0 4px 12px rgba(0, 71, 216, .1);color:var(--pms-text);font-family:Poppins,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,sans-serif}#substance-matrix-app *,#substance-matrix-app *:before,#substance-matrix-app *:after{box-sizing:border-box}#substance-matrix-app button,#substance-matrix-app a{font:inherit}#substance-matrix-app button{border:0}#substance-matrix-app svg{display:block;width:1em;height:1em}#substance-matrix-app .pms-shell{position:relative;overflow:hidden;background:var(--pms-background)}#substance-matrix-app[data-pms-background=none] .pms-shell{background:transparent}#substance-matrix-app .pms-bg-doodles{position:fixed;top:0;right:0;bottom:0;left:0;z-index:0;overflow:hidden;pointer-events:none}#substance-matrix-app .pms-bg-doodle{position:fixed;display:grid;place-items:center;color:#fffffffa;background:#2d51a029;border-radius:999px;filter:drop-shadow(0 5px 12px rgba(45,81,160,.2))}#substance-matrix-app .pms-bg-doodle svg{width:62%;height:62%;stroke-width:2}#substance-matrix-app .pms-bg-doodle-zap-1{top:10vh;left:5vw;width:25px;height:25px;transform:rotate(-12deg)}#substance-matrix-app .pms-bg-doodle-sparkle-1{top:12vh;left:86vw;width:24px;height:24px;opacity:.9;transform:rotate(10deg)}#substance-matrix-app .pms-bg-doodle-zap-2{top:22vh;left:92vw;width:23px;height:23px;opacity:.88;transform:rotate(15deg)}#substance-matrix-app .pms-bg-doodle-sparkle-2{top:28vh;left:7vw;width:21px;height:21px;opacity:.86;transform:rotate(-8deg)}#substance-matrix-app .pms-bg-doodle-sparkle-3{top:40vh;left:84vw;width:26px;height:26px;opacity:.9;transform:rotate(-14deg)}#substance-matrix-app .pms-bg-doodle-zap-3{top:50vh;left:9vw;width:22px;height:22px;opacity:.86;transform:rotate(12deg)}#substance-matrix-app .pms-bg-doodle-sparkle-4{top:59vh;left:90vw;width:22px;height:22px;opacity:.84;transform:rotate(8deg)}#substance-matrix-app .pms-bg-doodle-zap-4{top:68vh;left:14vw;width:23px;height:23px;opacity:.86;transform:rotate(-18deg)}#substance-matrix-app .pms-bg-doodle-sparkle-5{top:76vh;left:82vw;width:21px;height:21px;opacity:.84;transform:rotate(16deg)}#substance-matrix-app .pms-bg-doodle-zap-5{top:86vh;left:4vw;width:22px;height:22px;opacity:.84;transform:rotate(9deg)}#substance-matrix-app .pms-bg-doodle-sparkle-6{top:88vh;left:88vw;width:24px;height:24px;opacity:.86;transform:rotate(-10deg)}#substance-matrix-app .pms-bg-doodle-sparkle-7{top:17vh;left:18vw;width:20px;height:20px;opacity:.8;transform:rotate(22deg)}#substance-matrix-app .pms-bg-doodle-zap-6{top:33vh;left:78vw;width:21px;height:21px;opacity:.82;transform:rotate(-12deg)}#substance-matrix-app .pms-bg-doodle-sparkle-8{top:72vh;left:26vw;width:22px;height:22px;opacity:.82;transform:rotate(-18deg)}#substance-matrix-app .pms-bg-doodle-zap-7{top:6vh;left:73vw;width:22px;height:22px;opacity:.84;transform:rotate(18deg)}#substance-matrix-app .pms-bg-doodle-sparkle-9{top:92vh;left:42vw;width:21px;height:21px;opacity:.8;transform:rotate(8deg)}@media(max-width:520px){#substance-matrix-app .pms-bg-doodle-zap-2,#substance-matrix-app .pms-bg-doodle-sparkle-4{left:82vw}#substance-matrix-app .pms-bg-doodle-sparkle-1,#substance-matrix-app .pms-bg-doodle-sparkle-6{left:78vw}}#substance-matrix-app .pms-view{position:relative;z-index:1;width:min(100%,512px);margin:0 auto;padding:48px 24px 80px}#substance-matrix-app .pms-version-home{position:relative;z-index:1;width:min(100%,760px);margin:0 auto;padding:56px 24px 80px}#substance-matrix-app .pms-version-header{max-width:560px;margin-bottom:28px}#substance-matrix-app .pms-version-header h1{margin-bottom:12px;color:var(--pms-text);font-size:2rem;font-weight:900;line-height:1.1}#substance-matrix-app .pms-version-header p{color:var(--pms-muted);font-size:1rem;font-weight:500;line-height:1.45}#substance-matrix-app .pms-version-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:16px}#substance-matrix-app .pms-version-archive{display:grid;gap:14px;margin-top:28px}#substance-matrix-app .pms-version-archive h2{margin:0;color:#0c2a48b8;font-size:.92rem;font-weight:900;letter-spacing:0}#substance-matrix-app .pms-version-card{display:grid;min-height:190px;cursor:pointer;align-content:start;gap:10px;padding:22px;color:var(--pms-text);border:1px solid var(--pms-border);border-radius:24px;background:var(--pms-glass);box-shadow:var(--pms-shadow);text-align:left;transition:transform .18s ease,background .18s ease,border-color .18s ease}#substance-matrix-app .pms-version-card.is-featured{min-height:150px;border-color:color-mix(in srgb,var(--pms-primary) 34%,#fff);background:#fff}#substance-matrix-app .pms-version-card:hover,#substance-matrix-app .pms-version-card:focus-visible{transform:translateY(-2px);border-color:color-mix(in srgb,var(--pms-primary) 28%,#fff);background:#ffffffb8}#substance-matrix-app .pms-version-card span{color:var(--pms-primary);font-size:.75rem;font-weight:900;line-height:1}#substance-matrix-app .pms-version-card strong{display:block;font-size:1.25rem;font-weight:900;line-height:1.15}#substance-matrix-app .pms-version-card p{color:#0c2a48ad;font-size:.9375rem;font-weight:600;line-height:1.45}#substance-matrix-app .pms-version-back,#substance-matrix-app .pms-back{display:inline-flex;align-items:center;gap:6px;margin-bottom:22px;cursor:pointer;color:#0c2a489e;background:transparent;border:1px solid var(--pms-border);border-radius:999px;padding:8px 12px;font-size:.75rem;font-weight:800}#substance-matrix-app .pms-version-back svg,#substance-matrix-app .pms-back svg{width:15px;height:15px}#substance-matrix-app .pms-flow-nav{display:flex;flex-wrap:wrap;align-items:center;justify-content:space-between;gap:10px;margin-bottom:22px}#substance-matrix-app .pms-flow-nav .pms-version-back,#substance-matrix-app .pms-flow-nav .pms-back{margin-bottom:0}#substance-matrix-app .pms-back{color:var(--pms-primary);background:#ffffffb8;border-color:#2d51a038}#substance-matrix-app .pms-header{margin-bottom:22px}#substance-matrix-app .pms-brand{display:flex;align-items:center;gap:12px;margin-bottom:22px}#substance-matrix-app .pms-brand-mark,#substance-matrix-app .pms-result-mark{display:grid;width:48px;height:48px;place-items:center;color:#fff;background:var(--pms-primary);border-radius:18px;box-shadow:0 12px 28px #0047d857}#substance-matrix-app .pms-brand-mark svg{width:28px;height:28px}#substance-matrix-app h1,#substance-matrix-app h2,#substance-matrix-app h3,#substance-matrix-app p{margin:0}#substance-matrix-app h1{font-size:1.5rem;font-weight:900;line-height:1.15}#substance-matrix-app .pms-header p{color:var(--pms-muted);font-size:1.125rem;font-weight:400;line-height:1.35}#substance-matrix-app .pms-header .pms-entry-disclaimer{max-width:420px;margin-top:12px;color:#0c2a4894;font-size:.8125rem;font-weight:500;line-height:1.45}#substance-matrix-app .pms-prevention,#substance-matrix-app .pms-selection-tray,#substance-matrix-app .pms-step-panel,#substance-matrix-app .pms-single-panel,#substance-matrix-app .pms-picker{border:1px solid var(--pms-border);background:var(--pms-glass);box-shadow:var(--pms-shadow)}#substance-matrix-app .pms-prevention{display:grid;grid-template-columns:34px 1fr;gap:12px;align-items:start;margin-bottom:18px;padding:14px 16px;border-radius:18px}#substance-matrix-app .pms-prevention p{color:#0c2a48ad;font-size:.8125rem;font-weight:500;line-height:1.45}#substance-matrix-app .pms-prevention-icon{display:grid;width:34px;height:34px;place-items:center;color:var(--pms-primary);background:var(--pms-primary-soft);border-radius:12px}#substance-matrix-app .pms-prevention-icon svg{width:18px;height:18px}#substance-matrix-app .pms-selection-tray,#substance-matrix-app .pms-step-panel,#substance-matrix-app .pms-picker{display:grid;gap:14px;margin-bottom:18px;padding:16px;border-radius:18px}#substance-matrix-app .pms-selection-tray{gap:20px;padding:24px}#substance-matrix-app .pms-selection-head,#substance-matrix-app .pms-picker-head{display:flex;align-items:center;justify-content:flex-start;gap:12px}#substance-matrix-app .pms-selection-head{justify-content:space-between}#substance-matrix-app .pms-picker-head{flex-wrap:wrap}#substance-matrix-app .pms-selection-head h2,#substance-matrix-app .pms-picker-head h2{color:var(--pms-text);font-size:.875rem;font-weight:900;line-height:1.2}#substance-matrix-app .pms-selection-head h2{font-size:1rem;line-height:1.25}#substance-matrix-app .pms-step-panel{border-radius:18px}#substance-matrix-app .pms-progress{position:relative;display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:8px;margin:0;padding:0 0 2px;list-style:none}#substance-matrix-app .pms-progress:before,#substance-matrix-app .pms-progress:after{content:"";position:absolute;top:13px;left:calc(25% + 16px);right:calc(25% + 16px);height:1px;border-radius:999px}#substance-matrix-app .pms-progress:before{background:#0c2a4829}#substance-matrix-app .pms-progress:after{background:#2d51a094;transform:scaleX(0);transform-origin:left;transition:transform .18s ease}#substance-matrix-app .pms-progress.has-first:after,#substance-matrix-app .pms-progress.has-second:after{transform:scaleX(1)}#substance-matrix-app .pms-progress-step{position:relative;z-index:1;display:flex;min-width:0;align-items:center;gap:7px;color:#0c2a489e}#substance-matrix-app .pms-progress-step:nth-child(2){justify-content:flex-end}#substance-matrix-app .pms-progress-step.is-active,#substance-matrix-app .pms-progress-step.is-complete{color:var(--pms-text)}#substance-matrix-app .pms-progress-step.is-waiting{color:#0c2a486b}#substance-matrix-app .pms-progress-marker{display:grid;width:26px;height:26px;flex:0 0 auto;place-items:center;color:var(--pms-primary);background:#ffffffa8;border:1px solid rgba(45,81,160,.16);border-radius:999px;font-size:.75rem;font-weight:900}#substance-matrix-app .pms-progress-step.is-active .pms-progress-marker,#substance-matrix-app .pms-progress-step.is-complete .pms-progress-marker{color:#fff;background:var(--pms-primary);border-color:var(--pms-primary)}#substance-matrix-app .pms-progress-marker svg{width:14px;height:14px}#substance-matrix-app .pms-progress-copy{display:inline-flex;min-width:0;align-items:center;gap:6px;line-height:1}#substance-matrix-app .pms-progress-label{min-width:0;font-size:.75rem;font-weight:850;line-height:1.1;overflow-wrap:anywhere}#substance-matrix-app .pms-step-panel h2{color:var(--pms-text);font-size:1.125rem;font-weight:850;line-height:1.2}#substance-matrix-app .pms-step-actions{display:grid;gap:10px}#substance-matrix-app .pms-action-button{display:grid;grid-template-columns:38px 1fr;gap:12px;align-items:center;min-height:56px;cursor:pointer;padding:10px 12px;color:var(--pms-text);background:#ffffff94;border:1px solid rgba(255,255,255,.74);border-radius:16px;font-size:.875rem;font-weight:850;line-height:1.25;text-align:left}#substance-matrix-app .pms-action-button svg{width:38px;height:38px;padding:10px;color:var(--pms-primary);background:var(--pms-primary-soft);border-radius:14px}#substance-matrix-app .pms-action-button.is-primary{color:var(--pms-primary);background:#ffffffd1;border-color:#2d51a038;box-shadow:0 8px 18px #2d51a014}#substance-matrix-app .pms-action-button.is-primary svg{color:#fff;background:var(--pms-primary)}#substance-matrix-app .pms-selection-list{display:flex;flex-wrap:wrap;gap:8px;align-items:center;min-height:36px}#substance-matrix-app .pms-selection-list p{color:#0c2a4894;font-size:.875rem;font-weight:600;line-height:1.35}#substance-matrix-app .pms-selection-slots{display:grid;grid-template-columns:minmax(0,1fr) auto minmax(0,1fr);gap:14px;align-items:stretch}#substance-matrix-app .pms-selection-plus{display:grid;width:28px;place-items:center;color:var(--pms-secondary);font-size:1.25rem;font-weight:900}#substance-matrix-app .pms-selection-slot{position:relative;min-width:0;min-height:104px;border-radius:18px}#substance-matrix-app button.pms-selection-slot{display:grid;grid-template-columns:42px minmax(0,1fr);gap:12px;align-items:center;cursor:pointer;padding:20px;color:#2d51a0b3;background:#ffffff94;border:2px dashed rgba(45,81,160,.32);text-align:left;font-size:.875rem;font-weight:750;line-height:1.2;box-shadow:none}#substance-matrix-app button.pms-selection-slot:hover,#substance-matrix-app button.pms-selection-slot:focus-visible{color:var(--pms-primary);background:#ffffffdb;border-color:#2d51a07a}#substance-matrix-app button.pms-selection-slot.is-disabled{cursor:not-allowed;color:#0c2a4861;background:#ffffff80;border-color:#2d51a024}#substance-matrix-app .pms-selection-placeholder-icon,#substance-matrix-app .pms-selection-empty-icon{display:grid;width:42px;height:42px;place-items:center;color:#2d51a07a;background:#dfe8ff99;border-radius:14px}#substance-matrix-app .pms-selection-placeholder-icon svg{width:20px;height:20px}#substance-matrix-app .pms-selection-placeholder-copy{display:grid;gap:4px}#substance-matrix-app .pms-selection-placeholder-copy strong,#substance-matrix-app .pms-selection-placeholder-copy span{display:block}#substance-matrix-app .pms-selection-placeholder-copy strong{color:#2d51a0c7;font-size:.9375rem;font-weight:850}#substance-matrix-app .pms-selection-placeholder-copy span{color:#0c2a486b;font-size:.8125rem;font-weight:500}#substance-matrix-app .pms-selection-slot.is-filled{min-height:112px;padding:0;background:transparent;border:0;box-shadow:none}#substance-matrix-app .pms-selection-card-tile{width:100%;height:100%;min-height:112px}#substance-matrix-app .pms-selection-card{display:grid;grid-template-columns:38px minmax(0,1fr);gap:9px;align-items:center;min-width:0;cursor:pointer;padding:4px;color:var(--pms-primary);background:transparent;text-align:left}#substance-matrix-app .pms-add-substance,#substance-matrix-app .pms-selection-chip,#substance-matrix-app .pms-picker-head button{display:inline-flex;align-items:center;justify-content:center;cursor:pointer;border-radius:999px;line-height:1}#substance-matrix-app .pms-add-substance{gap:6px;min-height:36px;padding:0 12px;color:#fff;background:var(--pms-primary);font-size:.75rem;font-weight:900}#substance-matrix-app .pms-add-substance svg{width:15px;height:15px}#substance-matrix-app .pms-selection-chip{display:inline-grid;grid-template-columns:30px minmax(0,auto) 18px;gap:8px;min-height:42px;align-items:center;padding:5px 8px 5px 5px;color:var(--pms-text);background:#ffffffc2;border:1px solid color-mix(in srgb,var(--pms-class-strong, var(--pms-accent)) 24%,#fff);border-radius:16px;font-size:.8125rem;font-weight:850}#substance-matrix-app .pms-selection-thumb{display:grid;width:38px;height:38px;min-width:38px;place-items:center;overflow:hidden;background:#ffffff9e;border-radius:11px}#substance-matrix-app .pms-selection-image{display:block;width:30px;height:30px;max-width:30px;max-height:30px;object-fit:contain}#substance-matrix-app .pms-selection-name{min-width:0;overflow-wrap:anywhere;line-height:1.15;color:var(--pms-primary);font-weight:900}#substance-matrix-app .pms-selection-remove{position:absolute;top:10px;right:10px;display:grid;width:24px;height:24px;cursor:pointer;place-items:center;color:#2d51a0a3;background:#dfe8ffb8;border-radius:999px;font-size:1rem;font-weight:700}#substance-matrix-app .pms-single-panel{display:grid;gap:12px;margin-bottom:18px;padding:22px;border-radius:28px}#substance-matrix-app .pms-panel-heading{display:flex;flex-wrap:wrap;align-items:center;gap:14px}#substance-matrix-app .pms-panel-heading>div{min-width:0;flex:1 1 160px}#substance-matrix-app .pms-panel-heading h2{color:var(--pms-text);font-size:1.625rem;font-weight:900;line-height:1.1}#substance-matrix-app .pms-panel-icon{display:grid;width:58px;height:58px;flex:0 0 auto;place-items:center;overflow:hidden;background:#ffffff8f;border-radius:18px}#substance-matrix-app .pms-panel-image{display:block;width:46px;height:46px;object-fit:contain}#substance-matrix-app .pms-single-panel p{color:#0c2a48b8;font-size:.9375rem;font-weight:600;line-height:1.5}#substance-matrix-app .pms-picker-head button{width:32px;height:32px;color:#0c2a48a3;background:#ffffff9e;font-size:1.25rem}#substance-matrix-app .pms-class-substance{--pms-class-accent: var(--pms-class-substance);--pms-class-strong: #2d51a0;--pms-class-tint: rgba(45, 81, 160, .1);--pms-class-label: rgba(45, 81, 160, .62)}#substance-matrix-app .pms-class-medicament{--pms-class-accent: var(--pms-class-medicament);--pms-class-strong: #5f61b8;--pms-class-tint: rgba(95, 97, 184, .12);--pms-class-label: rgba(95, 97, 184, .7)}#substance-matrix-app .pms-slots{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:16px;margin-bottom:20px}#substance-matrix-app .pms-slot{position:relative;display:flex;min-height:144px;flex-direction:column;align-items:center;justify-content:center;gap:10px;padding:20px;border:1px solid var(--pms-border);border-radius:32px;background:var(--pms-glass);box-shadow:var(--pms-shadow);text-align:center;overflow:hidden}#substance-matrix-app .pms-slot.is-empty{color:#0c2a4875;background:#ffffff57;border-color:#ffffff75;box-shadow:none}#substance-matrix-app button.pms-slot{width:100%;cursor:pointer}#substance-matrix-app .pms-slot.is-clickable:hover{border-color:var(--pms-primary);background:#fff}#substance-matrix-app .pms-slot.is-waiting{opacity:1}#substance-matrix-app .pms-slot.is-filled{border-color:var(--pms-class-accent, var(--pms-primary));background:var(--pms-surface)}#substance-matrix-app .pms-slot-icon{display:grid;width:64px;height:64px;place-items:center;color:var(--pms-accent);background:#ffffff6b;border-radius:20px}#substance-matrix-app .pms-slot.is-empty .pms-slot-icon{color:#4c91ff75;background:#ffffff47}#substance-matrix-app .pms-slot.is-filled .pms-slot-icon{color:var(--pms-primary);background:#ffffff94}#substance-matrix-app .pms-slot-icon svg{width:24px;height:24px}#substance-matrix-app .pms-slot-image{display:block;width:100%;height:100%;object-fit:contain}#substance-matrix-app .pms-slot-copy span{display:block;color:#0c2a48c7;font-size:.875rem;font-weight:850;letter-spacing:0}#substance-matrix-app .pms-slot-copy strong{display:block;max-width:128px;margin-top:3px;color:#0c2a487a;font-size:.875rem;font-weight:500;line-height:1.2;overflow-wrap:anywhere}#substance-matrix-app .pms-slot.is-filled .pms-slot-copy strong{color:var(--pms-text);font-weight:900}#substance-matrix-app .pms-instruction{display:inline-flex;gap:10px;align-items:flex-end;margin:-4px 0 14px 4px;padding:0;color:#0c2a48eb;background:transparent;border:0;border-radius:0;font-family:Caveat,Segoe Print,cursive;font-size:1.375rem;font-weight:600;line-height:1.25}#substance-matrix-app .pms-instruction img{display:block;width:44px;height:auto;flex:0 0 auto;filter:brightness(0) saturate(100%) invert(10%) sepia(48%) saturate(1344%) hue-rotate(175deg) brightness(87%) contrast(97%);opacity:.9;transform:translateY(4px)}#substance-matrix-app .pms-instruction span{font-family:inherit;line-height:1}#substance-matrix-app .pms-picker-prompt{justify-content:flex-start;margin:0 0 16px 8px}#substance-matrix-app .pms-picker-prompt img{width:52px;transform:translateY(2px)}#substance-matrix-app .pms-single-generated-hint{display:grid;grid-template-columns:28px minmax(0,1fr) auto;align-items:center;gap:10px;margin:-4px 0 12px;padding:9px 10px;color:#0c2a48b8;background:#ffffffb8;border:1px solid rgba(45,81,160,.16);border-radius:16px;font-size:.8125rem;font-weight:750}#substance-matrix-app .pms-single-generated-icon{display:grid;width:28px;height:28px;place-items:center;color:var(--pms-primary);background:var(--pms-primary-soft);border-radius:999px}#substance-matrix-app .pms-single-generated-icon svg{width:15px;height:15px;stroke-width:2.4}#substance-matrix-app .pms-single-generated-copy{min-width:0;line-height:1.25}#substance-matrix-app .pms-single-generated-hint a{color:var(--pms-primary);font-weight:900;text-decoration:none;white-space:nowrap}#substance-matrix-app .pms-single-generated-hint a:hover,#substance-matrix-app .pms-single-generated-hint a:focus-visible{text-decoration:underline}#substance-matrix-app .pms-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px}#substance-matrix-app .pms-substance{position:relative;display:flex;min-height:112px;cursor:pointer;flex-direction:column;align-items:center;justify-content:center;gap:5px;padding:16px 14px;color:var(--pms-primary);border:1px solid rgba(45,81,160,.1);border-radius:24px;background:#ffffffbd;box-shadow:0 10px 24px #2d51a012;transition:transform .18s ease,background .18s ease,border-color .18s ease,box-shadow .18s ease;overflow:hidden}#substance-matrix-app .pms-substance:before{display:none}#substance-matrix-app .pms-substance:hover,#substance-matrix-app .pms-substance:focus-visible{transform:scale(1.02);border-color:color-mix(in srgb,var(--pms-class-strong, var(--pms-accent)) 38%,#fff);background:#ffffffeb}#substance-matrix-app button:focus-visible,#substance-matrix-app a:focus-visible,#substance-matrix-app [tabindex="-1"]:focus-visible{outline:3px solid var(--pms-text);outline-offset:4px}#substance-matrix-app .pms-substance.is-selected{z-index:1;transform:none;color:var(--pms-primary);border-color:var(--pms-primary);background:linear-gradient(180deg,#e8eefff2,#ffffffd1);box-shadow:0 12px 26px #2d51a01f}#substance-matrix-app .pms-substance.is-selected:before{display:none}#substance-matrix-app .pms-substance.is-disabled{cursor:not-allowed;opacity:.45;border-color:transparent;background:#ffffff40;transform:none}#substance-matrix-app .pms-substance-status{color:#0c2a4873;font-size:.5rem;font-weight:900;letter-spacing:.06em;line-height:1.2;text-align:center;text-transform:uppercase}#substance-matrix-app .pms-check{position:absolute;top:10px;right:10px;display:grid;width:22px;height:22px;place-items:center;color:#fff;background:var(--pms-primary);border-radius:999px;box-shadow:0 8px 18px #0047d838}#substance-matrix-app .pms-check svg{width:12px;height:12px}#substance-matrix-app .pms-substance-icon{display:block;width:56px;height:56px;flex:0 0 auto;color:var(--pms-primary)}#substance-matrix-app .pms-substance-image{display:block;width:100%;height:100%;object-fit:contain}#substance-matrix-app .pms-substance-class{color:var(--pms-class-label, var(--pms-secondary));font-size:.6875rem;font-weight:400;letter-spacing:0;line-height:1;text-transform:none}#substance-matrix-app .pms-substance-name{color:var(--pms-primary);font-size:.9375rem;font-weight:900;line-height:1.15;text-align:center}#substance-matrix-app .pms-result-kicker{margin-bottom:8px;color:#0c2a4880;font-size:.75rem;font-weight:850;line-height:1}#substance-matrix-app .pms-result-header{display:flex;flex-wrap:wrap;align-items:center;justify-content:space-between;gap:16px;margin-bottom:18px}#substance-matrix-app .pms-result-copy{min-width:0;flex:1 1 auto}#substance-matrix-app .pms-result-hero-media{display:inline-flex;align-items:center;gap:8px;flex:0 0 auto}#substance-matrix-app .pms-result-substance-image{display:grid;width:58px;height:58px;place-items:center;overflow:hidden;background:#ffffffa3;border:1px solid color-mix(in srgb,var(--pms-class-strong, var(--pms-primary)) 18%,#fff);border-radius:20px}#substance-matrix-app .pms-result-substance-img{display:block;width:46px;height:46px;object-fit:contain}#substance-matrix-app .pms-result-hero-plus{color:var(--pms-accent);font-size:1.4rem;font-weight:900;line-height:1}#substance-matrix-app .pms-result-header h2{scroll-margin-top:24px;color:var(--pms-text);font-size:clamp(1.35rem,5vw,1.75rem);font-weight:900;letter-spacing:0;line-height:1.12}#substance-matrix-app .pms-result-header h2 span{color:var(--pms-accent)}#substance-matrix-app .pms-result-mark{flex:0 0 auto;color:var(--pms-primary);background:#fff}#substance-matrix-app .pms-result-side{display:flex;flex:1 1 132px;flex-direction:column;align-items:flex-end;gap:12px}#substance-matrix-app .pms-risk-panel,#substance-matrix-app .pms-advice,#substance-matrix-app .pms-note,#substance-matrix-app .pms-disclaimer{border:1px solid var(--pms-border);background:var(--pms-glass);box-shadow:var(--pms-shadow)}#substance-matrix-app .pms-risk-panel{margin-bottom:22px;padding:24px;border-radius:30px;scroll-margin-top:20px}#substance-matrix-app .pms-selection-tray:focus,#substance-matrix-app .pms-risk-panel:focus{outline:none}#substance-matrix-app .pms-risk-topline{display:flex;align-items:center;gap:10px;margin-bottom:14px;color:var(--pms-warning)}#substance-matrix-app .risk-4 .pms-risk-topline{color:var(--pms-critical)}#substance-matrix-app .pms-risk-badge{display:inline-flex;align-items:center;gap:8px;padding:8px 16px;color:#fff;background:var(--pms-warning);border-radius:999px;font-size:.75rem;font-weight:900;letter-spacing:0}#substance-matrix-app .pms-risk-badge svg{width:16px;height:16px;flex:0 0 auto}#substance-matrix-app .risk-4 .pms-risk-badge{background:var(--pms-critical)}#substance-matrix-app .risk-missing .pms-risk-badge{background:var(--pms-primary)}#substance-matrix-app .pms-risk-panel h3{margin-bottom:10px;font-size:1.25rem;font-weight:900;line-height:1.18}#substance-matrix-app .pms-risk-help{margin-bottom:10px;color:var(--pms-text);font-size:.9375rem;font-weight:900;line-height:1.35}#substance-matrix-app .pms-validation-note{display:inline-flex;margin-bottom:12px;padding:7px 10px;color:#0c2a48a8;background:#ffffff8f;border:1px solid var(--pms-border);border-radius:999px;font-size:.6875rem;font-weight:900;letter-spacing:.06em;text-transform:uppercase}#substance-matrix-app .pms-summary,#substance-matrix-app .pms-mechanism{padding:0;color:#0c2a48d1;background:transparent;border:0;border-radius:0;font-weight:700;line-height:1.45}#substance-matrix-app .pms-mechanism{margin-top:14px}#substance-matrix-app .pms-mechanism span,#substance-matrix-app .pms-section h3,#substance-matrix-app .pms-note h3{display:block;margin-bottom:10px;color:#0c2a487a;font-size:.75rem;font-weight:900;letter-spacing:.1em;text-transform:uppercase}#substance-matrix-app .pms-section{margin-bottom:22px}#substance-matrix-app .pms-organ-tags,#substance-matrix-app .pms-list{display:flex;flex-wrap:wrap;gap:12px}#substance-matrix-app .pms-list p,#substance-matrix-app .pms-card{padding:0;color:var(--pms-text);background:transparent;border:0;border-radius:0;font-size:.875rem;font-weight:800;line-height:1.45}#substance-matrix-app .pms-organ-tag{display:inline-flex;min-width:116px;align-items:center;gap:10px;padding:10px 12px;color:var(--pms-text);background:#ffffff94;border:1px solid var(--pms-border);border-radius:18px;font-size:.875rem;font-weight:900;line-height:1.2}#substance-matrix-app .pms-organ-icon{display:grid;width:36px;height:36px;flex:0 0 auto;place-items:center;color:var(--pms-primary);background:var(--pms-primary-soft);border-radius:14px}#substance-matrix-app .pms-organ-icon svg{width:22px;height:22px}#substance-matrix-app .pms-advice,#substance-matrix-app .pms-note,#substance-matrix-app .pms-disclaimer{margin-bottom:22px;padding:22px;border-radius:28px}#substance-matrix-app .pms-advice-title{display:flex;align-items:center;gap:12px;margin-bottom:14px}#substance-matrix-app .pms-advice-title span{display:grid;width:40px;height:40px;place-items:center;color:#fff;background:var(--pms-primary);border-radius:15px;box-shadow:0 10px 22px #0047d829}#substance-matrix-app .pms-advice-title h3{font-size:1.0625rem;font-weight:900;line-height:1.2}#substance-matrix-app .pms-advice ol{display:grid;gap:10px;margin:0;padding:0;list-style:none;counter-reset:advice}#substance-matrix-app .pms-advice li{display:grid;grid-template-columns:30px 1fr;gap:12px;align-items:start;padding:0;color:#0c2a48d1;background:transparent;border:0;border-radius:0;font-size:.875rem;font-weight:800;line-height:1.4}#substance-matrix-app .pms-advice li:before{counter-increment:advice;content:counter(advice);display:grid;width:30px;height:30px;place-items:center;color:#fff;background:var(--pms-primary);border-radius:11px;font-weight:900}#substance-matrix-app .pms-note p,#substance-matrix-app .pms-disclaimer p{color:#0c2a48a3;font-size:.8125rem;font-weight:700;line-height:1.55}#substance-matrix-app .pms-disclaimer div{display:flex;align-items:center;gap:8px;margin-bottom:12px;color:#0c2a488f}#substance-matrix-app .pms-disclaimer span{font-size:.625rem;font-weight:900;letter-spacing:.12em}#substance-matrix-app .pms-actions{display:grid;gap:16px}#substance-matrix-app .pms-primary{width:100%;cursor:pointer;padding:20px;color:#fff;background:var(--pms-primary);border-radius:24px;box-shadow:0 14px 30px #0047d838;font-size:.875rem;font-weight:900;letter-spacing:.08em;text-transform:uppercase}#substance-matrix-app .pms-link{display:inline-flex;align-items:center;justify-content:center;gap:8px;color:#0c2a48a3;font-size:.875rem;font-weight:900;letter-spacing:.08em;text-decoration:none;text-transform:uppercase;cursor:pointer;background:transparent}#substance-matrix-app .pms-link-top{max-width:100%;padding:10px 12px;color:var(--pms-primary);background:#ffffffb8;border:1px solid var(--pms-border);border-radius:16px;box-shadow:var(--pms-shadow);font-size:.75rem;letter-spacing:.04em;line-height:1.15;text-align:center}#substance-matrix-app .pms-toast{position:fixed;z-index:20;right:18px;bottom:18px;max-width:min(360px,calc(100% - 36px));padding:12px 14px;color:var(--pms-text);background:#fffffff0;border:1px solid rgba(0,71,216,.16);border-radius:16px;box-shadow:0 12px 28px #0047d824;font-size:.875rem;font-weight:750;line-height:1.35}#substance-matrix-app .pms-accent{position:absolute;z-index:0;pointer-events:none}#substance-matrix-app .pms-accent-1{width:400px;height:400px;top:-100px;left:-100px;background:radial-gradient(circle,rgba(0,71,216,.15) 0%,transparent 70%);filter:blur(60px)}#substance-matrix-app .pms-accent-2{width:500px;height:500px;right:-100px;bottom:-150px;background:radial-gradient(circle,rgba(242,174,47,.1) 0%,transparent 70%);filter:blur(80px)}#substance-matrix-app .pms-accent-3{width:300px;height:300px;top:40%;right:10%;background:radial-gradient(circle,rgba(76,145,255,.2) 0%,transparent 70%);filter:blur(50px)}@media(max-width:359px){#substance-matrix-app .pms-view{padding:28px 12px 56px}#substance-matrix-app h1{font-size:1.25rem}#substance-matrix-app .pms-header p{font-size:.9375rem}#substance-matrix-app .pms-prevention,#substance-matrix-app .pms-selection-tray,#substance-matrix-app .pms-step-panel,#substance-matrix-app .pms-picker{padding:12px;border-radius:18px}#substance-matrix-app .pms-grid{grid-template-columns:repeat(2,minmax(0,1fr));gap:8px}#substance-matrix-app .pms-substance{min-height:96px;padding:12px 8px}#substance-matrix-app .pms-substance-icon{width:48px;height:48px}#substance-matrix-app .pms-result-header{display:flex;align-items:center;gap:12px;margin-bottom:14px}#substance-matrix-app .pms-result-side{align-items:flex-start}#substance-matrix-app .pms-risk-panel,#substance-matrix-app .pms-advice,#substance-matrix-app .pms-note,#substance-matrix-app .pms-disclaimer{padding:20px;border-radius:28px}}@media(max-width:420px){#substance-matrix-app .pms-version-home{padding-inline:18px}#substance-matrix-app .pms-version-header h1{font-size:1.625rem}#substance-matrix-app .pms-version-grid{grid-template-columns:1fr}}#substance-matrix-app .pms-version-back-global{position:fixed;z-index:20;top:8px;left:8px;width:30px;min-height:30px;margin:0;justify-content:center;padding:0;color:#064ee8;border-color:#064ee838;background:#ffffffeb;box-shadow:0 4px 12px #064ee81f;-webkit-backdrop-filter:blur(8px);backdrop-filter:blur(8px)}#substance-matrix-app .pms-version-back-global svg{width:14px;height:14px}#substance-matrix-app .pms-version-back-global:hover,#substance-matrix-app .pms-version-back-global:focus-visible{color:#fff;border-color:#064ee8;background:#064ee8;outline:none}#substance-matrix-app .pms-version-back-global:focus-visible{outline:3px solid #0039bd;outline-offset:3px}@media(max-width:520px){#substance-matrix-app .pms-version-back-global{top:6px;left:6px;width:28px;min-height:28px;padding:0}}@media(min-width:360px)and (max-width:420px){#substance-matrix-app .pms-view{padding-inline:18px}#substance-matrix-app .pms-header{margin-bottom:22px}#substance-matrix-app .pms-grid{gap:10px}#substance-matrix-app .pms-substance{min-height:104px;padding:12px 8px}#substance-matrix-app .pms-progress{gap:6px}#substance-matrix-app .pms-progress:before,#substance-matrix-app .pms-progress:after{top:12px;left:calc(25% + 14px);right:calc(25% + 14px)}#substance-matrix-app .pms-progress-marker{width:24px;height:24px;font-size:.6875rem}#substance-matrix-app .pms-progress-label{font-size:.6875rem}#substance-matrix-app .pms-risk-panel,#substance-matrix-app .pms-advice,#substance-matrix-app .pms-note,#substance-matrix-app .pms-disclaimer{padding:22px}}@media(min-width:421px){#substance-matrix-app .pms-view{width:min(calc(100% - 40px),560px);padding:52px 0 82px}#substance-matrix-app .pms-grid{grid-template-columns:repeat(3,minmax(0,1fr));gap:12px}}@media(min-width:640px){#substance-matrix-app .pms-view{width:min(calc(100% - 56px),620px);padding:60px 0 92px}#substance-matrix-app h1{font-size:1.75rem}#substance-matrix-app .pms-header{margin-bottom:30px}#substance-matrix-app .pms-header p{max-width:560px}#substance-matrix-app .pms-prevention,#substance-matrix-app .pms-selection-tray,#substance-matrix-app .pms-step-panel,#substance-matrix-app .pms-picker{padding:18px}#substance-matrix-app .pms-step-actions{grid-template-columns:repeat(2,minmax(0,1fr))}#substance-matrix-app .pms-action-button{min-height:70px}#substance-matrix-app .pms-substance{min-height:122px}#substance-matrix-app .pms-risk-panel,#substance-matrix-app .pms-advice,#substance-matrix-app .pms-note,#substance-matrix-app .pms-disclaimer{padding:24px;border-radius:30px}#substance-matrix-app .pms-organ-tags,#substance-matrix-app .pms-list{display:grid;grid-template-columns:repeat(2,minmax(0,1fr))}#substance-matrix-app .pms-organ-tag{width:100%}}@media(min-width:900px){#substance-matrix-app .pms-view{width:min(calc(100% - 80px),640px);padding:72px 0 104px}#substance-matrix-app h1{font-size:2rem}#substance-matrix-app .pms-header p{font-size:1.1875rem}#substance-matrix-app .pms-prevention,#substance-matrix-app .pms-selection-tray,#substance-matrix-app .pms-step-panel,#substance-matrix-app .pms-picker{padding:20px;border-radius:24px}#substance-matrix-app .pms-grid{gap:14px}#substance-matrix-app .pms-substance{min-height:128px}#substance-matrix-app .pms-result-header h2{font-size:clamp(1.65rem,3vw,2rem)}}@media(min-width:1160px){#substance-matrix-app .pms-view{width:min(calc(100% - 96px),660px)}}#substance-matrix-app .pms-picker{padding:0;border:0;border-radius:0;background:transparent;box-shadow:none}#substance-matrix-app .pms-picker .pms-progress{margin-bottom:12px}#substance-matrix-app .pms-picker .pms-grid{padding:0}@media(prefers-reduced-motion:reduce){#substance-matrix-app *,#substance-matrix-app *:before,#substance-matrix-app *:after{transition-duration:.01ms!important;animation-duration:.01ms!important;animation-iteration-count:1!important;scroll-behavior:auto!important}#substance-matrix-app .pms-substance:hover,#substance-matrix-app .pms-substance:focus-visible,#substance-matrix-app .pms-substance.is-selected{transform:none}}#substance-matrix-app .pms-interaction-title button{display:inline;cursor:pointer;margin:0;padding:.03em .08em;color:inherit;background:transparent;border-radius:10px;font:inherit;font-weight:inherit;line-height:inherit;text-align:inherit;transition:color .16s ease,background .16s ease,box-shadow .16s ease,transform .16s ease}#substance-matrix-app .pms-interaction-title button:hover,#substance-matrix-app .pms-interaction-title button:focus-visible{color:var(--pms-text);background:#ffffff94;box-shadow:0 8px 20px #0047d81a,inset 0 0 0 1px #0047d824;transform:translateY(-1px);text-decoration:none}#substance-matrix-app .pms-selection-tray{padding:clamp(22px,4vw,30px)}#substance-matrix-app .pms-picker{margin-bottom:22px}#substance-matrix-app .pms-substance-sheet-header{position:sticky;top:0;z-index:5;margin:-4px -4px 18px;padding:4px 4px 12px;background:color-mix(in srgb,var(--pms-background) 82%,transparent);-webkit-backdrop-filter:blur(14px);backdrop-filter:blur(14px)}#substance-matrix-app .pms-substance-sheet-header .pms-interaction-title{margin-bottom:14px;color:var(--pms-text);font-size:1.75rem;font-weight:900;line-height:1.12}#substance-matrix-app .pms-section-pills{display:flex;gap:8px;overflow-x:auto;padding:2px 0 6px;scrollbar-width:none}#substance-matrix-app .pms-section-pills::-webkit-scrollbar{display:none}#substance-matrix-app .pms-section-pill{flex:0 0 auto;padding:9px 13px;color:#0c2a4899;background:#fffc;border:1px solid rgba(45,81,160,.1);border-radius:999px;font-size:.8125rem;font-weight:850;line-height:1;text-decoration:none}#substance-matrix-app .pms-section-pill.is-active,#substance-matrix-app .pms-section-pill:hover,#substance-matrix-app .pms-section-pill:focus-visible{color:#fff;background:var(--pms-primary);border-color:var(--pms-primary)}#substance-matrix-app .pms-substance-sheet-body{display:grid;gap:20px}#substance-matrix-app .pms-markdown-section{scroll-margin-top:112px}#substance-matrix-app .pms-markdown-section p,#substance-matrix-app .pms-markdown-section li{color:#0c2a48d1;font-size:.9375rem;font-weight:650;line-height:1.58}#substance-matrix-app .pms-markdown-section p+p,#substance-matrix-app .pms-markdown-section p+ul{margin-top:10px}#substance-matrix-app .pms-markdown-section ul{display:grid;gap:8px;margin:12px 0 0;padding-left:20px}#substance-matrix-app .pms-markdown-section li::marker{color:var(--pms-primary)}#substance-matrix-app .pms-sheet-header{position:sticky;top:0;z-index:10;margin:0 0 18px;padding:14px 12px 12px;background:#e9f1ffeb;border:1px solid rgba(255,255,255,.72);border-radius:0 0 24px 24px;box-shadow:0 12px 28px #2d51a01a;-webkit-backdrop-filter:blur(18px);backdrop-filter:blur(18px)}#substance-matrix-app .pms-result-header.pms-sheet-header{align-items:center}#substance-matrix-app .pms-substance-sheet-header.pms-sheet-header{display:grid;gap:10px;margin:0 0 18px;padding:16px 12px 12px}#substance-matrix-app .pms-substance-sheet-header .pms-interaction-title{margin-bottom:0;color:var(--pms-text)}#substance-matrix-app .pms-section-pills{position:sticky;top:88px;z-index:11;margin:0 -4px;padding:4px 4px 8px;background:linear-gradient(180deg,#e9f1fff0,#e9f1ffc2);-webkit-backdrop-filter:blur(14px);backdrop-filter:blur(14px)}#substance-matrix-app .pms-section-pill{color:#0c2a48b8;background:#ffffffe6;border-color:#2d51a029;box-shadow:0 6px 14px #2d51a00f}#substance-matrix-app .pms-sheet-block,#substance-matrix-app .pms-substance-panel .pms-disclaimer{margin-bottom:18px;padding:22px;background:#ffffffb8;border:1px solid rgba(255,255,255,.82);border-radius:26px;box-shadow:0 10px 26px #2d51a014}#substance-matrix-app .pms-markdown-section,#substance-matrix-app .pms-sheet-block{scroll-margin-top:156px}#substance-matrix-app .pms-section h3,#substance-matrix-app .pms-note h3,#substance-matrix-app .pms-markdown-section h3{margin-bottom:12px;color:var(--pms-text);font-size:1.0625rem;font-weight:900;letter-spacing:0;line-height:1.22;text-transform:none}#substance-matrix-app .pms-markdown-section h3:before,#substance-matrix-app .pms-section.pms-sheet-block h3:before{content:"";display:inline-block;width:8px;height:8px;margin-right:9px;vertical-align:.12em;background:var(--pms-primary);border-radius:999px}#substance-matrix-app .pms-result-side .pms-risk-badge{margin-left:auto;white-space:nowrap}#substance-matrix-app .pms-risk-badge.risk-2,#substance-matrix-app .pms-risk-badge.risk-3{background:var(--pms-warning)}#substance-matrix-app .pms-risk-badge.risk-3{gap:10px;padding:11px 18px;font-size:.875rem;box-shadow:0 10px 22px #f2ae2f2e}#substance-matrix-app .pms-risk-badge.risk-3 svg{width:21px;height:21px;stroke-width:2.6}#substance-matrix-app .pms-risk-panel{background:#ffffffc7;border-color:#ffffffdb}#substance-matrix-app .pms-risk-panel.risk-3{border-color:#f2ae2f57;background:linear-gradient(180deg,#ffffffd6,#fff6e1b8)}@media(max-width:420px){#substance-matrix-app .pms-sheet-header{border-radius:0 0 20px 20px;padding-inline:10px}#substance-matrix-app .pms-result-side{align-items:flex-start;flex-basis:100%}#substance-matrix-app .pms-result-side .pms-risk-badge{margin-left:0}#substance-matrix-app .pms-sheet-block,#substance-matrix-app .pms-substance-panel .pms-disclaimer{padding:18px;border-radius:22px}}#substance-matrix-app .pms-selection-plus{width:42px;color:var(--pms-primary);font-size:2.25rem;font-weight:950;line-height:1}#substance-matrix-app button.pms-selection-slot.is-empty{grid-template-columns:minmax(0,1fr);justify-items:center;text-align:center}#substance-matrix-app .pms-selection-slot{width:94%;height:124px;min-height:124px;justify-self:center}#substance-matrix-app button.pms-selection-slot,#substance-matrix-app .pms-selection-slot.is-filled,#substance-matrix-app .pms-selection-card-tile{height:124px;min-height:124px;box-sizing:border-box}#substance-matrix-app .pms-selection-remove{display:flex;align-items:center;justify-content:center;line-height:1;padding:0;transition:background .16s ease,color .16s ease,transform .16s ease}#substance-matrix-app .pms-selection-remove:hover,#substance-matrix-app .pms-selection-remove:focus-visible{color:var(--pms-primary);background:#ffffffe6;transform:translateY(-1px)}#substance-matrix-app .pms-selection-remove svg{width:14px;height:14px;stroke-width:2.6}#substance-matrix-app .pms-markdown-section h3:before,#substance-matrix-app .pms-section.pms-sheet-block h3:before{display:none;content:none}#substance-matrix-app .pms-sheet-header{margin:0 0 20px;padding:12px 0 14px;background:linear-gradient(180deg,#e9f1fffa,#e9f1ffdb);border:0;border-bottom:1px solid rgba(45,81,160,.1);border-radius:0;box-shadow:0 10px 22px #2d51a00f}#substance-matrix-app .pms-result-header.pms-sheet-header,#substance-matrix-app .pms-substance-sheet-header.pms-sheet-header{padding-inline:2px}#substance-matrix-app .pms-result-header h2,#substance-matrix-app .pms-substance-sheet-header .pms-interaction-title{font-weight:760}#substance-matrix-app .pms-section-pill{font-weight:620}#substance-matrix-app .pms-section h3,#substance-matrix-app .pms-note h3,#substance-matrix-app .pms-markdown-section h3,#substance-matrix-app .pms-advice-title h3{font-weight:720}#substance-matrix-app .pms-markdown-section p,#substance-matrix-app .pms-markdown-section li,#substance-matrix-app .pms-summary,#substance-matrix-app .pms-card,#substance-matrix-app .pms-list p,#substance-matrix-app .pms-advice li{font-weight:520}#substance-matrix-app .pms-risk-help,#substance-matrix-app .pms-risk-badge,#substance-matrix-app .pms-organ-tag{font-weight:680}#substance-matrix-app .pms-section-pills{top:78px;background:linear-gradient(180deg,#e9f1fff5,#e9f1ffb3)}#substance-matrix-app .pms-result-header .pms-section-pills{flex:0 0 100%;width:100%}#substance-matrix-app .pms-advice-list{display:grid;gap:10px;margin:0;padding-left:20px}#substance-matrix-app .pms-advice-list li{color:#0c2a48d1;font-size:.9375rem;font-weight:520;line-height:1.5}#substance-matrix-app .pms-advice-list li::marker{color:var(--pms-primary);font-weight:700}#substance-matrix-app .pms-interaction-panel .pms-sheet-header{margin-bottom:12px}#substance-matrix-app .pms-interaction-panel .pms-substance-sheet-body{gap:12px}#substance-matrix-app .pms-interaction-panel .pms-sheet-block,#substance-matrix-app .pms-interaction-panel .pms-risk-panel,#substance-matrix-app .pms-interaction-panel .pms-note,#substance-matrix-app .pms-interaction-panel .pms-disclaimer{margin-bottom:12px}#substance-matrix-app .pms-interaction-panel .pms-section-pills{padding-bottom:4px}#substance-matrix-app .pms-sheet-header{background:#ffffffe6;border:1px solid rgba(45,81,160,.14);border-top:0;border-radius:0 0 22px 22px;box-shadow:0 14px 30px #0c2a481f}#substance-matrix-app .pms-sheet-header:after{content:"";position:absolute;left:12px;right:12px;bottom:-1px;height:1px;background:#2d51a02e}#substance-matrix-app .pms-sheet-header{background:#fffffff5;border:1px solid rgba(45,81,160,.12);border-top:0;border-radius:0 0 16px 16px;box-shadow:none;-webkit-backdrop-filter:blur(12px);backdrop-filter:blur(12px)}#substance-matrix-app .pms-sheet-header:after{left:0;right:0;bottom:-1px;height:1px;background:#2d51a029}#substance-matrix-app .pms-result-header.pms-sheet-header,#substance-matrix-app .pms-substance-sheet-header.pms-sheet-header{padding:12px 12px 10px}#substance-matrix-app .pms-sheet-header .pms-interaction-title{color:#102f4d}#substance-matrix-app .pms-section-pills{background:transparent;-webkit-backdrop-filter:none;backdrop-filter:none;padding-top:6px}#substance-matrix-app .pms-section-pill{color:#0c2a48ad;background:#fff;border:1px solid rgba(45,81,160,.14);box-shadow:none}#substance-matrix-app .pms-section-pill.is-active,#substance-matrix-app .pms-section-pill:hover,#substance-matrix-app .pms-section-pill:focus-visible{color:#fff;background:var(--pms-primary);border-color:var(--pms-primary);box-shadow:none}#substance-matrix-app .pms-result-side .pms-risk-badge{box-shadow:none}#substance-matrix-app .pms-interaction-panel .pms-substance-sheet-body{gap:8px}#substance-matrix-app .pms-interaction-panel .pms-sheet-block,#substance-matrix-app .pms-interaction-panel .pms-risk-panel,#substance-matrix-app .pms-interaction-panel .pms-note,#substance-matrix-app .pms-interaction-panel .pms-disclaimer,#substance-matrix-app .pms-interaction-panel .pms-sheet-header{margin-bottom:8px}#substance-matrix-app .pms-sheet-header{border-radius:22px;border-top:1px solid rgba(45,81,160,.12);overflow:hidden}#substance-matrix-app .pms-sheet-header:after{left:16px;right:16px}#substance-matrix-app .pms-result-header.pms-sheet-header{display:grid;grid-template-columns:minmax(0,1fr) auto;align-items:center;gap:10px 12px;padding:14px 14px 12px}#substance-matrix-app .pms-result-header .pms-result-copy{min-width:0}#substance-matrix-app .pms-result-header .pms-interaction-title{display:flex;min-width:0;flex-wrap:wrap;align-items:center;gap:3px 6px;margin:0;font-size:clamp(1.25rem,4.8vw,1.62rem);line-height:1.08}#substance-matrix-app .pms-result-header .pms-interaction-title span{flex:0 0 auto;font-size:.82em}#substance-matrix-app .pms-result-header .pms-result-side{display:flex;min-width:max-content;flex:0 0 auto;align-items:center;justify-content:flex-end}#substance-matrix-app .pms-risk-badge,#substance-matrix-app .pms-result-side .pms-risk-badge,#substance-matrix-app .pms-risk-badge.risk-3{display:inline-flex;min-height:36px;align-items:center;justify-content:center;gap:8px;padding:9px 14px;border-radius:999px;box-shadow:0 8px 18px #0c2a481f;font-size:.8125rem;font-weight:850;line-height:1;white-space:nowrap}#substance-matrix-app .pms-risk-badge svg,#substance-matrix-app .pms-risk-badge.risk-3 svg{width:18px;height:18px;flex:0 0 auto;stroke-width:2.5}#substance-matrix-app .pms-risk-badge.risk-1{background:var(--pms-primary)}#substance-matrix-app .pms-risk-badge.risk-2{background:#d89418}#substance-matrix-app .pms-risk-badge.risk-3{background:var(--pms-warning)}#substance-matrix-app .pms-risk-badge.risk-4{background:var(--pms-critical)}#substance-matrix-app .pms-result-header .pms-section-pills{grid-column:1 / -1;width:100%;margin-top:2px;padding:4px 0 2px;gap:7px}#substance-matrix-app .pms-result-header .pms-section-pill{min-height:32px;display:inline-flex;align-items:center;padding:8px 12px;font-size:.8rem}@media(max-width:420px){#substance-matrix-app .pms-result-header.pms-sheet-header{grid-template-columns:1fr;align-items:start;padding:12px 12px 10px}#substance-matrix-app .pms-result-header .pms-result-side{min-width:0;justify-content:flex-start}#substance-matrix-app .pms-result-header .pms-risk-badge{min-height:34px}}#substance-matrix-app .pms-shell{background:radial-gradient(circle at 16% 12%,rgba(0,214,144,.16),transparent 28%),radial-gradient(circle at 88% 18%,rgba(144,0,214,.14),transparent 26%),radial-gradient(circle at 78% 82%,rgba(214,0,70,.12),transparent 30%),var(--pms-background)}#substance-matrix-app .pms-bg-doodle-zap-1,#substance-matrix-app .pms-bg-doodle-zap-4,#substance-matrix-app .pms-bg-doodle-sparkle-7{background:#0047d838;color:#fff}#substance-matrix-app .pms-bg-doodle-sparkle-1,#substance-matrix-app .pms-bg-doodle-zap-5,#substance-matrix-app .pms-bg-doodle-sparkle-8{background:#00d6903d;color:#fff}#substance-matrix-app .pms-bg-doodle-zap-2,#substance-matrix-app .pms-bg-doodle-sparkle-3,#substance-matrix-app .pms-bg-doodle-zap-6{background:#9000d633;color:#fff}#substance-matrix-app .pms-bg-doodle-sparkle-2,#substance-matrix-app .pms-bg-doodle-sparkle-5,#substance-matrix-app .pms-bg-doodle-zap-7,#substance-matrix-app .pms-bg-doodle-sparkle-9{background:#d600462e;color:#fff}#substance-matrix-app .pms-brand-mark,#substance-matrix-app .pms-result-mark,#substance-matrix-app .pms-add-substance,#substance-matrix-app .pms-primary{background:var(--pms-primary);box-shadow:0 10px 24px #0047d857}#substance-matrix-app .pms-prevention-icon,#substance-matrix-app .pms-panel-icon,#substance-matrix-app .pms-selection-placeholder-icon,#substance-matrix-app .pms-selection-empty-icon,#substance-matrix-app .pms-single-generated-icon{color:var(--pms-primary);background:#0047d81c}#substance-matrix-app .pms-substance:hover,#substance-matrix-app .pms-substance:focus-visible{border-color:color-mix(in srgb,var(--pms-class-strong, var(--pms-funky-green)) 42%,#fff);box-shadow:0 12px 28px #0047d81f}#substance-matrix-app .pms-substance.is-selected,#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile{border-color:var(--pms-primary);background:linear-gradient(180deg,#dbe8fff5,#ffffffdb);box-shadow:0 14px 30px #0047d829}#substance-matrix-app .pms-section-pill{border-color:#0047d824;color:#0c2a48b8}#substance-matrix-app .pms-section-pill:nth-child(3n+1):hover,#substance-matrix-app .pms-section-pill:nth-child(3n+1):focus-visible{background:var(--pms-funky-green);border-color:var(--pms-funky-green);color:#05301f}#substance-matrix-app .pms-section-pill:nth-child(3n+2):hover,#substance-matrix-app .pms-section-pill:nth-child(3n+2):focus-visible{background:var(--pms-funky-violet);border-color:var(--pms-funky-violet);color:#fff}#substance-matrix-app .pms-section-pill:nth-child(3n):hover,#substance-matrix-app .pms-section-pill:nth-child(3n):focus-visible{background:var(--pms-funky-pink);border-color:var(--pms-funky-pink);color:#fff}#substance-matrix-app .pms-section-pill.is-active{color:#fff;background:var(--pms-primary);border-color:var(--pms-primary);box-shadow:0 8px 18px #0047d829}#substance-matrix-app .pms-risk-badge.risk-1{background:var(--pms-funky-green);color:#05301f}#substance-matrix-app .pms-risk-badge.risk-2{background:var(--pms-funky-violet);color:#fff}#substance-matrix-app .pms-risk-badge.risk-3{background:var(--pms-warning);color:#2d2100}#substance-matrix-app .pms-risk-badge.risk-4{background:var(--pms-critical);color:#fff}#substance-matrix-app .pms-risk-panel.risk-3{border-color:#f4a9005c;background:linear-gradient(180deg,#ffffffe0,#fff0bfb8)}#substance-matrix-app .pms-risk-panel.risk-4{border-color:#d6004647;background:linear-gradient(180deg,#ffffffe0,#ffe0ebbd)}#substance-matrix-app .pms-selection-tray{background:#ffffffb8;box-shadow:0 26px 54px #0047d829,0 10px 22px #9000d614,inset 0 1px #ffffffeb}#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile,#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile.pms-substance,#substance-matrix-app .pms-selection-card-tile.pms-substance.is-selected{background:#fff;border-color:var(--pms-primary);box-shadow:0 18px 34px #0047d857,0 6px 14px #00d6901a}#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile:hover,#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile:focus-visible{background:#fff;box-shadow:0 22px 40px #0047d838,0 8px 18px #9000d61a}#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile:after{content:"";position:absolute;inset:auto 18px 10px;height:18px;background:linear-gradient(90deg,#0047d857,#00d69029,#d600461f);border-radius:999px;filter:blur(14px);opacity:.95;pointer-events:none}#substance-matrix-app .pms-bg-doodle{background:transparent;border-radius:0;color:#0047d857;filter:drop-shadow(0 10px 18px rgba(0,71,216,.18));mix-blend-mode:multiply}#substance-matrix-app .pms-bg-doodle svg{width:100%;height:100%;stroke-width:2.35}#substance-matrix-app .pms-bg-doodle-zap-1,#substance-matrix-app .pms-bg-doodle-zap-4,#substance-matrix-app .pms-bg-doodle-sparkle-7{color:#0047d857}#substance-matrix-app .pms-bg-doodle-sparkle-1,#substance-matrix-app .pms-bg-doodle-zap-5,#substance-matrix-app .pms-bg-doodle-sparkle-8{color:#00d69057}#substance-matrix-app .pms-bg-doodle-zap-2,#substance-matrix-app .pms-bg-doodle-sparkle-3,#substance-matrix-app .pms-bg-doodle-zap-6{color:#9000d64d}#substance-matrix-app .pms-bg-doodle-sparkle-2,#substance-matrix-app .pms-bg-doodle-sparkle-5,#substance-matrix-app .pms-bg-doodle-zap-7,#substance-matrix-app .pms-bg-doodle-sparkle-9{color:#d6004647}#substance-matrix-app .pms-shell{background:radial-gradient(circle at 14% 10%,rgba(0,214,144,.34),transparent 32%),radial-gradient(circle at 90% 16%,rgba(144,0,214,.15),transparent 30%),radial-gradient(circle at 78% 84%,rgba(214,0,70,.12),transparent 34%),linear-gradient(135deg,#00d6901a,#0047d81f 48%,#9000d61a),var(--pms-background)}#substance-matrix-app .pms-picker-prompt-second{margin:4px 0 12px 12px;align-items:center}#substance-matrix-app .pms-picker-prompt-second img{width:48px;transform:translateY(8px) rotate(-8deg)}#substance-matrix-app .pms-picker-prompt-second+.pms-grid{margin-top:2px}#substance-matrix-app .pms-single-generated-hint+.pms-picker-prompt-second{margin-top:4px}#substance-matrix-app .pms-shell{background:radial-gradient(circle at 12% 12%,rgba(0,214,144,.12),transparent 34%),radial-gradient(circle at 88% 14%,rgba(144,0,214,.09),transparent 32%),radial-gradient(circle at 80% 82%,rgba(214,0,70,.06),transparent 34%),linear-gradient(135deg,#00d69012,#0047d83d 52%,#9000d614),#e8f2ff;background-attachment:fixed}#substance-matrix-app .pms-result-side .pms-risk-badge.risk-3,#substance-matrix-app .pms-risk-badge.risk-3{color:#3b2b00;background:#f2b84b;border:1px solid #f2b84b;box-shadow:0 8px 18px #0c2a481a}#substance-matrix-app .pms-result-side .pms-risk-badge.risk-3 svg,#substance-matrix-app .pms-risk-badge.risk-3 svg{color:#3b2b00}#substance-matrix-app .pms-risk-panel.risk-3{border-color:#f0c978;background:#fff8e8;box-shadow:0 10px 24px #0c2a4814}#substance-matrix-app .pms-new-search-panel{display:flex;align-items:center;justify-content:space-between;gap:14px;margin-top:18px;padding:18px;border-color:#ffffffb8;background:#ffffffb8;box-shadow:0 18px 38px #0047d81f}#substance-matrix-app .pms-new-search-panel h3{margin:0 0 4px;font-size:1rem;font-weight:900}#substance-matrix-app .pms-new-search-panel p{margin:0;color:#0c2a48ad;font-size:.875rem;font-weight:700}#substance-matrix-app .pms-new-search-button{display:inline-flex;min-height:42px;flex:0 0 auto;align-items:center;justify-content:center;gap:8px;padding:10px 14px;color:#fff;background:var(--pms-primary);border:1px solid rgba(255,255,255,.5);border-radius:999px;box-shadow:0 12px 24px #0047d833;font-size:.875rem;font-weight:900;line-height:1;white-space:nowrap}#substance-matrix-app .pms-new-search-button svg{width:17px;height:17px;stroke-width:2.6}#substance-matrix-app .pms-new-search-button:hover,#substance-matrix-app .pms-new-search-button:focus-visible{background:color-mix(in srgb,var(--pms-primary) 88%,var(--pms-funky-violet));box-shadow:0 16px 30px #0047d842;transform:translateY(-1px)}@media(max-width:520px){#substance-matrix-app .pms-new-search-panel{align-items:stretch;flex-direction:column}#substance-matrix-app .pms-new-search-button{width:100%}}#substance-matrix-app .pms-new-search-panel{justify-content:center;padding:14px;background:transparent;border-color:transparent;box-shadow:none}#substance-matrix-app .pms-new-search-button{min-height:42px;min-width:190px;padding:10px 20px;color:var(--pms-primary);background:#fff;border:1px solid rgba(0,71,216,.18);box-shadow:0 8px 18px #0047d814;text-align:center}#substance-matrix-app .pms-new-search-button:hover,#substance-matrix-app .pms-new-search-button:focus-visible{color:#fff;background:var(--pms-primary);border-color:var(--pms-primary);box-shadow:0 10px 22px #0047d824;transform:none}#substance-matrix-app .pms-section-pill:nth-child(3n+1):hover,#substance-matrix-app .pms-section-pill:nth-child(3n+1):focus-visible,#substance-matrix-app .pms-section-pill:nth-child(3n+2):hover,#substance-matrix-app .pms-section-pill:nth-child(3n+2):focus-visible,#substance-matrix-app .pms-section-pill:nth-child(3n):hover,#substance-matrix-app .pms-section-pill:nth-child(3n):focus-visible,#substance-matrix-app .pms-section-pill:hover,#substance-matrix-app .pms-section-pill:focus-visible{color:var(--pms-primary);background:#eef5ff;border-color:#0047d842;box-shadow:0 6px 14px #0047d814}#substance-matrix-app .pms-section-pill.is-active,#substance-matrix-app .pms-section-pill.is-active:hover,#substance-matrix-app .pms-section-pill.is-active:focus-visible{color:#fff;background:var(--pms-primary);border-color:var(--pms-primary);box-shadow:0 8px 18px #0047d829}#substance-matrix-app .pms-new-search-panel{padding:0;background:transparent;border:0;box-shadow:none}#substance-matrix-app .pms-new-search-button{width:100%;min-height:54px;min-width:0;color:#fff;background:var(--pms-primary);border:1px solid var(--pms-primary);border-radius:24px;box-shadow:0 12px 24px #0047d829}#substance-matrix-app .pms-new-search-button:hover,#substance-matrix-app .pms-new-search-button:focus-visible{color:#fff;background:#003fc0;border-color:#003fc0;box-shadow:0 14px 28px #0047d833;transform:none}#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile,#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile.pms-substance,#substance-matrix-app .pms-selection-card-tile.pms-substance.is-selected,#substance-matrix-app .pms-substance.is-selected,#substance-matrix-app .pms-substance.pms-selection-card-tile.is-selected{background:#fff;border-color:var(--pms-primary);box-shadow:0 10px 22px #0047d81f}#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile:hover,#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile:focus-visible{background:#fff;box-shadow:0 12px 24px #0047d824}#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile:before,#substance-matrix-app .pms-selection-slot.is-filled .pms-selection-card-tile:after,#substance-matrix-app .pms-substance.pms-selection-card-tile.is-selected:before,#substance-matrix-app .pms-substance.pms-selection-card-tile.is-selected:after{content:none;display:none}#substance-matrix-app .pms-bg-doodle{opacity:.58}#substance-matrix-app .pms-bg-doodle-zap-1{top:9vh;left:6vw;right:auto}#substance-matrix-app .pms-bg-doodle-sparkle-1{top:11vh;left:74vw;right:auto}#substance-matrix-app .pms-bg-doodle-zap-2{top:24vh;left:88vw;right:auto}#substance-matrix-app .pms-bg-doodle-sparkle-2{top:30vh;left:9vw;right:auto}#substance-matrix-app .pms-bg-doodle-sparkle-3{top:39vh;left:79vw;right:auto}#substance-matrix-app .pms-bg-doodle-zap-3{top:51vh;left:12vw;right:auto}#substance-matrix-app .pms-bg-doodle-sparkle-4{top:60vh;left:91vw;right:auto}#substance-matrix-app .pms-bg-doodle-zap-4{top:68vh;left:7vw;right:auto}#substance-matrix-app .pms-bg-doodle-sparkle-5{top:75vh;left:82vw;right:auto}#substance-matrix-app .pms-bg-doodle-zap-5{top:87vh;left:5vw;right:auto}#substance-matrix-app .pms-bg-doodle-sparkle-6{top:89vh;left:63vw;right:auto}#substance-matrix-app .pms-bg-doodle-sparkle-7{top:17vh;left:22vw;right:auto;opacity:.42}#substance-matrix-app .pms-bg-doodle-zap-6{top:34vh;left:69vw;right:auto;opacity:.42}#substance-matrix-app .pms-bg-doodle-sparkle-8{top:72vh;left:29vw;right:auto;opacity:.42}#substance-matrix-app .pms-bg-doodle-zap-7{top:5vh;left:55vw;right:auto;opacity:.36}#substance-matrix-app .pms-bg-doodle-sparkle-9{top:95vh;left:43vw;right:auto;opacity:.36}@media(max-width:720px){#substance-matrix-app .pms-bg-doodle{opacity:.5}#substance-matrix-app .pms-bg-doodle-zap-1{left:5vw}#substance-matrix-app .pms-bg-doodle-sparkle-1{left:78vw}#substance-matrix-app .pms-bg-doodle-zap-2{left:90vw}#substance-matrix-app .pms-bg-doodle-sparkle-2{left:8vw}#substance-matrix-app .pms-bg-doodle-sparkle-3{left:84vw}#substance-matrix-app .pms-bg-doodle-zap-3{left:10vw}#substance-matrix-app .pms-bg-doodle-sparkle-4{left:88vw}#substance-matrix-app .pms-bg-doodle-zap-4{left:6vw}#substance-matrix-app .pms-bg-doodle-sparkle-5{left:80vw}#substance-matrix-app .pms-bg-doodle-zap-5{left:7vw}#substance-matrix-app .pms-bg-doodle-sparkle-6{left:72vw}#substance-matrix-app .pms-bg-doodle-sparkle-7{left:25vw;opacity:.28}#substance-matrix-app .pms-bg-doodle-zap-6{left:68vw;opacity:.28}#substance-matrix-app .pms-bg-doodle-sparkle-8{left:24vw;opacity:.28}#substance-matrix-app .pms-bg-doodle-zap-7{left:58vw;opacity:.24}#substance-matrix-app .pms-bg-doodle-sparkle-9{left:45vw;opacity:.24}}#substance-matrix-app .pms-interaction-panel .pms-result-header.pms-sheet-header,#substance-matrix-app .pms-interaction-panel .pms-sheet-block,#substance-matrix-app .pms-interaction-panel .pms-note,#substance-matrix-app .pms-interaction-panel .pms-disclaimer{background:#f7fbff;border-color:#0047d81f;box-shadow:0 10px 24px #0047d814}#substance-matrix-app .pms-interaction-panel .pms-result-header.pms-sheet-header{background:#fff}#substance-matrix-app .pms-interaction-panel .pms-risk-panel.risk-3{position:relative;overflow:hidden;background:#f7fbff;border-color:#0047d81f;box-shadow:0 10px 24px #0047d814}#substance-matrix-app .pms-interaction-panel .pms-risk-panel.risk-3:before{content:"";position:absolute;inset:0 auto 0 0;width:6px;background:#f2b84b;border-radius:26px 0 0 26px}#substance-matrix-app .pms-interaction-panel .pms-risk-badge.risk-3{color:#3b2b00;background:#f2b84b;border-color:#f2b84b;box-shadow:none}#substance-matrix-app .pms-interaction-panel .pms-new-search-panel{padding:0;background:transparent;border:0;box-shadow:none}#substance-matrix-app .pms-interaction-panel .pms-new-search-button{width:100%;color:var(--pms-primary);background:#f7fbff;border:1px solid rgba(0,71,216,.18);box-shadow:0 8px 18px #0047d814}#substance-matrix-app .pms-interaction-panel .pms-new-search-button:hover,#substance-matrix-app .pms-interaction-panel .pms-new-search-button:focus-visible{color:#fff;background:var(--pms-primary);border-color:var(--pms-primary);box-shadow:0 10px 22px #0047d824}#substance-matrix-app .pms-result-header.pms-sheet-header{grid-template-columns:minmax(0,1fr);gap:12px}#substance-matrix-app .pms-result-header .pms-result-intro{display:grid;gap:3px}#substance-matrix-app .pms-result-header .pms-result-eyebrow{color:var(--pms-primary);font-size:.75rem;font-weight:800;line-height:1.2;text-transform:uppercase}#substance-matrix-app .pms-result-header .pms-result-intro p{margin:0;color:var(--pms-text-muted);font-size:.82rem;font-weight:500;line-height:1.4}#substance-matrix-app .pms-result-header .pms-result-equation{display:grid;grid-template-columns:minmax(0,1fr) 30px auto;align-items:center;gap:12px;min-width:0;padding:12px 14px;background:#f5f9ff;border:1px solid rgba(0,71,216,.12);border-radius:12px}#substance-matrix-app .pms-result-header .pms-interaction-title{min-width:0;margin:0}#substance-matrix-app .pms-result-header .pms-equation-sign{color:var(--pms-primary);font-size:1.35rem;font-weight:900;line-height:1}#substance-matrix-app .pms-result-header .pms-result-side{justify-self:end}@media(max-width:620px){#substance-matrix-app .pms-result-header .pms-result-equation{grid-template-columns:minmax(0,1fr);justify-items:start}#substance-matrix-app .pms-result-header .pms-result-side{justify-self:start}}#substance-matrix-app .pms-risk-theme-1{--pms-current-risk: #00b879;--pms-current-risk-soft: #e4f8f0;--pms-current-risk-ink: #08734f}#substance-matrix-app .pms-risk-theme-2{--pms-current-risk: #e6b31e;--pms-current-risk-soft: #fff5d6;--pms-current-risk-ink: #8a6500}#substance-matrix-app .pms-risk-theme-3{--pms-current-risk: #ff8a00;--pms-current-risk-soft: #fff0dc;--pms-current-risk-ink: #a65300}#substance-matrix-app .pms-risk-theme-4{--pms-current-risk: #d60046;--pms-current-risk-soft: #ffe5ed;--pms-current-risk-ink: #b0003a}#substance-matrix-app .pms-shell.pms-risk-theme-1{background:radial-gradient(circle at 12% 12%,rgba(0,184,121,.18),transparent 34%),linear-gradient(135deg,#e4f8f0,#e2edff 58%,#eaf0ff)}#substance-matrix-app .pms-shell.pms-risk-theme-2{background:radial-gradient(circle at 12% 12%,rgba(230,179,30,.17),transparent 34%),linear-gradient(135deg,#fff5d6,#e8efff 58%,#eef1ff)}#substance-matrix-app .pms-shell.pms-risk-theme-3{background:radial-gradient(circle at 12% 12%,rgba(240,154,50,.2),transparent 34%),linear-gradient(135deg,#ffead2,#e6edff 58%,#eeeaff)}#substance-matrix-app .pms-shell.pms-risk-theme-4{background:radial-gradient(circle at 12% 12%,rgba(214,0,70,.16),transparent 34%),linear-gradient(135deg,#ffe3eb,#e9eaff 58%,#f0e8f7)}#substance-matrix-app .pms-interaction-panel[class*=pms-risk-theme-] .pms-result-equation{background:#f7fbff;border-color:color-mix(in srgb,var(--pms-current-risk) 28%,white)}#substance-matrix-app .pms-interaction-panel[class*=pms-risk-theme-] .pms-risk-badge{color:var(--pms-current-risk-ink);background:#fff;border:0;box-shadow:none}#substance-matrix-app .pms-interaction-panel[class*=pms-risk-theme-] .pms-risk-badge svg{color:currentColor}#substance-matrix-app .pms-interaction-panel[class*=pms-risk-theme-] .pms-risk-panel{position:relative;overflow:hidden;background:#f7fbff;border-color:#0047d81f}#substance-matrix-app .pms-interaction-panel[class*=pms-risk-theme-] .pms-risk-panel:before{content:"";position:absolute;inset:0 auto 0 0;width:6px;background:var(--pms-current-risk);border-radius:26px 0 0 26px}#substance-matrix-app .pms-single-generated-hint{grid-template-columns:30px minmax(0,1fr) 26px;gap:12px;min-height:48px;padding:10px 12px;color:var(--pms-primary);background:#fff;border:1px solid rgba(0,71,216,.2);border-radius:18px;box-shadow:0 10px 22px #0047d814;text-decoration:none}#substance-matrix-app .pms-single-generated-hint:hover,#substance-matrix-app .pms-single-generated-hint:focus-visible{border-color:#0047d861;box-shadow:0 12px 26px #0047d81f;transform:translateY(-1px)}#substance-matrix-app .pms-single-generated-copy{color:var(--pms-primary);font-size:.875rem;font-weight:850}#substance-matrix-app .pms-single-generated-action{display:grid;width:26px;height:26px;place-items:center;color:#fff;background:var(--pms-primary);border-radius:999px}#substance-matrix-app .pms-single-generated-action svg{width:14px;height:14px;stroke-width:2.5}#substance-matrix-app .pms-step-choose_second .pms-view{padding-top:36px}#substance-matrix-app .pms-step-choose_second .pms-header{margin-bottom:16px}#substance-matrix-app .pms-step-choose_second .pms-brand{margin-bottom:12px}#substance-matrix-app .pms-step-choose_second .pms-header p{font-size:1rem;line-height:1.28}#substance-matrix-app .pms-step-choose_second .pms-selection-tray{gap:14px;margin-bottom:14px;padding:18px}#substance-matrix-app .pms-step-choose_second .pms-selection-slot,#substance-matrix-app .pms-step-choose_second .pms-selection-card-tile{min-height:96px}#substance-matrix-app .pms-picker.is-choosing-second{gap:8px;margin-bottom:14px}#substance-matrix-app .pms-picker.is-choosing-second .pms-single-generated-hint{margin:-2px 0 4px}#substance-matrix-app .pms-picker.is-choosing-second .pms-picker-prompt-second{margin:0 0 8px 12px}#substance-matrix-app .pms-picker.is-choosing-second .pms-picker-prompt-second img{width:38px;transform:translateY(5px) rotate(-8deg)}#substance-matrix-app .pms-picker.is-choosing-second .pms-grid{gap:10px}#substance-matrix-app .pms-picker.is-choosing-second .pms-substance{min-height:104px;padding:12px 10px}#substance-matrix-app .pms-picker.is-choosing-second .pms-substance-icon{width:48px;height:48px}#substance-matrix-app .pms-picker.is-choosing-second .pms-substance-name{font-size:.875rem}@media(min-width:560px){#substance-matrix-app .pms-picker.is-choosing-second .pms-grid{grid-template-columns:repeat(4,minmax(0,1fr))}}#substance-matrix-app .pms-view-matrix{padding-top:36px}#substance-matrix-app .pms-view-matrix .pms-header{margin-bottom:16px}#substance-matrix-app .pms-view-matrix .pms-brand{margin-bottom:12px}#substance-matrix-app .pms-view-matrix .pms-header p{font-size:1rem;line-height:1.28}#substance-matrix-app .pms-view-matrix .pms-selection-tray{gap:14px;margin-bottom:14px;padding:18px}#substance-matrix-app .pms-view-matrix .pms-selection-slot,#substance-matrix-app .pms-view-matrix .pms-selection-card-tile{min-height:96px}#substance-matrix-app .pms-view-matrix .pms-picker{gap:8px;margin-bottom:14px}#substance-matrix-app .pms-view-matrix .pms-picker-prompt{margin:0 0 8px 12px}#substance-matrix-app .pms-view-matrix .pms-picker-prompt img{width:38px;transform:translateY(5px) rotate(-8deg)}#substance-matrix-app .pms-view-matrix .pms-grid{gap:10px}#substance-matrix-app .pms-view-matrix .pms-substance{min-height:104px;padding:12px 10px}#substance-matrix-app .pms-view-matrix .pms-substance-icon{width:48px;height:48px}#substance-matrix-app .pms-view-matrix .pms-substance-name{font-size:.875rem}#substance-matrix-app .pms-view-matrix .pms-single-generated-hint{margin:-2px 0 4px}#substance-matrix-app .pms-dynamic-mobile-nav{display:none}#substance-matrix-app .pms-dynamic-library{display:grid;gap:18px;margin-bottom:22px;padding:22px;border:1px solid rgba(255,255,255,.72);border-radius:22px;background:#ffffffd1;box-shadow:0 16px 34px #0047d81a}#substance-matrix-app .pms-dynamic-library-heading{display:flex;align-items:center;gap:12px}#substance-matrix-app .pms-dynamic-library-icon{display:grid;width:42px;height:42px;flex:0 0 auto;place-items:center;color:var(--pms-primary);background:var(--pms-primary-soft);border-radius:14px}#substance-matrix-app .pms-dynamic-library-icon svg{width:21px;height:21px}#substance-matrix-app .pms-dynamic-library-heading h2{margin:0 0 2px;color:var(--pms-text);font-size:1.125rem;font-weight:900}#substance-matrix-app .pms-dynamic-library-heading p{margin:0;color:#0c2a489e;font-size:.8125rem;font-weight:600}#substance-matrix-app .pms-dynamic-library-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px}#substance-matrix-app .pms-dynamic-library-card{display:grid;min-width:0;min-height:148px;align-content:center;justify-items:center;gap:5px;padding:14px 10px;cursor:pointer;color:var(--pms-text);background:#fff;border:1px solid rgba(0,71,216,.14);border-radius:16px;box-shadow:0 8px 16px #0047d80f;text-align:center;transition:border-color .16s ease,box-shadow .16s ease,background .16s ease}#substance-matrix-app .pms-dynamic-library-card:hover,#substance-matrix-app .pms-dynamic-library-card:focus-visible{background:#f7fbff;border-color:var(--pms-primary);box-shadow:0 12px 22px #0047d81f}#substance-matrix-app .pms-dynamic-library-image{display:grid;width:58px;height:58px;place-items:center}#substance-matrix-app .pms-dynamic-library-image img{width:100%;height:100%;object-fit:contain}#substance-matrix-app .pms-dynamic-library-card strong{overflow-wrap:anywhere;font-size:.9375rem;font-weight:900;line-height:1.15}#substance-matrix-app .pms-dynamic-library-card>span:last-child{color:#0047d894;font-size:.75rem;font-weight:600}@media(max-width:620px){#substance-matrix-app .pms-view-matrix{padding-top:22px}#substance-matrix-app .pms-dynamic-mobile-nav{position:relative;z-index:30;display:flex;align-items:center;justify-content:space-between;margin-bottom:12px}#substance-matrix-app .pms-dynamic-back{display:inline-flex;align-items:center;gap:5px;min-height:38px;padding:0 10px 0 7px;cursor:pointer;color:var(--pms-primary);background:#ffffffb8;border:1px solid rgba(0,71,216,.16);border-radius:10px;box-shadow:0 6px 14px #0047d80f;font-size:.8125rem;font-weight:800}#substance-matrix-app .pms-dynamic-back svg{width:18px;height:18px}#substance-matrix-app .pms-dynamic-menu-toggle{position:relative;z-index:2;margin-left:auto;display:inline-flex;align-items:center;gap:7px;min-height:38px;padding:0 12px;cursor:pointer;color:var(--pms-primary);background:#ffffffd1;border:1px solid rgba(0,71,216,.18);border-radius:10px;box-shadow:0 6px 14px #0047d814;font-size:.8125rem;font-weight:800}#substance-matrix-app .pms-dynamic-menu-toggle svg{width:18px;height:18px}#substance-matrix-app .pms-dynamic-menu{position:absolute;z-index:31;top:calc(100% + 8px);right:0;display:none;width:min(260px,100%);gap:8px;padding:10px;background:#fff;border:1px solid rgba(0,71,216,.16);border-radius:14px;box-shadow:0 16px 30px #0047d829}#substance-matrix-app .pms-dynamic-menu.is-open{display:grid}#substance-matrix-app .pms-dynamic-menu button{display:flex;align-items:center;gap:10px;min-height:48px;padding:0 12px;cursor:pointer;color:var(--pms-text);background:#f7fbff;border:1px solid transparent;border-radius:10px;font-size:.9375rem;font-weight:850;text-align:left}#substance-matrix-app .pms-dynamic-menu button i{display:grid;width:28px;height:28px;place-items:center;color:var(--pms-primary);background:#dbe8ff;border-radius:9px}#substance-matrix-app .pms-dynamic-menu button svg{width:16px;height:16px}#substance-matrix-app .pms-dynamic-menu button:focus-visible,#substance-matrix-app .pms-dynamic-menu button.is-active{color:var(--pms-primary);background:#edf4ff;border-color:#0047d82e}#substance-matrix-app .pms-dynamic-library{gap:16px;padding:16px;border-radius:18px}}@media(min-width:560px){#substance-matrix-app .pms-view-matrix .pms-picker .pms-grid,#substance-matrix-app .pms-view-matrix .pms-picker.is-choosing-second .pms-grid{grid-template-columns:repeat(4,minmax(0,1fr))}}#substance-matrix-app .pms-view-c{width:min(calc(100% - 48px),1180px);padding-top:52px}#substance-matrix-app .pms-view-c .pms-header{max-width:680px;margin-bottom:28px}#substance-matrix-app .pms-view-c .pms-header p{font-size:1.0625rem}#substance-matrix-app .pms-c-equation,#substance-matrix-app .pms-c-picker{margin-bottom:22px;padding:22px;border:1px solid rgba(255,255,255,.72);border-radius:22px;background:#ffffffd1;box-shadow:0 16px 34px #0047d81a}#substance-matrix-app .pms-c-equation-heading,#substance-matrix-app .pms-c-picker-heading{display:flex;align-items:center;justify-content:space-between;gap:16px;margin-bottom:18px}#substance-matrix-app .pms-c-equation-heading h2,#substance-matrix-app .pms-c-picker-heading h2{margin:0;color:var(--pms-text);font-size:1rem;font-weight:900}#substance-matrix-app .pms-c-reset{min-height:34px;padding:6px 10px;cursor:pointer;color:#0c2a48ad;background:transparent;border:1px solid rgba(0,71,216,.16);border-radius:10px;font-size:.75rem;font-weight:800}#substance-matrix-app .pms-c-reset:hover,#substance-matrix-app .pms-c-reset:focus-visible{color:var(--pms-primary);border-color:#0047d86b;background:#fff}#substance-matrix-app .pms-c-equation-flow{display:grid;grid-template-columns:minmax(0,1fr) 34px minmax(0,1fr) 34px minmax(260px,1.42fr);gap:10px;align-items:stretch}#substance-matrix-app .pms-c-operator{display:grid;min-height:196px;place-items:center;color:var(--pms-primary);font-size:2rem;font-weight:900}#substance-matrix-app .pms-c-substance-card,#substance-matrix-app .pms-c-interaction-card{position:relative;display:grid;min-width:0;min-height:196px;align-content:center;justify-items:center;gap:6px;padding:20px;border-radius:16px;text-align:center}#substance-matrix-app .pms-c-substance-card{color:var(--pms-text);background:#fff;border:1.5px solid var(--pms-primary);box-shadow:0 8px 18px #0047d814}#substance-matrix-app button.pms-c-substance-card{width:100%;cursor:pointer}#substance-matrix-app button.pms-c-substance-card:hover,#substance-matrix-app button.pms-c-substance-card:focus-visible,#substance-matrix-app .pms-c-substance-main:hover,#substance-matrix-app .pms-c-substance-main:focus-visible{background:#f7fbff;box-shadow:0 12px 24px #0047d824}#substance-matrix-app .pms-c-substance-card.is-filled{padding:0;overflow:hidden}#substance-matrix-app .pms-c-substance-main{display:grid;width:100%;height:100%;min-height:196px;align-content:center;justify-items:center;gap:6px;padding:20px;cursor:pointer;color:var(--pms-text);background:#fff}#substance-matrix-app .pms-c-card-label{position:absolute;top:12px;left:14px;color:#0c2a4885;font-size:.6875rem;font-weight:800;letter-spacing:0;text-transform:uppercase}#substance-matrix-app .pms-c-empty-icon,#substance-matrix-app .pms-c-interaction-icon{display:grid;width:38px;height:38px;place-items:center;color:var(--pms-primary);background:var(--pms-primary-soft);border-radius:12px}#substance-matrix-app .pms-c-substance-image{display:grid;width:58px;height:58px;place-items:center}#substance-matrix-app .pms-c-substance-image img{width:100%;height:100%;object-fit:contain}#substance-matrix-app .pms-c-substance-card strong,#substance-matrix-app .pms-c-interaction-card strong{font-size:1rem;font-weight:900;line-height:1.18}#substance-matrix-app .pms-c-substance-card.is-filled>span,#substance-matrix-app .pms-c-substance-main>span:last-child{color:#0047d894;font-size:.75rem;font-weight:600}#substance-matrix-app .pms-c-remove{position:absolute;z-index:1;top:10px;right:10px;display:grid;width:30px;height:30px;place-items:center;cursor:pointer;color:#0047d89e;background:#edf3ff;border-radius:999px}#substance-matrix-app .pms-c-remove:hover,#substance-matrix-app .pms-c-remove:focus-visible{color:#fff;background:var(--pms-primary)}#substance-matrix-app .pms-c-remove svg{width:15px;height:15px}#substance-matrix-app .pms-c-interaction-card{justify-items:start;align-content:start;color:var(--pms-text);background:#f7fbff;border:1px solid rgba(0,71,216,.14);text-align:left}#substance-matrix-app .pms-c-interaction-card.is-waiting,#substance-matrix-app .pms-c-interaction-card.is-missing{align-content:center;justify-items:center;color:#0c2a489e;background:#ffffff9e;border-style:dashed;text-align:center}#substance-matrix-app .pms-c-interaction-card.is-waiting .pms-c-card-label,#substance-matrix-app .pms-c-interaction-card.is-missing .pms-c-card-label{left:50%;transform:translate(-50%)}#substance-matrix-app .pms-c-interaction-card p{margin:2px 0 0;color:#0c2a48ad;font-size:.8125rem;font-weight:600;line-height:1.42}#substance-matrix-app .pms-c-interaction-status{display:inline-flex;align-items:center;gap:7px;color:var(--pms-current-risk-ink, var(--pms-primary))}#substance-matrix-app .pms-c-interaction-status svg{width:19px;height:19px}#substance-matrix-app .pms-c-interaction-card.is-ready{border-color:color-mix(in srgb,var(--pms-current-risk) 36%,white)}#substance-matrix-app .pms-c-interaction-card.is-ready button{display:inline-flex;align-items:center;gap:7px;margin-top:auto;padding:0;cursor:pointer;color:var(--pms-primary);background:transparent;font-size:.8125rem;font-weight:900}#substance-matrix-app .pms-c-interaction-card.is-ready button:hover,#substance-matrix-app .pms-c-interaction-card.is-ready button:focus-visible{text-decoration:underline}#substance-matrix-app .pms-c-interaction-card.is-ready button svg{width:16px;height:16px;transform:rotate(180deg)}#substance-matrix-app .pms-c-picker-heading button{display:grid;width:32px;height:32px;place-items:center;cursor:pointer;color:var(--pms-primary);background:#edf3ff;border-radius:999px}#substance-matrix-app .pms-c-picker-heading button:hover,#substance-matrix-app .pms-c-picker-heading button:focus-visible{color:#fff;background:var(--pms-primary)}#substance-matrix-app .pms-c-picker .pms-grid{grid-template-columns:repeat(5,minmax(0,1fr))}#substance-matrix-app .pms-c-details{margin-top:26px;scroll-margin-top:24px}@media(max-width:980px){#substance-matrix-app .pms-view-c{width:min(calc(100% - 40px),760px)}#substance-matrix-app .pms-c-equation-flow{grid-template-columns:minmax(0,1fr) 34px minmax(0,1fr)}#substance-matrix-app .pms-c-equals{grid-column:1 / -1;grid-row:2;min-height:34px}#substance-matrix-app .pms-c-interaction-card{grid-column:1 / -1;grid-row:3;min-height:170px}#substance-matrix-app .pms-c-picker .pms-grid{grid-template-columns:repeat(4,minmax(0,1fr))}}@media(max-width:620px){#substance-matrix-app .pms-view-c{width:min(calc(100% - 28px),512px);padding-top:36px}#substance-matrix-app .pms-c-equation,#substance-matrix-app .pms-c-picker{padding:16px;border-radius:18px}#substance-matrix-app .pms-c-equation-flow{grid-template-columns:minmax(0,1fr);gap:6px}#substance-matrix-app .pms-c-operator,#substance-matrix-app .pms-c-equals,#substance-matrix-app .pms-c-interaction-card{grid-column:auto;grid-row:auto}#substance-matrix-app .pms-c-operator{min-height:30px;font-size:1.625rem}#substance-matrix-app .pms-c-substance-card,#substance-matrix-app .pms-c-substance-main{min-height:152px}#substance-matrix-app .pms-c-interaction-card{min-height:160px}#substance-matrix-app .pms-c-picker .pms-grid{grid-template-columns:repeat(2,minmax(0,1fr))}}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-view-c{padding-top:24px;padding-bottom:24px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-header{margin-bottom:14px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-header .pms-brand{margin-bottom:10px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-header p{font-size:.9375rem;line-height:1.3}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-equation,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker{margin-bottom:12px;padding:14px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-equation-heading,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker-heading{margin-bottom:10px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-card,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-main{min-height:106px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-main{gap:3px;padding:12px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-image{width:38px;height:38px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-card strong{font-size:.875rem}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card{min-height:94px;padding:14px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card p{font-size:.75rem}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-icon{width:30px;height:30px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-operator{min-height:24px;font-size:1.5rem}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker .pms-substance{min-height:82px;padding:9px 8px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker .pms-substance-icon{width:38px;height:38px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker .pms-substance-name{font-size:.75rem}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker .pms-substance-class{font-size:.625rem}@media(min-width:621px)and (max-width:980px){#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-equation-flow{gap:4px}}@media(max-width:620px){#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-card,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-main{min-height:92px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card{min-height:82px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker .pms-grid{grid-template-columns:repeat(3,minmax(0,1fr))}}#substance-matrix-app .pms-c-interaction-card.is-ready{padding-top:42px}#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-card-label{top:12px}#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-interaction-status{min-height:24px}@media(max-width:540px){#substance-matrix-app .pms-c-details .pms-result-header .pms-result-equation{grid-template-columns:minmax(0,1fr);justify-items:start}#substance-matrix-app .pms-c-details .pms-result-header .pms-result-side{justify-self:start}}#substance-matrix-app .pms-c-interaction-card.is-waiting,#substance-matrix-app .pms-c-interaction-card.is-missing{align-content:start;padding-top:48px}#substance-matrix-app .pms-c-interaction-card.is-waiting .pms-c-interaction-icon,#substance-matrix-app .pms-c-interaction-card.is-missing .pms-c-interaction-icon{display:none}#substance-matrix-app .pms-c-interaction-card.is-waiting strong,#substance-matrix-app .pms-c-interaction-card.is-missing strong{margin-top:2px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card.is-waiting,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card.is-missing{min-height:112px;padding:38px 14px 12px}#substance-matrix-app .pms-c-interaction-card.is-ready{display:grid;align-content:start;justify-items:stretch;gap:16px;min-height:0;padding:22px;text-align:left}#substance-matrix-app .pms-c-result-heading{display:grid;gap:6px}#substance-matrix-app .pms-c-result-heading h2{display:flex;align-items:center;gap:9px;margin:0;color:var(--pms-current-risk-ink, var(--pms-text));font-size:1.5rem;font-weight:900;line-height:1.12}#substance-matrix-app .pms-c-result-heading h2 svg{width:24px;height:24px;flex:0 0 auto}#substance-matrix-app .pms-c-result-heading p,#substance-matrix-app .pms-c-fiche-intro p{margin:0;color:#0c2a48bf;font-size:.9rem;font-weight:600;line-height:1.45}#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-fiche-intro{padding:14px 16px;background:#fff;border:1px solid rgba(0,71,216,.1);border-radius:14px}#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-fiche-grid,#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-fiche-why,#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-fiche-help{width:100%}@media(min-width:981px){#substance-matrix-app .pms-c-equation-flow:has(.pms-c-interaction-card.is-ready){grid-template-columns:minmax(210px,1fr) 28px minmax(210px,1fr)}#substance-matrix-app .pms-c-equation-flow:has(.pms-c-interaction-card.is-ready) .pms-c-equals{grid-column:1 / -1;grid-row:2;min-height:32px}#substance-matrix-app .pms-c-equation-flow:has(.pms-c-interaction-card.is-ready) .pms-c-interaction-card{grid-column:1 / -1;grid-row:3}}@media(max-width:620px){#substance-matrix-app .pms-c-interaction-card.is-ready{padding:18px}#substance-matrix-app .pms-c-result-heading h2{font-size:1.28rem}}#substance-matrix-app .pms-view-c .pms-c-substance-main{gap:4px;padding:30px 16px 14px}#substance-matrix-app .pms-view-c .pms-c-substance-image{width:44px;height:44px}#substance-matrix-app .pms-view-c .pms-c-operator,#substance-matrix-app .pms-view-c .pms-c-interaction-card{min-height:152px}@media(min-width:621px)and (max-width:980px){#substance-matrix-app .pms-view-c .pms-c-substance-card,#substance-matrix-app .pms-view-c .pms-c-substance-main,#substance-matrix-app .pms-view-c .pms-c-operator{min-height:142px}#substance-matrix-app .pms-view-c .pms-c-equals{min-height:24px}#substance-matrix-app .pms-view-c .pms-c-interaction-card{min-height:138px}}@media(max-width:620px){#substance-matrix-app .pms-view-c .pms-c-substance-card,#substance-matrix-app .pms-view-c .pms-c-substance-main{min-height:128px}#substance-matrix-app .pms-view-c .pms-c-operator{min-height:28px}#substance-matrix-app .pms-view-c .pms-c-interaction-card{min-height:136px}}#substance-matrix-app .pms-c-interaction-card.is-ready{border:1px solid color-mix(in srgb,var(--pms-current-risk) 35%,white);border-left:4px solid var(--pms-current-risk);background:linear-gradient(90deg,var(--pms-current-risk-soft) 0%,#f8fbff 30%,#f8fbff 100%);box-shadow:0 8px 18px #0047d80f}#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-card-label{color:var(--pms-current-risk-ink)}#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-interaction-status{gap:8px;padding:6px 10px;color:var(--pms-current-risk-ink);background:#fff;border-radius:10px;box-shadow:0 3px 8px color-mix(in srgb,var(--pms-current-risk) 10%,transparent)}#substance-matrix-app .pms-c-interaction-card.is-ready p{max-width:38ch;color:#0c2a48b8;font-weight:650}#substance-matrix-app .pms-c-interaction-card.is-ready button{min-height:30px;padding:4px 0;color:var(--pms-primary);text-decoration:none}#substance-matrix-app .pms-c-interaction-card.is-ready button:hover,#substance-matrix-app .pms-c-interaction-card.is-ready button:focus-visible{text-decoration:none;color:#003fc0}#substance-matrix-app .pms-c-interaction-card.is-ready button svg{transform:rotate(-90deg)}#substance-matrix-app .pms-c-interaction-card.is-ready{background:#f7fbff;border:1px solid rgba(0,71,216,.12);border-left:4px solid var(--pms-current-risk)}#substance-matrix-app .pms-c-details{margin-top:14px}#substance-matrix-app .pms-c-details .pms-result-intro,#substance-matrix-app .pms-c-details .pms-result-equation{display:none}#substance-matrix-app .pms-c-details .pms-result-header.pms-sheet-header{display:block;margin:0 0 8px;padding:2px 4px 0;background:transparent;border:0;box-shadow:none}#substance-matrix-app .pms-c-details .pms-result-header.pms-sheet-header:after{display:none}#substance-matrix-app .pms-c-details .pms-result-header .pms-section-pills{position:static;width:auto;margin:0;padding:0 0 2px;background:transparent}#substance-matrix-app .pms-c-details .pms-substance-sheet-body{gap:10px}#substance-matrix-app .pms-c-details .pms-risk-panel{margin-top:0}#substance-matrix-app .pms-c-details .pms-section-pill{min-height:34px}#substance-matrix-app .pms-c-details #interaction-section-risque,#substance-matrix-app .pms-c-details [data-section-pill=interaction-section-risque]{display:none}#substance-matrix-app .pms-c-details .pms-result-header.pms-sheet-header{margin-bottom:6px;padding:10px 12px 8px;background:#f7fbff;border:1px solid rgba(0,71,216,.12);border-radius:16px;box-shadow:0 6px 16px #0047d80d}#substance-matrix-app .pms-c-details .pms-result-header .pms-section-pills{gap:8px;padding:0}#substance-matrix-app .pms-c-details .pms-result-header .pms-section-pill{min-height:32px;padding:7px 12px;background:#fff;border-color:#0047d824}#substance-matrix-app .pms-c-details .pms-result-header .pms-section-pill.is-active{color:#fff;background:var(--pms-primary);border-color:var(--pms-primary)}#substance-matrix-app .pms-c-details .pms-substance-sheet-body{padding-top:2px}#substance-matrix-app .pms-c-details .pms-section-pills,#substance-matrix-app .pms-c-details .pms-result-header.pms-sheet-header{display:none}#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-interaction-status{padding:0;background:transparent;border-radius:0;box-shadow:none}#substance-matrix-app .pms-c-fiche{display:grid;gap:12px;margin-top:4px;scroll-margin-top:18px}#substance-matrix-app .pms-c-fiche-intro{padding:2px 4px 6px}#substance-matrix-app .pms-c-fiche-intro>span{display:block;margin-bottom:5px;color:var(--pms-current-risk-ink, var(--pms-primary));font-size:.75rem;font-weight:900;line-height:1.2;text-transform:uppercase}#substance-matrix-app .pms-c-fiche-intro h2{margin:0;max-width:62ch;color:var(--pms-text);font-size:1.0625rem;font-weight:800;line-height:1.42}#substance-matrix-app .pms-c-fiche-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px}#substance-matrix-app .pms-c-fiche-section,#substance-matrix-app .pms-c-fiche-why,#substance-matrix-app .pms-c-fiche-temporality,#substance-matrix-app .pms-c-fiche-help{background:#f7fbff;border:1px solid rgba(0,71,216,.12);border-radius:16px;box-shadow:0 8px 18px #0047d80d}#substance-matrix-app .pms-c-fiche-risks{border-left:4px solid var(--pms-current-risk, var(--pms-primary))}#substance-matrix-app .pms-c-fiche-section h3,#substance-matrix-app .pms-c-fiche-temporality h3,#substance-matrix-app .pms-c-fiche-help h3{margin:0 0 10px;color:var(--pms-text);font-size:1rem;font-weight:900;line-height:1.2}#substance-matrix-app .pms-c-fiche-section ul,#substance-matrix-app .pms-c-fiche-section ol{display:grid;gap:9px;margin:0;padding-left:22px;color:#0c2a48d1;font-size:.8125rem;font-weight:600;line-height:1.4}#substance-matrix-app .pms-c-fiche-section li::marker{color:var(--pms-current-risk, var(--pms-primary));font-weight:900}#substance-matrix-app .pms-c-fiche-tips li::marker{color:var(--pms-primary)}#substance-matrix-app .pms-c-fiche-why{padding:0;overflow:hidden}#substance-matrix-app .pms-c-fiche-why summary{display:flex;align-items:center;min-height:54px;padding:14px 18px;cursor:pointer;color:var(--pms-text);font-size:.9375rem;font-weight:850;list-style:none}#substance-matrix-app .pms-c-fiche-why summary::-webkit-details-marker{display:none}#substance-matrix-app .pms-c-fiche-why summary:after{content:"+";margin-left:auto;color:var(--pms-primary);font-size:1.25rem;font-weight:700}#substance-matrix-app .pms-c-fiche-why[open] summary:after{content:"−"}#substance-matrix-app .pms-c-fiche-why p{margin:0;padding:0 18px 16px;color:#0c2a48c7;font-size:.875rem;font-weight:550;line-height:1.48}#substance-matrix-app .pms-c-fiche-help{padding:17px 18px;border-left:4px solid var(--pms-primary);background:#fff}#substance-matrix-app .pms-c-fiche-help p{width:100%;margin:0;color:#0c2a48c7;font-size:.8125rem;font-weight:600;line-height:1.45;text-align:left}#substance-matrix-app .pms-c-fiche-help .pms-c-fiche-emergency{margin-top:9px;padding-top:9px;border-top:1px solid rgba(0,71,216,.12);color:#0c2a48a8;font-size:.75rem}#substance-matrix-app .pms-c-fiche-disclaimer{display:flex;align-items:flex-start;gap:8px;width:100%;margin:2px 0 0;padding:0 4px;color:#0c2a4899;font-size:.75rem;font-weight:600;line-height:1.45}#substance-matrix-app .pms-c-fiche-disclaimer svg{width:16px;height:16px;flex:0 0 auto;margin-top:1px;color:#0047d8a3}#substance-matrix-app .pms-c-fiche-temporality{padding:0;overflow:hidden}#substance-matrix-app .pms-c-fiche-temporality summary{display:flex;align-items:center;gap:8px;min-height:54px;padding:14px 18px;cursor:pointer;color:var(--pms-text);font-size:1rem;font-weight:900;line-height:1.2;list-style:none}#substance-matrix-app .pms-c-fiche-temporality summary::-webkit-details-marker{display:none}#substance-matrix-app .pms-c-fiche-temporality summary:after{content:"+";margin-left:auto;color:var(--pms-primary);font-size:1.25rem;font-weight:700}#substance-matrix-app .pms-c-fiche-temporality[open] summary:after{content:"−"}#substance-matrix-app .pms-c-timeline{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:8px;padding:0 18px 18px}#substance-matrix-app .pms-c-timeline div{position:relative;display:grid;gap:3px;min-width:0}#substance-matrix-app .pms-c-timeline div:not(:last-child):after{content:"";position:absolute;top:28px;left:calc(50% + 15px);width:calc(100% - 20px);height:1px;background:#0047d83d}#substance-matrix-app .pms-c-timeline span{color:#0c2a488f;font-size:.7rem;font-weight:800;text-transform:uppercase}#substance-matrix-app .pms-c-timeline strong{color:var(--pms-text);font-size:.875rem;font-weight:800}@media(max-width:620px){#substance-matrix-app .pms-c-fiche-grid{grid-template-columns:minmax(0,1fr)}#substance-matrix-app .pms-c-fiche-section{padding:16px}}#substance-matrix-app .pms-c-fiche-kicker,#substance-matrix-app .pms-c-fiche-section h3,#substance-matrix-app .pms-c-fiche-help h3{display:flex;align-items:center;gap:8px}#substance-matrix-app .pms-c-fiche-kicker{width:fit-content;padding:4px 8px 4px 5px;border-radius:10px;color:var(--pms-current-risk-ink, #a65300);background:#fff4e6}#substance-matrix-app .pms-c-fiche-icon{display:inline-grid;width:26px;height:26px;flex:0 0 auto;place-items:center;border-radius:9px}#substance-matrix-app .pms-c-fiche-icon svg{width:16px;height:16px;stroke-width:2.4}#substance-matrix-app .pms-c-fiche-icon-spark{color:var(--pms-current-risk-ink, #a65300);background:#ffe3bc}#substance-matrix-app .pms-c-fiche-icon-risk{color:var(--pms-current-risk-ink, #a95400);background:var(--pms-current-risk-soft, #ffedd8)}#substance-matrix-app .pms-c-fiche-icon-tip{color:#00885c;background:#dff9ee}#substance-matrix-app .pms-c-fiche-icon-why{margin-right:9px;color:#0047d8;background:#dbe8ff;vertical-align:middle}#substance-matrix-app .pms-c-fiche-icon-help{color:#d60046;background:#ffe3ed}#substance-matrix-app .pms-c-fiche-icon-time{color:#0047d8;background:#dbe8ff}#substance-matrix-app .pms-c-fiche-section h3,#substance-matrix-app .pms-c-fiche-help h3{margin-bottom:12px}#substance-matrix-app .pms-c-fiche-why summary{gap:0}#substance-matrix-app .pms-c-fiche-intro h2,#substance-matrix-app .pms-c-fiche-risks li,#substance-matrix-app .pms-c-fiche-tips li{padding-left:2px}@media(min-width:981px){#substance-matrix-app .pms-view-c{width:min(calc(100% - 64px),920px)}#substance-matrix-app .pms-view-c .pms-header{max-width:580px}#substance-matrix-app .pms-c-equation-flow{grid-template-columns:minmax(190px,.9fr) 28px minmax(190px,.9fr) 28px minmax(280px,1.15fr);gap:8px}#substance-matrix-app .pms-c-operator{font-size:1.75rem}}#substance-matrix-app .pms-view-result .pms-sheet-header,#substance-matrix-app .pms-view-result .pms-section-pills{position:static}#substance-matrix-app .pms-view-result .pms-result-header.pms-sheet-header{margin-bottom:16px}#substance-matrix-app .pms-view-result .pms-substance-sheet-body{gap:12px}#substance-matrix-app .pms-view-result .pms-flow-nav{margin-top:20px}#substance-matrix-app .pms-view-result .pms-substance-sheet-body>[id]{scroll-margin-top:24px}@media(min-width:621px)and (max-width:980px){#substance-matrix-app .pms-view-c .pms-c-equation-flow{grid-template-columns:minmax(220px,280px) 34px minmax(220px,280px);justify-content:center}#substance-matrix-app .pms-view-c .pms-c-substance-card,#substance-matrix-app .pms-view-c .pms-c-substance-main{min-height:166px}#substance-matrix-app .pms-view-c .pms-c-operator:not(.pms-c-equals){min-height:166px}#substance-matrix-app .pms-view-c .pms-c-equals{min-height:32px}#substance-matrix-app .pms-view-c .pms-c-interaction-card{min-height:122px}}#substance-matrix-app .pms-view-c .pms-c-interaction-card.is-ready{min-height:0}#substance-matrix-app .pms-c-interaction-card.is-ready>p{max-width:none}@media(min-width:621px)and (max-width:980px){#substance-matrix-app .pms-view-c .pms-c-interaction-card.is-ready{min-height:0}}@media(max-width:620px){#substance-matrix-app .pms-view-c .pms-c-interaction-card.is-ready{min-height:0}}#substance-matrix-app .pms-c-interaction-card.is-ready{gap:14px;padding:24px;background:#fff;border:1px solid rgba(0,71,216,.16);border-top:4px solid var(--pms-current-risk);border-left:1px solid rgba(0,71,216,.16);box-shadow:0 14px 28px #0047d817}#substance-matrix-app .pms-c-result-heading{gap:5px;padding-bottom:14px;border-bottom:1px solid rgba(0,71,216,.1)}#substance-matrix-app .pms-c-result-heading .pms-c-card-label{color:var(--pms-current-risk-ink)}#substance-matrix-app .pms-c-result-heading h2{color:var(--pms-current-risk-ink);font-size:1.625rem}#substance-matrix-app .pms-c-result-heading p{color:#0c2a48ad;font-weight:600}#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-fiche-intro{padding:15px 16px;background:var(--pms-current-risk-soft);border:0;border-radius:12px}#substance-matrix-app .pms-c-fiche-intro p{max-width:68ch;color:var(--pms-text);font-size:.9375rem;font-weight:650}#substance-matrix-app .pms-c-fiche-section,#substance-matrix-app .pms-c-fiche-why,#substance-matrix-app .pms-c-fiche-temporality,#substance-matrix-app .pms-c-fiche-help{background:#fbfdff;border:1px solid rgba(0,71,216,.12);box-shadow:none}#substance-matrix-app .pms-c-fiche-section{padding:18px}#substance-matrix-app .pms-c-fiche-risks,#substance-matrix-app .pms-c-fiche-help{border-left:1px solid rgba(0,71,216,.12)}#substance-matrix-app .pms-shell-d{background:linear-gradient(125deg,rgba(0,214,144,.15),transparent 35%),linear-gradient(235deg,rgba(144,0,214,.12),transparent 42%),#edf4ff}#substance-matrix-app .pms-view-d{width:min(calc(100% - 48px),1080px);padding-top:42px}#substance-matrix-app .pms-view-d .pms-header{max-width:760px;margin-bottom:26px}#substance-matrix-app .pms-view-d .pms-brand{margin-bottom:10px}#substance-matrix-app .pms-d-composer,#substance-matrix-app .pms-d-picker,#substance-matrix-app .pms-d-result{border:1px solid rgba(255,255,255,.76);border-radius:24px;background:#ffffffe0;box-shadow:0 16px 38px #0047d81c}#substance-matrix-app .pms-d-composer{padding:26px}#substance-matrix-app .pms-d-composer-heading,#substance-matrix-app .pms-d-picker-heading,#substance-matrix-app .pms-d-result-title-row{display:flex;align-items:center;justify-content:space-between;gap:20px}#substance-matrix-app .pms-d-composer-heading{min-height:52px;margin-bottom:20px}#substance-matrix-app .pms-d-eyebrow,#substance-matrix-app .pms-d-picker-heading span,#substance-matrix-app .pms-d-result-kicker,#substance-matrix-app .pms-d-slot-label{display:block;color:var(--pms-primary);font-size:.72rem;font-weight:800;line-height:1.2;text-transform:uppercase}#substance-matrix-app .pms-d-composer-heading h2,#substance-matrix-app .pms-d-picker-heading h2{margin:4px 0 0;color:var(--pms-text);font-size:1.25rem;font-weight:800;line-height:1.25}#substance-matrix-app .pms-d-reset,#substance-matrix-app .pms-d-picker-heading button{display:inline-grid;min-height:42px;cursor:pointer;place-items:center;padding:9px 14px;color:var(--pms-primary);border:1px solid rgba(0,71,216,.18);border-radius:10px;background:#fff;font-size:.82rem;font-weight:700}#substance-matrix-app .pms-d-picker-heading button{width:42px;padding:0}#substance-matrix-app .pms-d-picker-heading button svg{width:18px;height:18px}#substance-matrix-app .pms-d-reset:hover,#substance-matrix-app .pms-d-reset:focus-visible,#substance-matrix-app .pms-d-picker-heading button:hover,#substance-matrix-app .pms-d-picker-heading button:focus-visible{border-color:var(--pms-primary);background:#f4f8ff;outline:none}#substance-matrix-app .pms-d-equation{display:grid;grid-template-columns:minmax(190px,1fr) 30px minmax(190px,1fr) 30px minmax(210px,.82fr);align-items:stretch;gap:10px}#substance-matrix-app .pms-d-slot,#substance-matrix-app .pms-d-status{position:relative;min-width:0;min-height:176px;border:1.5px solid rgba(0,71,216,.28);border-radius:16px;background:#fff}#substance-matrix-app .pms-d-slot{color:var(--pms-text)}#substance-matrix-app button.pms-d-slot{display:grid;cursor:pointer;place-items:center;align-content:center;gap:9px;padding:18px}#substance-matrix-app .pms-d-slot.is-empty{border-style:dashed;background:#f8fbffdb}#substance-matrix-app .pms-d-slot.is-active{border-color:var(--pms-primary);box-shadow:0 0 0 3px #0047d814}#substance-matrix-app .pms-d-slot-label{position:absolute;top:14px;left:16px;color:#0c2a488c}#substance-matrix-app .pms-d-empty-icon{display:grid;width:42px;height:42px;place-items:center;color:var(--pms-primary);border-radius:12px;background:var(--pms-primary-soft)}#substance-matrix-app .pms-d-empty-icon svg{width:20px;height:20px}#substance-matrix-app .pms-d-slot.is-empty strong{font-size:.96rem;line-height:1.3;text-align:center}#substance-matrix-app .pms-d-slot-main{display:grid;width:100%;height:100%;min-height:174px;cursor:pointer;place-items:center;align-content:center;gap:5px;padding:30px 34px 16px;color:var(--pms-text);border-radius:inherit;background:transparent}#substance-matrix-app .pms-d-substance-image{display:grid;width:54px;height:54px;place-items:center}#substance-matrix-app .pms-d-substance-image img{width:100%;height:100%;object-fit:contain}#substance-matrix-app .pms-d-slot-main strong{max-width:100%;overflow-wrap:anywhere;font-size:1.03rem;line-height:1.2;text-align:center}#substance-matrix-app .pms-d-substance-class{color:var(--pms-secondary);font-size:.78rem;font-weight:600}#substance-matrix-app .pms-d-remove{position:absolute;top:10px;right:10px;display:grid;width:34px;height:34px;cursor:pointer;place-items:center;color:var(--pms-primary);border-radius:50%;background:#edf4ff}#substance-matrix-app .pms-d-remove:hover,#substance-matrix-app .pms-d-remove:focus-visible{color:#fff;background:var(--pms-primary);outline:none}#substance-matrix-app .pms-d-remove svg{width:17px;height:17px}#substance-matrix-app .pms-d-operator{display:grid;min-height:176px;place-items:center;color:var(--pms-primary);font-size:1.75rem;font-weight:800}#substance-matrix-app .pms-d-status{display:grid;align-content:center;justify-items:start;gap:7px;padding:34px 18px 18px;overflow:hidden}#substance-matrix-app .pms-d-status-icon{display:grid;width:34px;height:34px;place-items:center;color:var(--pms-primary);border-radius:10px;background:var(--pms-primary-soft)}#substance-matrix-app .pms-d-status-icon svg{width:18px;height:18px}#substance-matrix-app .pms-d-status strong{font-size:1.05rem;line-height:1.2}#substance-matrix-app .pms-d-status p{margin:0;color:var(--pms-muted);font-size:.76rem;font-weight:600;line-height:1.4}#substance-matrix-app .pms-d-status.is-ready{border-color:color-mix(in srgb,var(--pms-current-risk) 44%,white);border-top:4px solid var(--pms-current-risk);background:#fff}#substance-matrix-app .pms-d-status.is-ready .pms-d-status-icon{color:var(--pms-current-risk-ink);background:var(--pms-current-risk-soft)}#substance-matrix-app .pms-d-status.is-ready strong{color:var(--pms-current-risk-ink)}#substance-matrix-app .pms-d-status a{display:inline-flex;align-items:center;gap:4px;color:var(--pms-primary);font-size:.75rem;font-weight:700;text-decoration:none}#substance-matrix-app .pms-d-status a svg{width:14px;height:14px;transform:rotate(-90deg)}#substance-matrix-app .pms-d-picker{margin-top:18px;padding:22px 24px 24px}#substance-matrix-app .pms-d-picker-heading{min-height:48px;margin-bottom:16px}#substance-matrix-app .pms-d-picker-grid{display:grid;grid-template-columns:repeat(5,minmax(0,1fr));gap:12px}#substance-matrix-app .pms-d-choice{display:grid;min-width:0;min-height:132px;cursor:pointer;place-items:center;align-content:center;gap:4px;padding:12px 8px;color:var(--pms-text);border:1px solid rgba(0,71,216,.11);border-radius:14px;background:#f9fbff}#substance-matrix-app .pms-d-choice:hover,#substance-matrix-app .pms-d-choice:focus-visible{border-color:var(--pms-primary);background:#f1f6ff;outline:none}#substance-matrix-app .pms-d-choice-image{display:grid;width:46px;height:46px;place-items:center}#substance-matrix-app .pms-d-choice-image img{width:100%;height:100%;object-fit:contain}#substance-matrix-app .pms-d-choice strong{max-width:100%;overflow-wrap:anywhere;font-size:.82rem;line-height:1.2;text-align:center}#substance-matrix-app .pms-d-choice>span:last-child{color:var(--pms-secondary);font-size:.68rem;font-weight:500;text-align:center}#substance-matrix-app .pms-d-result{display:grid;gap:16px;margin-top:18px;padding:28px;scroll-margin-top:20px;border-top:5px solid var(--pms-current-risk)}#substance-matrix-app .pms-d-result-header{display:grid;gap:16px}#substance-matrix-app .pms-d-result-title-row h2{margin:5px 0 0;color:var(--pms-text);font-size:1.65rem;font-weight:800;line-height:1.15}#substance-matrix-app .pms-d-result-kicker{color:var(--pms-primary)}#substance-matrix-app .pms-d-risk-badge{display:inline-flex;min-width:158px;min-height:44px;align-items:center;justify-content:center;gap:8px;padding:9px 14px;color:var(--pms-current-risk-ink);border:1px solid color-mix(in srgb,var(--pms-current-risk) 45%,white);border-radius:10px;background:#fff;font-size:.88rem;text-align:center}#substance-matrix-app .pms-d-risk-badge svg{width:18px;height:18px}#substance-matrix-app .pms-d-essential{margin:0;padding:16px 18px;color:var(--pms-text);border-radius:12px;background:var(--pms-current-risk-soft);font-size:1rem;font-weight:600;line-height:1.55}#substance-matrix-app .pms-d-anchors{display:flex;flex-wrap:wrap;gap:8px}#substance-matrix-app .pms-d-anchors a{padding:7px 12px;color:var(--pms-primary);border:1px solid rgba(0,71,216,.16);border-radius:999px;background:#fff;font-size:.76rem;font-weight:700;text-decoration:none}#substance-matrix-app .pms-d-anchors a:hover,#substance-matrix-app .pms-d-anchors a:focus-visible{color:#fff;border-color:var(--pms-primary);background:var(--pms-primary);outline:none}#substance-matrix-app .pms-d-priority-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:14px}#substance-matrix-app .pms-d-info-block,#substance-matrix-app .pms-d-help{padding:20px;border:1px solid rgba(0,71,216,.12);border-radius:14px;background:#f9fbff;scroll-margin-top:20px}#substance-matrix-app .pms-d-info-block h3,#substance-matrix-app .pms-d-help h3{display:flex;align-items:center;gap:10px;margin:0 0 13px;color:var(--pms-text);font-size:1rem;font-weight:800;line-height:1.3}#substance-matrix-app .pms-d-block-icon{display:grid;width:32px;height:32px;flex:0 0 auto;place-items:center;border-radius:9px}#substance-matrix-app .pms-d-block-icon svg{width:17px;height:17px}#substance-matrix-app .pms-d-block-icon.is-risk{color:var(--pms-current-risk-ink);background:var(--pms-current-risk-soft)}#substance-matrix-app .pms-d-block-icon.is-tip{color:#007b55;background:#ddf8ee}#substance-matrix-app .pms-d-block-icon.is-why,#substance-matrix-app .pms-d-block-icon.is-time{color:var(--pms-primary);background:var(--pms-primary-soft)}#substance-matrix-app .pms-d-block-icon.is-help{color:#b0003a;background:#ffe5ed}#substance-matrix-app .pms-d-info-block ul,#substance-matrix-app .pms-d-info-block ol{display:grid;gap:8px;margin:0;padding-left:22px}#substance-matrix-app .pms-d-info-block li,#substance-matrix-app .pms-d-info-block p,#substance-matrix-app .pms-d-help p{color:#0c2a48c7;font-size:.86rem;font-weight:550;line-height:1.5}#substance-matrix-app .pms-d-info-block li::marker{color:var(--pms-primary);font-weight:800}#substance-matrix-app .pms-d-wide-block p,#substance-matrix-app .pms-d-help p{max-width:78ch;margin:0}#substance-matrix-app .pms-d-help{background:#fff8fb;border-color:#d6004624}#substance-matrix-app .pms-d-disclaimer{display:flex;align-items:flex-start;gap:9px;margin:0;padding:2px 4px;color:#0c2a48a3;font-size:.74rem;font-weight:550;line-height:1.5}#substance-matrix-app .pms-d-disclaimer svg{width:17px;height:17px;flex:0 0 auto;margin-top:1px;color:var(--pms-primary)}#substance-matrix-app .pms-d-new-search{width:100%;min-height:48px;cursor:pointer;color:#fff;border-radius:10px;background:var(--pms-primary);font-weight:700}#substance-matrix-app .pms-d-new-search:hover,#substance-matrix-app .pms-d-new-search:focus-visible{background:#0038ad;outline:3px solid rgba(0,71,216,.18)}@media(max-width:900px){#substance-matrix-app .pms-d-equation{grid-template-columns:minmax(0,1fr) 30px minmax(0,1fr)}#substance-matrix-app .pms-d-equals{grid-column:1 / -1;min-height:36px}#substance-matrix-app .pms-d-status{grid-column:1 / -1;min-height:116px}#substance-matrix-app .pms-d-picker-grid{grid-template-columns:repeat(3,minmax(0,1fr))}}@media(max-width:620px){#substance-matrix-app .pms-view-d{width:100%;padding:28px 18px 60px}#substance-matrix-app .pms-view-d .pms-header{margin-bottom:20px}#substance-matrix-app .pms-d-composer,#substance-matrix-app .pms-d-picker,#substance-matrix-app .pms-d-result{border-radius:18px}#substance-matrix-app .pms-d-composer{padding:18px}#substance-matrix-app .pms-d-composer-heading{align-items:flex-start;min-height:58px;margin-bottom:16px}#substance-matrix-app .pms-d-composer-heading h2{font-size:1.08rem}#substance-matrix-app .pms-d-reset{min-height:38px;padding:7px 10px;font-size:.72rem}#substance-matrix-app .pms-d-equation{grid-template-columns:minmax(0,1fr) 24px minmax(0,1fr);gap:8px}#substance-matrix-app .pms-d-slot,#substance-matrix-app .pms-d-slot-main{min-height:132px}#substance-matrix-app .pms-d-slot-main{padding:28px 10px 12px}#substance-matrix-app .pms-d-slot-main strong{overflow-wrap:break-word;font-size:.88rem}#substance-matrix-app .pms-d-operator{min-height:132px;font-size:1.45rem}#substance-matrix-app .pms-d-equals{grid-column:1 / -1;min-height:28px}#substance-matrix-app .pms-d-status{grid-column:1 / -1;min-height:108px;padding:30px 16px 14px}#substance-matrix-app .pms-d-picker{padding:18px}#substance-matrix-app .pms-d-picker-heading h2{font-size:1.05rem}#substance-matrix-app .pms-d-picker-grid{grid-template-columns:repeat(2,minmax(0,1fr))}#substance-matrix-app .pms-d-result{padding:20px 18px}#substance-matrix-app .pms-d-result-title-row{align-items:stretch;flex-direction:column}#substance-matrix-app .pms-d-risk-badge{width:100%}#substance-matrix-app .pms-d-priority-grid{grid-template-columns:minmax(0,1fr)}#substance-matrix-app .pms-d-anchors{display:grid;grid-template-columns:repeat(3,minmax(0,1fr))}#substance-matrix-app .pms-d-anchors a{text-align:center}}@media(max-width:380px){#substance-matrix-app .pms-d-equation{grid-template-columns:minmax(0,1fr)}#substance-matrix-app .pms-d-operator{min-height:28px}#substance-matrix-app .pms-d-equals,#substance-matrix-app .pms-d-status{grid-column:auto}#substance-matrix-app .pms-d-picker-grid{grid-template-columns:minmax(0,1fr)}#substance-matrix-app .pms-d-choice{min-height:112px}}#substance-matrix-app .pms-c-fiche-help{padding:18px;background:#f7faff}#substance-matrix-app .pms-c-fiche-section h3,#substance-matrix-app .pms-c-fiche-help h3{margin-bottom:11px}#substance-matrix-app .pms-c-fiche-why summary{min-height:58px;padding:15px 18px}#substance-matrix-app .pms-c-timeline{gap:0}#substance-matrix-app .pms-c-timeline div{padding:0 12px}#substance-matrix-app .pms-c-timeline div:first-child{padding-left:0}#substance-matrix-app .pms-c-timeline div:last-child{padding-right:0}#substance-matrix-app .pms-c-timeline div:not(:first-child){border-left:1px solid rgba(0,71,216,.2)}#substance-matrix-app .pms-c-timeline div:not(:last-child):after{display:none}@media(max-width:620px){#substance-matrix-app .pms-c-interaction-card.is-ready{display:grid;gap:12px;padding:0;background:transparent;border:0;box-shadow:none}#substance-matrix-app .pms-c-result-heading h2{font-size:1.38rem}#substance-matrix-app .pms-c-result-heading,#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-fiche-intro,#substance-matrix-app .pms-c-fiche-section,#substance-matrix-app .pms-c-fiche-why,#substance-matrix-app .pms-c-fiche-help{padding:18px;background:#fff;border:1px solid rgba(0,71,216,.12);border-radius:16px;box-shadow:0 8px 18px #0047d80f}#substance-matrix-app .pms-c-result-heading{border-top:4px solid var(--pms-current-risk)}#substance-matrix-app .pms-c-interaction-card.is-ready .pms-c-fiche-intro{background:var(--pms-current-risk-soft)}#substance-matrix-app .pms-c-fiche-grid{gap:12px}#substance-matrix-app .pms-c-fiche-why{padding:0}#substance-matrix-app .pms-c-fiche-why summary{padding:16px 18px}}html:has(#substance-matrix-app .pms-shell-c){scrollbar-gutter:stable}#substance-matrix-app .pms-view-c .pms-c-equation-heading{min-height:34px}#substance-matrix-app .pms-view-c .pms-c-equation{margin-bottom:22px;padding:22px}#substance-matrix-app .pms-view-c .pms-c-equation-heading{margin-bottom:18px}#substance-matrix-app .pms-view-c .pms-c-substance-card,#substance-matrix-app .pms-view-c .pms-c-substance-main{min-height:152px}#substance-matrix-app .pms-view-c .pms-c-operator:not(.pms-c-equals){min-height:152px}#substance-matrix-app .pms-view-c .pms-c-equals{min-height:32px}@media(min-width:621px)and (max-width:980px){#substance-matrix-app .pms-view-c .pms-c-substance-card,#substance-matrix-app .pms-view-c .pms-c-substance-main,#substance-matrix-app .pms-view-c .pms-c-operator:not(.pms-c-equals){min-height:166px}}@media(max-width:620px){#substance-matrix-app .pms-view-c .pms-c-equation{padding:16px}#substance-matrix-app .pms-view-c .pms-c-substance-card,#substance-matrix-app .pms-view-c .pms-c-substance-main{min-height:128px}#substance-matrix-app .pms-view-c .pms-c-operator:not(.pms-c-equals){min-height:28px}}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-equation-heading{margin-bottom:18px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-card,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-main{min-height:152px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-operator:not(.pms-c-equals){min-height:152px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card.is-waiting,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card.is-missing{min-height:152px;padding:48px 20px 20px}@media(min-width:621px)and (max-width:980px){#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-card,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-main{min-height:166px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-operator:not(.pms-c-equals){min-height:166px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card.is-waiting,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card.is-missing{min-height:122px}}@media(max-width:620px){#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-equation-heading{margin-bottom:18px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-card,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-main{min-height:128px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-operator:not(.pms-c-equals){min-height:28px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card.is-waiting,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-interaction-card.is-missing{min-height:136px}}#substance-matrix-app .pms-view-c .pms-c-substance-card.is-filled .pms-c-substance-main,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-substance-card.is-filled .pms-c-substance-main{min-height:0;height:100%;box-sizing:border-box}@media(max-width:380px){#substance-matrix-app .pms-view-c .pms-c-picker .pms-grid,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker .pms-grid{grid-template-columns:minmax(0,1fr)}#substance-matrix-app .pms-view-c .pms-c-picker .pms-substance{grid-template-columns:44px minmax(0,1fr);grid-template-rows:auto auto;column-gap:12px;align-items:center;min-height:78px;padding:12px 14px;text-align:left}#substance-matrix-app .pms-view-c .pms-c-picker .pms-substance-icon{grid-row:1 / -1;width:44px;height:44px}#substance-matrix-app .pms-view-c .pms-c-picker .pms-substance-name,#substance-matrix-app .pms-view-c .pms-c-picker .pms-substance-class{justify-self:start}}#substance-matrix-app .pms-view-c .pms-header .pms-brand{margin-bottom:0}#substance-matrix-app .pms-view-c .pms-header p{font-size:1.0625rem;line-height:1.45}#substance-matrix-app .pms-view-c button.pms-c-substance-card.is-empty{display:grid;align-content:center;justify-items:center;gap:5px;padding:24px 16px;color:#2d51a0cc;background:#ffffff94;border:2px dashed rgba(45,81,160,.34);box-shadow:none}#substance-matrix-app .pms-d-result:focus{outline:none}#substance-matrix-app .pms-view-c button.pms-c-substance-card.is-empty .pms-c-card-label{display:none}#substance-matrix-app .pms-view-c button.pms-c-substance-card.is-empty strong{color:#2d51a0d1;font-size:1rem}#substance-matrix-app .pms-view-c .pms-c-empty-choice{color:#0c2a4873;font-size:.875rem;font-weight:600}#substance-matrix-app .pms-view-c button.pms-c-substance-card.is-empty:hover,#substance-matrix-app .pms-view-c button.pms-c-substance-card.is-empty:focus-visible{color:var(--pms-primary);background:#ffffffe0;border-color:#0047d894;box-shadow:0 8px 18px #0047d814}#substance-matrix-app .pms-view-c .pms-c-substance-card.is-filled{transition:border-color .16s ease,box-shadow .16s ease}#substance-matrix-app .pms-view-c .pms-c-substance-card.is-filled .pms-c-substance-main{transition:background .16s ease}#substance-matrix-app .pms-view-c .pms-c-substance-card.is-filled:hover,#substance-matrix-app .pms-view-c .pms-c-substance-card.is-filled:focus-within{border-color:var(--pms-primary);box-shadow:0 10px 20px #0047d821}#substance-matrix-app .pms-view-c .pms-c-substance-card.is-filled .pms-c-substance-main:hover,#substance-matrix-app .pms-view-c .pms-c-substance-card.is-filled .pms-c-substance-main:focus-visible{background:#fff;box-shadow:none;outline:none}#substance-matrix-app .pms-view-c .pms-c-operator{font-size:2rem;line-height:1}@media(min-width:981px){#substance-matrix-app .pms-view-c .pms-c-operator{font-size:1.75rem}}@media(max-width:620px){#substance-matrix-app .pms-view-c .pms-c-operator{font-size:1.625rem}}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-view-c{padding-top:52px;padding-bottom:0}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-header{margin-bottom:28px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-header .pms-brand{margin-bottom:0}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-header p{font-size:1.0625rem;line-height:1.45}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-equation,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker{margin-bottom:22px;padding:22px}@media(max-width:620px){#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-view-c{padding-top:36px}#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-equation,#substance-matrix-app .pms-shell-c.pms-c-is-selecting .pms-c-picker{padding:16px}}#substance-matrix-app .pms-view-c .pms-c-operator,#substance-matrix-app .pms-view-c .pms-c-operator.pms-c-equals{font-size:1.5rem!important;line-height:1!important}@media(max-width:620px){#substance-matrix-app .pms-view-c .pms-c-operator,#substance-matrix-app .pms-view-c .pms-c-operator.pms-c-equals{font-size:1.375rem!important}}#substance-matrix-app .pms-view-c .pms-c-equation-heading.is-result{justify-content:flex-end}#substance-matrix-app .pms-shell-d{--pms-d-blue: #064ee8;--pms-d-blue-dark: #0039bd;--pms-d-blue-pale: #eaf1ff;--pms-d-lilac: #f0ecff;--pms-d-red: #ff2020;--pms-d-copy: #111111;background:linear-gradient(128deg,#ffcc6373,#fff0 27%),linear-gradient(224deg,#064ee8b8,#997dff80 25%,#fff0 52%),#fff}#substance-matrix-app .pms-shell-d.pms-risk-theme-3{--pms-current-risk: var(--pms-d-red);--pms-current-risk-soft: #fff0f0;--pms-current-risk-ink: #d90000}#substance-matrix-app .pms-shell-d .pms-bg-doodles{display:none}#substance-matrix-app .pms-view-d{width:min(calc(100% - 56px),1120px);padding-top:52px}#substance-matrix-app .pms-d-header{max-width:900px;margin-bottom:42px}#substance-matrix-app .pms-d-title-pill{display:inline-flex;align-items:center;min-height:42px;margin-bottom:18px;padding:5px 22px;color:var(--pms-d-blue);border:3px solid var(--pms-d-blue);border-radius:999px;background:#ffffffc2;font-size:1.42rem;font-weight:700;line-height:1}#substance-matrix-app .pms-shell-d .pms-d-title-pill{background:transparent}#substance-matrix-app .pms-d-header h1{max-width:100%;margin:0 0 18px;color:var(--pms-d-blue);font-size:3.35rem;font-weight:800;line-height:1.02}#substance-matrix-app .pms-d-header p{max-width:760px;margin:0;color:var(--pms-d-copy);font-size:1.2rem;font-weight:400;line-height:1.55}#substance-matrix-app .pms-d-composer,#substance-matrix-app .pms-d-picker{border:0;border-radius:24px;background:var(--pms-d-blue-pale);box-shadow:0 18px 40px #064ee829}#substance-matrix-app .pms-d-composer{padding:32px 38px 38px}#substance-matrix-app .pms-d-composer-heading{position:relative;justify-content:center;min-height:46px;margin-bottom:26px}#substance-matrix-app .pms-d-composer-heading h2{margin:0;color:var(--pms-d-blue);font-size:1.45rem;text-align:center}#substance-matrix-app .pms-d-reset{position:absolute;top:0;right:0;color:var(--pms-d-blue);border-color:#064ee838;background:#ffffffe0}#substance-matrix-app .pms-d-equation{grid-template-columns:minmax(220px,1fr) 44px minmax(220px,1fr);justify-content:center;gap:14px}#substance-matrix-app .pms-d-slot,#substance-matrix-app .pms-d-status{min-height:210px;border:2px solid rgba(6,78,232,.28);border-radius:18px;background:#fff;box-shadow:0 10px 20px #2c316029}#substance-matrix-app .pms-d-slot.is-empty{border:2px dotted var(--pms-d-blue);background:#fff}#substance-matrix-app .pms-d-slot.is-filled{border-color:transparent;background:var(--pms-d-lilac);box-shadow:0 10px 24px #6f54d640}#substance-matrix-app .pms-d-slot.is-active{border-color:var(--pms-d-blue);box-shadow:0 0 0 3px #064ee81a,0 10px 24px #6f54d640}#substance-matrix-app .pms-d-slot-label{top:16px;left:18px;color:#064ee880}#substance-matrix-app .pms-d-empty-icon{width:48px;height:48px;color:var(--pms-d-blue);border-radius:50%;background:var(--pms-d-blue-pale)}#substance-matrix-app .pms-d-slot.is-empty strong{color:var(--pms-d-blue);font-size:1.08rem}#substance-matrix-app .pms-d-slot-main{min-height:208px;gap:6px;padding:34px 22px 18px}#substance-matrix-app .pms-d-substance-image{width:82px;height:82px}#substance-matrix-app .pms-d-slot-main strong{color:var(--pms-d-blue);font-size:1.22rem}#substance-matrix-app .pms-d-substance-class{color:#4b86ff;font-size:.88rem;font-weight:500}#substance-matrix-app .pms-d-remove{color:var(--pms-d-blue);background:#ffffffc7}#substance-matrix-app .pms-d-operator{min-height:210px;color:var(--pms-d-blue);font-size:2.25rem}#substance-matrix-app .pms-d-equals{grid-column:1 / -1;min-height:42px}#substance-matrix-app .pms-d-status{grid-column:1 / -1;width:min(100%,340px);min-height:170px;justify-self:center;align-content:center;justify-items:center;padding:28px;text-align:center}#substance-matrix-app .pms-d-status .pms-d-slot-label{position:static;color:#064ee880}#substance-matrix-app .pms-d-status-icon{display:none}#substance-matrix-app .pms-d-status strong{color:var(--pms-d-blue);font-size:1.28rem}#substance-matrix-app .pms-d-status p{max-width:230px;color:#1111116b;font-size:.84rem;font-weight:500}#substance-matrix-app .pms-d-status.is-ready{width:min(100%,292px);min-height:210px;align-content:start;justify-items:start;gap:6px;padding:22px 28px 20px;border:0;border-top:0;border-radius:18px;background:#fff;box-shadow:0 14px 25px #2c316038;text-align:left}#substance-matrix-app .pms-d-status.is-ready .pms-d-slot-label{width:100%;margin-bottom:10px;color:var(--pms-d-blue);font-size:1.12rem;font-weight:700;text-align:center;text-transform:none}#substance-matrix-app .pms-d-status.is-ready strong{color:var(--pms-current-risk-ink);font-size:1.05rem;line-height:1.25}#substance-matrix-app .pms-d-status.is-ready p{max-width:100%;color:#11111175;font-size:.86rem;font-weight:500;line-height:1.45}#substance-matrix-app .pms-d-status a{display:grid;width:100%;justify-items:center;gap:7px;margin-top:auto;color:#4384ff;font-size:.84rem;text-align:center}#substance-matrix-app .pms-d-picker{margin-top:38px;padding:28px 32px 32px;background:#ffffffe6}#substance-matrix-app .pms-d-picker-heading span{color:var(--pms-d-blue)}#substance-matrix-app .pms-d-picker-heading h2{color:var(--pms-d-blue);font-size:1.4rem}#substance-matrix-app .pms-d-picker-grid{gap:18px}#substance-matrix-app .pms-d-choice{min-height:172px;gap:7px;border:0;border-radius:16px;background:var(--pms-d-lilac);box-shadow:0 9px 18px #6f54d633}#substance-matrix-app .pms-d-choice:hover,#substance-matrix-app .pms-d-choice:focus-visible{border-color:transparent;background:#e6dfff;box-shadow:0 0 0 3px #064ee821,0 9px 18px #6f54d640}#substance-matrix-app .pms-d-choice-image{width:68px;height:68px}#substance-matrix-app .pms-d-choice strong{color:var(--pms-d-blue);font-size:.94rem}#substance-matrix-app .pms-d-choice>span:last-child{color:#4b86ff;font-size:.76rem}#substance-matrix-app .pms-d-result{gap:24px;margin-top:52px;padding:0 0 20px;border:0;border-radius:0;background:transparent;box-shadow:none}#substance-matrix-app .pms-d-result-header{gap:18px}#substance-matrix-app .pms-d-takeaway-title{width:fit-content;margin:0;padding:8px 18px;color:#fff;border-radius:999px;background:var(--pms-d-blue);box-shadow:0 5px 10px #064ee83d;font-size:1.25rem;font-weight:700;line-height:1.1}#substance-matrix-app .pms-d-essential{max-width:980px;padding:0;color:var(--pms-d-copy);background:transparent;font-size:1.08rem;font-weight:400;line-height:1.62}#substance-matrix-app .pms-d-anchors a{color:var(--pms-d-blue);border-color:#064ee82e;background:#ffffffe0}#substance-matrix-app .pms-d-priority-grid{gap:22px}#substance-matrix-app .pms-d-info-block,#substance-matrix-app .pms-d-help{padding:26px;border:0;border-radius:20px;background:#fffffff0;box-shadow:0 10px 28px #064ee824}#substance-matrix-app .pms-d-info-block h3,#substance-matrix-app .pms-d-help h3{color:var(--pms-d-blue);font-size:1.16rem}#substance-matrix-app .pms-d-info-block p,#substance-matrix-app .pms-d-info-block li,#substance-matrix-app .pms-d-help p{color:var(--pms-d-copy);font-weight:400}#substance-matrix-app .pms-d-info-block li::marker{color:var(--pms-d-blue)}#substance-matrix-app .pms-d-info-block:first-child{box-shadow:0 10px 28px #ff20202e}#substance-matrix-app .pms-d-info-block:first-child h3,#substance-matrix-app .pms-d-info-block:first-child li::marker{color:var(--pms-d-red)}#substance-matrix-app .pms-d-block-icon{display:none}#substance-matrix-app .pms-d-wide-block,#substance-matrix-app .pms-d-help{min-height:110px}#substance-matrix-app .pms-d-help{background:#fffffff0}#substance-matrix-app .pms-d-disclaimer{color:#11111194}#substance-matrix-app .pms-d-new-search{background:var(--pms-d-blue)}#substance-matrix-app .pms-d-new-search:hover,#substance-matrix-app .pms-d-new-search:focus-visible{background:var(--pms-d-blue-dark)}@media(max-width:900px){#substance-matrix-app .pms-d-header h1{font-size:2.75rem}#substance-matrix-app .pms-d-equation{grid-template-columns:minmax(0,1fr) 34px minmax(0,1fr)}#substance-matrix-app .pms-d-picker-grid{grid-template-columns:repeat(3,minmax(0,1fr))}}@media(max-width:620px){#substance-matrix-app .pms-view-d{width:100%;padding:30px 18px 60px}#substance-matrix-app .pms-d-header{margin-bottom:28px}#substance-matrix-app .pms-d-title-pill{min-height:34px;margin-bottom:12px;padding:4px 15px;border-width:2px;font-size:1rem}#substance-matrix-app .pms-d-header h1{margin-bottom:12px;font-size:2.05rem}#substance-matrix-app .pms-d-header p{font-size:.98rem;line-height:1.5}#substance-matrix-app .pms-d-composer{padding:20px 16px 22px}#substance-matrix-app .pms-d-composer-heading{justify-content:flex-start;margin-bottom:18px}#substance-matrix-app .pms-d-composer-heading h2{max-width:160px;font-size:1.05rem;text-align:left}#substance-matrix-app .pms-d-reset{min-height:36px}#substance-matrix-app .pms-d-slot,#substance-matrix-app .pms-d-slot-main,#substance-matrix-app .pms-d-operator{min-height:142px}#substance-matrix-app .pms-d-slot-main{padding:28px 8px 12px}#substance-matrix-app .pms-d-substance-image{width:58px;height:58px}#substance-matrix-app .pms-d-slot-main strong{font-size:.9rem}#substance-matrix-app .pms-d-slot.is-empty strong{max-width:116px;font-size:.84rem;line-height:1.25}#substance-matrix-app .pms-d-slot-label{top:12px;left:12px;font-size:.6rem}#substance-matrix-app .pms-d-equals{min-height:30px}#substance-matrix-app .pms-d-status{width:100%;min-height:122px}#substance-matrix-app .pms-d-status.is-ready{width:min(100%,270px);min-height:205px;padding:20px 22px 18px}#substance-matrix-app .pms-d-picker{margin-top:22px;padding:20px 16px}#substance-matrix-app .pms-d-picker-grid{grid-template-columns:repeat(2,minmax(0,1fr));gap:12px}#substance-matrix-app .pms-d-choice{min-height:142px}#substance-matrix-app .pms-d-result{margin-top:34px}#substance-matrix-app .pms-d-takeaway-title{font-size:1.05rem}#substance-matrix-app .pms-d-priority-grid{grid-template-columns:minmax(0,1fr)}#substance-matrix-app .pms-d-info-block,#substance-matrix-app .pms-d-help{padding:20px;border-radius:16px}}#substance-matrix-app .pms-d-status.is-waiting{width:min(100%,292px);min-height:210px;gap:6px;padding:22px 28px 20px}#substance-matrix-app .pms-d-status.is-waiting strong{font-size:1.08rem}#substance-matrix-app .pms-d-status.is-waiting p{margin-top:2px}@media(max-width:620px){#substance-matrix-app .pms-d-status.is-waiting{width:min(100%,270px);min-height:205px;padding:20px 22px 18px}}#substance-matrix-app .pms-view-e{width:min(calc(100% - 56px),960px)}#substance-matrix-app .pms-e-header{margin-bottom:30px}#substance-matrix-app .pms-e-directory{display:grid;gap:28px;padding:30px;border-radius:22px;background:var(--pms-d-blue-pale);box-shadow:0 18px 40px #064ee829}#substance-matrix-app .pms-e-directory-heading span{display:block;margin-bottom:4px;color:var(--pms-d-blue);font-size:.72rem;font-weight:800;text-transform:uppercase}#substance-matrix-app .pms-e-directory-heading h2{margin:0;color:var(--pms-d-blue);font-size:1.55rem;font-weight:800;line-height:1.2}#substance-matrix-app .pms-e-tag-section{display:grid;gap:13px}#substance-matrix-app .pms-e-tag-section h3{margin:0;color:var(--pms-d-copy);font-size:.9rem;font-weight:700}#substance-matrix-app .pms-e-tags{display:flex;flex-wrap:wrap;gap:10px}#substance-matrix-app .pms-e-tag{display:inline-flex;min-height:50px;cursor:pointer;align-items:center;justify-content:center;gap:9px;padding:10px 18px;color:var(--pms-d-blue);border:1.5px solid rgba(6,78,232,.2);border-radius:999px;background:#fff;box-shadow:0 4px 10px #064ee814;font-size:.9rem;font-weight:700;line-height:1.2;text-align:center;transition:border-color .16s ease,background-color .16s ease,box-shadow .16s ease,transform .16s ease}#substance-matrix-app .pms-e-tag img{width:28px;height:28px;flex:0 0 auto;object-fit:contain}#substance-matrix-app .pms-e-substance-tag[data-substance-id=cocaine] img{width:42px}#substance-matrix-app .pms-e-substance-tag:not(.is-active):hover,#substance-matrix-app .pms-e-substance-tag:not(.is-active):focus-visible{color:#fff;border-color:var(--pms-d-blue);background:var(--pms-d-blue);box-shadow:0 8px 18px #064ee83d;transform:translateY(-1px)}#substance-matrix-app .pms-e-substance-tag:not(.is-active):hover img,#substance-matrix-app .pms-e-substance-tag:not(.is-active):focus-visible img{filter:brightness(0) invert(1)}#substance-matrix-app .pms-e-tag:hover,#substance-matrix-app .pms-e-tag:focus-visible{color:var(--pms-d-blue-dark);border-color:var(--pms-d-blue);background:var(--pms-d-lilac);outline:none}#substance-matrix-app .pms-e-tag.is-active{color:#fff;border-color:var(--pms-d-blue);background:var(--pms-d-blue);box-shadow:0 5px 12px #064ee840}#substance-matrix-app .pms-e-tag.is-active img{filter:brightness(0) invert(1)}#substance-matrix-app .pms-e-substance-tag.is-active{color:#fff;border-color:var(--pms-d-blue);background:var(--pms-d-blue);box-shadow:0 5px 12px #064ee840}#substance-matrix-app .pms-e-substance-tag.is-active img{filter:brightness(0) invert(1)}#substance-matrix-app .pms-e-substance-tag.is-active:hover,#substance-matrix-app .pms-e-substance-tag.is-active:focus-visible{color:#fff;background:var(--pms-d-blue);box-shadow:0 8px 18px #064ee83d}#substance-matrix-app .pms-e-substance-tag.is-active:hover img,#substance-matrix-app .pms-e-substance-tag.is-active:focus-visible img{filter:brightness(0) invert(1)}#substance-matrix-app .pms-e-interaction-tag{min-height:46px;padding-inline:17px;color:#3e269c;border-color:#6f54d638;background:var(--pms-d-lilac)}#substance-matrix-app .pms-e-interaction-tag:hover,#substance-matrix-app .pms-e-interaction-tag:focus-visible{color:#fff;border-color:#6543d8;background:#6543d8}#substance-matrix-app .pms-e-interaction-tag.is-active{border-color:#6543d8;background:#6543d8}#substance-matrix-app .pms-e-empty{display:flex;min-height:120px;align-items:center;justify-content:center;gap:10px;margin-top:24px;color:#11111194;border:2px solid transparent;border-radius:18px;background:linear-gradient(#fff,#fff) padding-box,linear-gradient(110deg,#0047d8,#00b7e8,#00d690,#ffd447,#d60046,#9000d6,#0047d8) border-box;background-size:100% 100%,280% 100%;box-shadow:0 8px 22px #0047d814;animation:pms-e-rainbow-border 9s linear infinite;transition:box-shadow .18s ease,transform .18s ease}#substance-matrix-app .pms-e-empty:hover{box-shadow:0 12px 28px #0047d829;animation-duration:3.6s;transform:translateY(-1px)}#substance-matrix-app .pms-e-empty>span{display:grid;width:34px;height:34px;place-items:center;color:var(--pms-d-blue);border-radius:50%;background:var(--pms-d-blue-pale)}#substance-matrix-app .pms-e-empty p{margin:0;font-size:.88rem;font-weight:600}@keyframes pms-e-rainbow-border{to{background-position:0 0,280% 0}}@media(prefers-reduced-motion:reduce){#substance-matrix-app .pms-e-empty{animation:none}}#substance-matrix-app .pms-e-result,#substance-matrix-app .pms-e-substance-result{margin-top:34px}#substance-matrix-app .pms-e-result{gap:22px}#substance-matrix-app .pms-e-result-lead{position:relative;display:grid;gap:20px;padding:28px 32px;border-radius:24px;background:#fff;box-shadow:0 12px 30px #064ee81f}#substance-matrix-app .pms-e-result.has-animated-risk-border .pms-e-result-lead:after{position:absolute;pointer-events:none;content:"";top:0;right:0;bottom:0;left:0;border:2px solid var(--pms-current-risk);border-radius:inherit;animation:pms-e-risk-border-pulse 2.4s ease-in-out infinite}@keyframes pms-e-risk-border-pulse{0%,to{opacity:0}45%,60%{opacity:1}}#substance-matrix-app .pms-e-result-summary{display:grid;grid-template-columns:minmax(0,1fr) auto;align-items:center;gap:28px}#substance-matrix-app .pms-e-result-copy{display:grid;min-width:0;gap:10px}#substance-matrix-app .pms-e-result-risk{display:inline-flex;width:fit-content;align-items:center;gap:7px;color:var(--pms-current-risk-ink);font-size:.82rem;font-weight:700}#substance-matrix-app .pms-e-result-risk svg{width:17px;height:17px}#substance-matrix-app .pms-e-result-copy h2{margin:0;color:var(--pms-d-blue);font-size:2.25rem;font-weight:800;line-height:1.08}#substance-matrix-app .pms-e-result-copy h2 b{color:var(--pms-d-blue)}#substance-matrix-app .pms-e-result-copy p{max-width:680px;margin:0;color:#555d70;font-size:1rem;font-weight:400;line-height:1.65}#substance-matrix-app .pms-e-result-visuals{display:flex;align-items:center;justify-content:flex-end;gap:10px}#substance-matrix-app .pms-e-result-visuals>span{display:grid;width:76px;height:76px;place-items:center}#substance-matrix-app .pms-e-result-substance-image{width:100%;height:100%;object-fit:contain}#substance-matrix-app .pms-e-result-nav{margin-top:0}#substance-matrix-app .pms-e-result .pms-d-info-block h3,#substance-matrix-app .pms-e-result .pms-d-info-block:first-child h3,#substance-matrix-app .pms-e-result .pms-d-help h3{display:flex;align-items:center;justify-content:flex-start;gap:14px;margin:0 0 15px;color:var(--pms-d-blue);font-size:1.25rem;font-weight:800;line-height:1.25}#substance-matrix-app .pms-e-result .pms-d-info-block:first-child h3{color:var(--pms-d-red)}#substance-matrix-app .pms-e-section-title-icon{display:inline-grid;width:30px;height:30px;flex:0 0 30px;place-items:center;color:var(--pms-d-blue);border-radius:9px;background:var(--pms-d-blue-pale)}#substance-matrix-app .pms-e-section-title-icon svg{width:17px;height:17px}#substance-matrix-app .pms-e-result .pms-d-info-block:first-child .pms-e-section-title-icon{color:var(--pms-d-red);background:#ffe9ef}#substance-matrix-app .pms-e-result .pms-d-info-block p,#substance-matrix-app .pms-e-result .pms-d-info-block li,#substance-matrix-app .pms-e-result .pms-d-help p{color:#555d70;font-size:1rem;font-weight:400;line-height:1.65}#substance-matrix-app .pms-e-result .pms-d-info-block li::marker,#substance-matrix-app .pms-e-result .pms-d-info-block:first-child li::marker{color:var(--pms-d-blue);font-weight:700}#substance-matrix-app .pms-e-result .pms-d-disclaimer{color:#1119;font-size:.84rem;line-height:1.55}#substance-matrix-app .pms-e-substance-sheet{display:grid;gap:24px;width:100%;margin-top:34px}#substance-matrix-app .pms-e-substance-header{display:flex;min-height:172px;align-items:center;justify-content:space-between;gap:28px;padding:28px 32px;border-radius:24px;background:#fffffff5;box-shadow:0 14px 34px #064ee824}#substance-matrix-app .pms-e-substance-heading{display:grid;min-width:0;gap:20px}#substance-matrix-app .pms-e-substance-heading h2{margin:0;color:var(--pms-d-blue);font-size:2.25rem;font-weight:800;line-height:1.08}#substance-matrix-app .pms-e-substance-nav{display:flex;flex-wrap:wrap;gap:9px}#substance-matrix-app .pms-e-substance-nav a{display:inline-flex;min-height:38px;align-items:center;justify-content:center;padding:6px 16px;color:#4b86ff;border:1.5px solid #4b86ff;border-radius:999px;background:#fff;font-size:.9rem;font-weight:600;line-height:1;text-decoration:none;transition:color .15s ease,background-color .15s ease,box-shadow .15s ease}#substance-matrix-app .pms-e-substance-nav a:hover,#substance-matrix-app .pms-e-substance-nav a:focus-visible,#substance-matrix-app .pms-e-substance-nav a.is-active{color:#fff;background:var(--pms-d-blue);box-shadow:0 5px 12px #064ee833}#substance-matrix-app .pms-e-substance-visual{display:grid;width:112px;height:112px;flex:0 0 112px;place-items:center}#substance-matrix-app .pms-e-substance-visual .pms-substance-image{width:100%;height:100%;object-fit:contain}#substance-matrix-app .pms-e-substance-sections{display:grid;gap:20px}#substance-matrix-app .pms-e-substance-section{padding:28px 32px;scroll-margin-top:24px;border-radius:22px;background:#fff;box-shadow:0 10px 28px #064ee81c}#substance-matrix-app .pms-e-substance-section h3{margin:0 0 15px;color:var(--pms-d-blue);font-size:1.25rem;font-weight:800;line-height:1.25}#substance-matrix-app .pms-e-substance-section p,#substance-matrix-app .pms-e-substance-section li{color:#555d70;font-size:1rem;font-weight:400;line-height:1.65}#substance-matrix-app .pms-e-substance-section p+p{margin-top:12px}#substance-matrix-app .pms-e-substance-section ul{display:grid;gap:7px;margin:15px 0 0;padding-left:22px}#substance-matrix-app .pms-e-substance-section li::marker{color:var(--pms-d-blue)}#substance-matrix-app .pms-e-substance-section.is-aide{background:#fff}#substance-matrix-app .pms-e-substance-section.is-aide h3{color:var(--pms-d-blue)}#substance-matrix-app .pms-e-substance-section.is-temporalite h3{display:flex;align-items:center;gap:10px}#substance-matrix-app .pms-e-substance-section.is-temporalite h3 svg{width:20px;height:20px;flex:0 0 20px}#substance-matrix-app .pms-e-substance-timeline{position:relative;display:grid;grid-template-columns:repeat(3,minmax(0,1fr));margin-top:22px}#substance-matrix-app .pms-e-substance-timeline:before{position:absolute;top:30px;right:16.666%;left:16.666%;height:2px;content:"";background:#cbdcff}#substance-matrix-app .pms-e-timeline-step{position:relative;z-index:1;display:grid;justify-items:center;gap:8px;min-width:0;text-align:center}#substance-matrix-app .pms-e-timeline-step span{color:#748199;font-size:.76rem;font-weight:700;line-height:1;text-transform:uppercase}#substance-matrix-app .pms-e-timeline-step i{display:block;width:14px;height:14px;border:3px solid #ffffff;border-radius:50%;background:var(--pms-d-blue);box-shadow:0 0 0 2px #b9ceff}#substance-matrix-app .pms-e-timeline-step strong{color:var(--pms-d-blue);font-size:1rem;font-weight:800;line-height:1.2;white-space:nowrap}#substance-matrix-app .pms-e-organ-tags{display:flex;flex-wrap:wrap;gap:10px}#substance-matrix-app .pms-e-organ-tags span{display:inline-flex;min-height:38px;align-items:center;padding:7px 14px;color:var(--pms-d-blue);border-radius:999px;background:var(--pms-d-blue-pale);font-size:.88rem;font-weight:700}#substance-matrix-app .pms-e-substance-disclaimer{display:flex;align-items:flex-start;gap:12px;padding:22px 26px;color:#1119;border-radius:20px;background:#fff;box-shadow:0 10px 28px #064ee81a}#substance-matrix-app .pms-e-substance-disclaimer svg{width:19px;height:19px;flex:0 0 auto;color:var(--pms-d-blue)}#substance-matrix-app .pms-e-substance-disclaimer p{margin:0;font-size:.84rem;line-height:1.55}@media(max-width:620px){#substance-matrix-app .pms-view-e{width:100%}#substance-matrix-app .pms-e-directory{gap:24px;padding:22px 18px;border-radius:18px}#substance-matrix-app .pms-e-directory-heading h2{font-size:1.28rem}#substance-matrix-app .pms-e-tags{display:grid;grid-template-columns:repeat(2,minmax(0,1fr))}#substance-matrix-app .pms-e-tag{width:100%;min-height:48px;min-width:0;gap:7px;padding-inline:8px;font-size:.78rem;white-space:nowrap}#substance-matrix-app .pms-e-tag img{width:24px;height:24px}#substance-matrix-app .pms-e-substance-tag[data-substance-id=cocaine] img{width:36px}#substance-matrix-app .pms-e-interaction-tag{min-height:46px;font-size:.84rem;white-space:normal}#substance-matrix-app .pms-e-interaction-tags{grid-template-columns:minmax(0,1fr)}#substance-matrix-app .pms-e-result-lead{gap:14px;padding:22px 20px;border-radius:18px}#substance-matrix-app .pms-e-result-summary{grid-template-columns:minmax(0,1fr) 112px;align-items:start;gap:12px}#substance-matrix-app .pms-e-result-copy{display:contents}#substance-matrix-app .pms-e-result-risk{grid-column:1;grid-row:1;font-size:.76rem}#substance-matrix-app .pms-e-result-copy h2{grid-column:1;grid-row:2;font-size:1.7rem}#substance-matrix-app .pms-e-result-copy p{grid-column:1 / -1;grid-row:3;font-size:.9rem;line-height:1.58}#substance-matrix-app .pms-e-result .pms-d-info-block h3,#substance-matrix-app .pms-e-result .pms-d-info-block:first-child h3,#substance-matrix-app .pms-e-result .pms-d-help h3{margin-bottom:12px;font-size:1.08rem}#substance-matrix-app .pms-e-result .pms-d-info-block p,#substance-matrix-app .pms-e-result .pms-d-info-block li,#substance-matrix-app .pms-e-result .pms-d-help p{font-size:.9rem;line-height:1.58}#substance-matrix-app .pms-e-result-visuals{grid-column:2;grid-row:1 / 3;gap:4px}#substance-matrix-app .pms-e-result-visuals>span{width:54px;height:54px}#substance-matrix-app .pms-e-empty{padding:18px;text-align:center}#substance-matrix-app .pms-e-substance-sheet{gap:16px;margin-top:24px}#substance-matrix-app .pms-e-substance-header{display:grid;grid-template-columns:minmax(0,1fr) 78px;min-height:0;align-items:start;gap:14px;padding:22px 20px;border-radius:18px}#substance-matrix-app .pms-e-substance-heading{display:contents}#substance-matrix-app .pms-e-substance-heading h2{grid-column:1;grid-row:1;align-self:center;font-size:1.7rem}#substance-matrix-app .pms-e-substance-nav{grid-column:1 / -1;grid-row:2;gap:7px}#substance-matrix-app .pms-e-substance-nav a{min-height:34px;padding:6px 11px;font-size:.76rem}#substance-matrix-app .pms-e-substance-visual{grid-column:2;grid-row:1;width:78px;height:78px;flex-basis:78px}#substance-matrix-app .pms-e-substance-sections{gap:14px}#substance-matrix-app .pms-e-substance-section{padding:22px 20px;border-radius:17px}#substance-matrix-app .pms-e-substance-section h3{margin-bottom:12px;font-size:1.08rem}#substance-matrix-app .pms-e-substance-section p,#substance-matrix-app .pms-e-substance-section li{font-size:.9rem;line-height:1.58}#substance-matrix-app .pms-e-substance-timeline{margin-top:18px}#substance-matrix-app .pms-e-timeline-step strong{font-size:.86rem}#substance-matrix-app .pms-e-substance-disclaimer{padding:19px 20px;border-radius:17px}}@media(prefers-reduced-motion:reduce){#substance-matrix-app .pms-e-result.has-animated-risk-border .pms-e-result-lead:after{opacity:1;animation:none}}#substance-matrix-app .pms-shell-reference{--pms-reference-blue: #064ee8;--pms-reference-blue-dark: #0039bd;--pms-reference-pale: #eaf1ff;--pms-reference-lilac: #f0ecff;background:linear-gradient(128deg,#ffcc6373,#fff0 27%),linear-gradient(224deg,#064ee8b8,#997dff80 25%,#fff0 52%),#fff}#substance-matrix-app .pms-reference-view{width:min(calc(100% - 48px),1040px);margin:0 auto;padding:46px 0 76px;scroll-margin-top:var(--pms-reference-scroll-offset, 16px)}#substance-matrix-app .pms-reference-header{display:grid;width:min(100%,960px);gap:12px;max-width:none;margin:0 auto 32px}#substance-matrix-app .pms-reference-header h1,#substance-matrix-app .pms-reference-sheet-header h1,#substance-matrix-app .pms-reference-diagnostics h1{margin:0;color:#10233f;font-size:2.35rem;font-weight:900;line-height:1.06}#substance-matrix-app .pms-reference-header h1{line-height:1.2;text-wrap:balance}#substance-matrix-app .pms-shell-reference #pms-title:focus{outline:none}#substance-matrix-app .pms-reference-header p{max-width:70ch;margin:0;color:#556174;font-size:1rem;font-weight:500;line-height:1.55}#substance-matrix-app .pms-reference-directory{display:grid;width:min(100%,960px);grid-template-columns:minmax(0,.88fr) minmax(0,1.12fr);gap:32px;align-items:stretch;margin-inline:auto}#substance-matrix-app .pms-reference-directory-column{display:grid;min-width:0;grid-template-rows:auto minmax(0,1fr);gap:16px}#substance-matrix-app .pms-reference-directory-column h2,#substance-matrix-app .pms-reference-related h2{margin:0;color:#10233f;font-size:1.25rem;font-weight:900;line-height:1.3}#substance-matrix-app .pms-reference-substance-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));grid-auto-rows:1fr;gap:12px}#substance-matrix-app .pms-reference-substance-card,#substance-matrix-app .pms-reference-interaction-card{position:relative;display:grid;width:100%;min-width:0;cursor:pointer;gap:12px;color:var(--pms-reference-blue);border:1.5px solid rgba(6,78,232,.18);border-radius:18px;background:#fff;box-shadow:0 3px 12px #064ee80f;text-align:left;touch-action:manipulation;transition:background-color .16s ease,border-color .16s ease,box-shadow .16s ease,transform .16s ease}#substance-matrix-app .pms-reference-substance-card:focus-visible,#substance-matrix-app .pms-reference-interaction-card:focus-visible{border-color:var(--pms-reference-blue);background:var(--pms-reference-pale)}@media(hover:hover)and (pointer:fine){#substance-matrix-app .pms-reference-substance-card:hover,#substance-matrix-app .pms-reference-interaction-card:hover{border-color:var(--pms-reference-blue);background:#f4f7ff;box-shadow:0 8px 20px #064ee81f;transform:translateY(-2px)}}#substance-matrix-app .pms-reference-substance-card:active,#substance-matrix-app .pms-reference-interaction-card:active{background:var(--pms-reference-pale);box-shadow:none;transform:translateY(0)}#substance-matrix-app .pms-reference-substance-card{min-height:136px;grid-template-rows:72px auto;align-content:center;justify-items:center;padding:12px 16px;text-align:center}#substance-matrix-app .pms-reference-substance-card img{width:72px;height:72px;object-fit:contain}#substance-matrix-app .pms-reference-sheet-header span{color:#5573a6;font-size:.75rem;font-weight:850;line-height:1;text-transform:uppercase}#substance-matrix-app .pms-reference-substance-card strong,#substance-matrix-app .pms-reference-combo-item>span{min-width:0;max-width:100%;overflow-wrap:anywhere;font-size:1.0625rem;font-weight:600;line-height:1.4;text-wrap:pretty}#substance-matrix-app .pms-reference-interaction-list{display:grid;gap:12px}#substance-matrix-app .pms-reference-directory .pms-reference-interaction-list{grid-auto-rows:minmax(0,1fr)}#substance-matrix-app .pms-reference-directory .pms-reference-interaction-card{min-height:0;padding:4px 18px}#substance-matrix-app .pms-reference-directory .pms-reference-combo-visual{width:min(100%,380px);grid-template-columns:minmax(0,1fr) 20px minmax(0,1fr)}#substance-matrix-app .pms-reference-directory .pms-reference-combo-item{grid-template-rows:52px auto;gap:3px}#substance-matrix-app .pms-reference-directory .pms-reference-combo-item img{width:52px;height:52px}#substance-matrix-app .pms-reference-directory .pms-reference-combo-visual i{display:grid;height:52px;margin-top:0;place-items:center;color:#5561749e;font-size:1.1rem;font-weight:600;transform:translateY(12px)}#substance-matrix-app .pms-reference-interaction-card{min-height:132px;place-items:center;padding:14px 18px;text-align:center}#substance-matrix-app .pms-reference-combo-visual{display:grid;width:min(100%,300px);grid-template-columns:minmax(0,1fr) 16px minmax(0,1fr);gap:10px;align-items:start;text-align:center}#substance-matrix-app .pms-reference-combo-item{display:grid;min-width:0;grid-template-rows:64px auto;gap:8px;justify-items:center}#substance-matrix-app .pms-reference-combo-item img{width:64px;height:64px;object-fit:contain}#substance-matrix-app .pms-reference-combo-visual i{margin-top:22px;color:#5561749e;font-style:normal;font-size:1rem;font-weight:600;line-height:1}#substance-matrix-app .pms-reference-diagnostics{display:grid;gap:16px;max-width:760px;padding:24px;border:1px solid #dce5f2;border-radius:8px;background:#fff;box-shadow:0 10px 28px #1e385b14}#substance-matrix-app .pms-reference-diagnostics h2{margin:0;color:#10233f;font-size:1.25rem;font-weight:900}#substance-matrix-app .pms-reference-diagnostics p,#substance-matrix-app .pms-reference-diagnostics li{margin:0;color:#556174;font-size:.98rem;line-height:1.55}#substance-matrix-app .pms-reference-diagnostics ul{display:grid;gap:10px;margin:0;padding:0;list-style:none}#substance-matrix-app .pms-reference-diagnostics li{display:grid;gap:4px;padding-top:10px;border-top:1px solid #edf1f7}#substance-matrix-app .pms-reference-diagnostics li strong{color:#10233f}#substance-matrix-app .pms-reference-diagnostics-actions{display:flex;flex-wrap:wrap;gap:10px;padding-top:4px}#substance-matrix-app .pms-reference-diagnostics-actions button{min-height:42px;cursor:pointer;padding:9px 14px;color:#174ea6;border:1px solid #b8caeb;border-radius:999px;background:#fff;font-size:.88rem;font-weight:850}#substance-matrix-app .pms-reference-diagnostics-actions button:hover,#substance-matrix-app .pms-reference-diagnostics-actions button:focus-visible{border-color:#174ea6;outline:none}#substance-matrix-app .pms-reference-sheet{display:grid;gap:28px;max-width:760px;margin:0 auto}#substance-matrix-app .pms-reference-back{display:inline-flex;width:fit-content;min-height:44px;cursor:pointer;align-items:center;justify-content:center;padding:8px 14px;color:#5573a6;border:1px solid currentColor;border-radius:999px;background:transparent;font-size:.86rem;font-weight:800;line-height:1.2;transition:color .15s ease,background-color .15s ease,box-shadow .15s ease}#substance-matrix-app .pms-reference-back svg{width:18px;height:18px;flex:0 0 18px}#substance-matrix-app .pms-reference-back:hover,#substance-matrix-app .pms-reference-back:focus-visible{color:var(--pms-reference-blue);border-color:var(--pms-reference-blue);outline:none;background:#ffffff6b;box-shadow:0 4px 12px #064ee81f}#substance-matrix-app .pms-reference-back.is-bottom{margin-top:4px}#substance-matrix-app .pms-reference-sheet-header{display:grid;min-height:0;grid-template-columns:minmax(0,1fr) 72px;grid-template-areas:"heading visual" "takeaway takeaway" "nav nav";align-items:center;gap:12px 14px;padding:18px 24px;border-radius:24px;background:#fffffff5;box-shadow:0 14px 34px #064ee824}#substance-matrix-app .pms-reference-sheet-header>img{grid-area:visual;width:60px;height:60px;margin-right:12px;justify-self:end;flex:0 0 60px;object-fit:contain}#substance-matrix-app .pms-reference-sheet-header>.pms-reference-substance-heading{grid-area:heading;display:grid;min-width:0;gap:14px}#substance-matrix-app .pms-reference-sheet-header h1,#substance-matrix-app .pms-shell-reference .pms-reference-interaction-header h1{color:var(--pms-reference-blue);font-size:2.2rem;font-weight:800;line-height:1.08}#substance-matrix-app .pms-reference-sheet-nav{grid-area:nav;display:flex;flex-wrap:wrap;gap:6px;padding-top:12px;border-top:1px solid rgba(6,78,232,.12)}#substance-matrix-app .pms-reference-sheet-nav a{display:inline-flex;min-height:32px;align-items:center;justify-content:center;padding:5px 11px;color:var(--pms-reference-blue);border:1px solid #d5e1ff;border-radius:999px;background:#f2f6ff;font-size:.8rem;font-weight:650;line-height:1;text-decoration:none;transition:color .15s ease,background-color .15s ease,box-shadow .15s ease}#substance-matrix-app .pms-reference-sheet-nav a:is(:hover,:focus-visible){color:#fff;outline:none;background:var(--pms-reference-blue);box-shadow:0 5px 12px #064ee833}#substance-matrix-app .pms-reference-sheet-header .pms-reference-header-takeaway{grid-template-columns:minmax(0,1fr);gap:4px;padding-top:0;border-top:0}#substance-matrix-app .pms-reference-sheet-header .pms-reference-header-takeaway-label{text-transform:none;font-size:.8rem;font-weight:650;line-height:1.4}#substance-matrix-app .pms-reference-sheet-header .pms-reference-header-takeaway-content :is(p,ul){font-size:.95rem;line-height:1.5}#substance-matrix-app .pms-shell-reference.pms-reference-is-interaction{--pms-reference-risk-ink: #475467;--pms-reference-risk-soft: #f2f4f7;background:linear-gradient(180deg,#f6f8fd00,#f6f8fd),linear-gradient(128deg,#ffcc634d,#ffcc6300 42%),linear-gradient(224deg,#064ee852,#997dff3d 30%,#997dff00 65%),#f6f8fd;background-size:100% 640px;background-repeat:no-repeat}#substance-matrix-app .pms-reference-is-interaction.pms-risk-theme-1{--pms-reference-risk-ink: #166549;--pms-reference-risk-soft: #edf8f2}#substance-matrix-app .pms-reference-is-interaction.pms-risk-theme-2{--pms-reference-risk-ink: #854d0e;--pms-reference-risk-soft: #fffbeb}#substance-matrix-app .pms-reference-is-interaction.pms-risk-theme-3{--pms-reference-risk-ink: #b42332;--pms-reference-risk-soft: #fff0f1}#substance-matrix-app .pms-reference-is-interaction.pms-risk-theme-4{--pms-reference-risk-ink: #9f1239;--pms-reference-risk-soft: #fff1f2}#substance-matrix-app .pms-reference-interaction-header{position:relative;display:grid;min-height:0;grid-template-columns:minmax(0,1fr) auto;grid-template-areas:"heading visual" "takeaway takeaway" "nav nav";align-items:center;gap:14px 24px;padding:24px 28px;border-radius:24px;background:#fffffff5;box-shadow:0 14px 34px #064ee824}#substance-matrix-app .pms-reference-association{grid-area:visual;display:grid;grid-template-columns:repeat(2,72px);gap:8px;align-items:center}#substance-matrix-app .pms-reference-association img{display:block;width:72px;height:72px;object-fit:contain}#substance-matrix-app .pms-reference-interaction-heading{grid-area:heading;display:grid;min-width:0;gap:8px}#substance-matrix-app .pms-reference-interaction-header .pms-reference-header-takeaway{gap:12px;padding-top:12px;border-top:0}#substance-matrix-app .pms-reference-interaction-meta{display:flex;flex-wrap:wrap;align-items:center;gap:8px 12px;margin:0 0 10px;color:#536174;font-size:.8125rem;font-weight:500;line-height:1.5}#substance-matrix-app .pms-reference-interaction-meta span{padding-left:12px;border-left:1px solid #d2dae5}#substance-matrix-app .pms-shell-reference .pms-reference-interaction-header h1{margin:0;text-wrap:balance}#substance-matrix-app .pms-reference-risk{display:inline-flex;width:fit-content;min-width:0;align-items:center;gap:7px;padding:7px 10px;color:var(--pms-reference-risk-ink);border:0;border-radius:6px;background:var(--pms-reference-risk-soft)}#substance-matrix-app .pms-reference-risk>svg{width:17px;height:17px;flex:0 0 17px}#substance-matrix-app .pms-reference-risk strong{font-size:.82rem;font-weight:700;line-height:1.35;overflow-wrap:anywhere}#substance-matrix-app .pms-reference-header-takeaway{grid-area:takeaway;display:grid;width:100%;max-width:none;grid-template-columns:auto minmax(0,1fr);align-items:start;gap:16px;padding-top:18px;border-top:1px solid rgba(6,78,232,.14)}#substance-matrix-app .pms-reference-header-takeaway-label{display:inline-flex;align-items:center;gap:7px;color:var(--pms-reference-blue);font-size:.82rem;font-weight:700;line-height:1.6}#substance-matrix-app .pms-reference-header-takeaway-label svg{width:16px;height:16px}#substance-matrix-app .pms-reference-header-takeaway-content :is(p,ul){margin:0;color:#555d70;font-size:1rem;font-weight:400;line-height:1.6}#substance-matrix-app .pms-reference-sections{display:grid;gap:20px}#substance-matrix-app .pms-reference-section{min-width:0;padding:28px 32px;scroll-margin-top:24px;border:0;border-radius:22px;background:#fff;box-shadow:0 10px 28px #064ee81c}#substance-matrix-app .pms-reference-section h2,#substance-matrix-app .pms-reference-section summary{margin:0 0 12px;color:#10233f;font-size:1.18rem;font-weight:900;line-height:1.25}#substance-matrix-app .pms-reference-section h2{display:flex;align-items:center;gap:12px}#substance-matrix-app .pms-reference-section-title-icon{display:inline-grid;width:30px;height:30px;flex:0 0 30px;place-items:center;color:var(--pms-reference-blue);border-radius:9px;background:var(--pms-reference-pale)}#substance-matrix-app .pms-reference-section-title-icon svg{width:17px;height:17px}#substance-matrix-app .pms-reference-section-title-label{min-width:0}#substance-matrix-app .pms-reference-section.is-risques .pms-reference-section-title-icon{color:#b54708;background:#fff1e7}#substance-matrix-app .pms-reference-section.is-risques>h2{margin-bottom:4px}#substance-matrix-app .pms-reference-risk-layout{display:grid;gap:18px;margin-top:0}#substance-matrix-app .pms-reference-risk-substances{display:grid;grid-template-columns:repeat(2,minmax(0,1fr))}#substance-matrix-app .pms-reference-risk-substance{min-width:0;padding:0 24px 20px 0}#substance-matrix-app .pms-reference-risk-substance+.pms-reference-risk-substance{padding-right:0;padding-left:24px;border-left:1px solid #dce6f6}#substance-matrix-app .pms-reference-risk-substance h3,#substance-matrix-app .pms-reference-risk-combination h3{display:flex;align-items:center;gap:10px;margin:0 0 12px;color:#10233f;font-size:1rem;font-weight:850}#substance-matrix-app .pms-reference-risk-substance h3 img{width:40px;height:40px;flex:0 0 40px;object-fit:contain}#substance-matrix-app .pms-reference-risk-combination{padding:16px 18px;border:0;border-radius:10px;background:#fff4ee}#substance-matrix-app .pms-reference-risk-combination-icon{display:inline-grid;width:30px;height:30px;flex:0 0 30px;place-items:center;border-radius:8px;background:#ffe3d6}#substance-matrix-app .pms-reference-risk-combination-icon svg{width:17px;height:17px}#substance-matrix-app .pms-reference-section p,#substance-matrix-app .pms-reference-section li{color:#404c5f;font-size:1rem;line-height:1.65}#substance-matrix-app .pms-reference-section p{margin:0}#substance-matrix-app .pms-reference-section p+p,#substance-matrix-app .pms-reference-section ul+p,#substance-matrix-app .pms-reference-section p+ul{margin-top:12px}#substance-matrix-app .pms-reference-section ul{display:grid;gap:8px;margin:0;padding-left:22px}#substance-matrix-app .pms-reference-section h3{margin:18px 0 8px;color:#24364f;font-size:1rem;font-weight:900;line-height:1.3}#substance-matrix-app .pms-reference-timeline{margin-top:22px;padding-top:18px;border-top:1px solid #e2e8f2}#substance-matrix-app .pms-reference-timeline h3{display:flex;align-items:center;gap:9px;margin:0 0 16px;color:var(--pms-reference-blue);font-size:.9375rem;font-weight:700}#substance-matrix-app .pms-reference-timeline h3 svg{box-sizing:content-box;width:16px;height:16px;padding:5px;color:#4f6fe8;border-radius:8px;background:#eef2ff}#substance-matrix-app .pms-reference-timing-facts{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:20px;margin:16px 0 0}#substance-matrix-app .pms-reference-timing-facts>div{padding-left:12px;border-left:3px solid #adcfff}#substance-matrix-app .pms-reference-timing-facts dt{color:#41628f;font-size:.875rem;line-height:1.5}#substance-matrix-app .pms-reference-timing-facts dd{margin:4px 0 0;color:#0c2a48;font-size:1rem;font-weight:650;line-height:1.5}#substance-matrix-app .pms-reference-timeline .pms-reference-timing-mode,#substance-matrix-app .pms-reference-timeline .pms-reference-timing-alternative{margin:12px 0 0;font-size:.9375rem;line-height:1.55}#substance-matrix-app .pms-reference-timing-alternative{padding:10px 12px;border-left:3px solid #adcfff;background:#f0f6ff}#substance-matrix-app .pms-reference-timeline ol{--pms-reference-timeline-columns: 3;position:relative;display:grid;grid-template-columns:repeat(var(--pms-reference-timeline-columns),minmax(0,1fr));margin:18px 0 0;padding:0;list-style:none}#substance-matrix-app .pms-reference-timeline ol:before{position:absolute;top:25px;right:calc(50% / var(--pms-reference-timeline-columns));left:calc(50% / var(--pms-reference-timeline-columns));height:4px;content:"";border-radius:999px;background:linear-gradient(to right,#80baf2,#5875e8,#5875e8)}#substance-matrix-app .pms-reference-timeline li{position:relative;z-index:1;display:grid;grid-template-rows:12px 20px auto;gap:5px;min-width:0;justify-items:center;padding:0 8px;text-align:center}#substance-matrix-app .pms-reference-timeline li span{color:#68758c;font-size:.6875rem;font-weight:700;line-height:1;text-transform:uppercase}#substance-matrix-app .pms-reference-timeline li i{display:block;box-sizing:border-box;width:16px;height:16px;align-self:center;border:3px solid #ffffff;border-radius:50%;background:#5875e8;box-shadow:0 0 0 2px #5875e8}#substance-matrix-app .pms-reference-timeline li:first-child i{background:#80baf2;box-shadow:0 0 0 2px #80baf2}#substance-matrix-app .pms-reference-timeline li i.is-start{position:relative;display:grid;place-items:center;color:#80baf2;border:0;border-radius:0;background:transparent;box-shadow:none}#substance-matrix-app .pms-reference-timeline li i.is-start svg{position:absolute;top:50%;left:50%;width:24px;height:24px;transform:translate(-50%,-50%);stroke-width:4}#substance-matrix-app .pms-reference-timeline li strong{margin:0;color:#24364f;font-size:.8125rem;font-weight:700;line-height:1.35;text-wrap:pretty}#substance-matrix-app .pms-reference-section.is-help{border:1px solid #bcd5d2;background:#eef8f6}#substance-matrix-app .pms-reference-section.is-more{padding-top:18px;padding-bottom:18px}#substance-matrix-app .pms-reference-section summary{display:flex;min-height:48px;cursor:pointer;align-items:center;justify-content:space-between;gap:16px;margin-bottom:0;list-style:none}#substance-matrix-app .pms-reference-section summary>.pms-reference-section-title-label{flex:1}#substance-matrix-app .pms-reference-section summary::-webkit-details-marker{display:none}#substance-matrix-app .pms-reference-more-toggle{display:grid;width:30px;height:30px;flex:0 0 30px;place-items:center;color:var(--pms-reference-blue);border:1px solid rgba(6,78,232,.2);border-radius:50%;background:#ffffffb8;transition:color .15s ease,background-color .15s ease,border-color .15s ease,transform .15s ease}#substance-matrix-app .pms-reference-more-toggle svg{width:18px;height:18px}#substance-matrix-app .pms-reference-section.is-more[open] .pms-reference-more-toggle{color:#fff;border-color:var(--pms-reference-blue);background:var(--pms-reference-blue);transform:rotate(180deg)}#substance-matrix-app .pms-reference-more-content{padding-top:12px}#substance-matrix-app .pms-reference-editorial-figure{width:100%;margin:18px 0 2px}#substance-matrix-app .pms-reference-editorial-figure img{display:block;width:100%;height:auto;max-height:520px;object-fit:contain;border:1px solid rgba(33,70,136,.12);border-radius:12px;background:#eef5f9}#substance-matrix-app .pms-reference-related{display:grid;gap:12px;padding-top:24px}#substance-matrix-app .pms-reference-related .pms-reference-substance-grid{grid-template-columns:repeat(2,minmax(0,180px));justify-content:start;gap:12px}#substance-matrix-app .pms-reference-related .pms-reference-substance-card{min-height:92px;grid-template-rows:36px auto;gap:8px;padding:12px 14px}#substance-matrix-app .pms-reference-related .pms-reference-substance-card img{width:36px;height:36px}#substance-matrix-app .pms-reference-related .pms-reference-interaction-list{width:100%;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px}#substance-matrix-app .pms-reference-related .pms-reference-interaction-card{min-height:108px;padding:12px 10px}#substance-matrix-app .pms-reference-related .pms-reference-combo-visual{width:100%;grid-template-columns:minmax(0,1fr) 12px minmax(0,1fr);gap:4px}#substance-matrix-app .pms-reference-related .pms-reference-combo-item{grid-template-rows:44px auto;gap:6px}#substance-matrix-app .pms-reference-related .pms-reference-combo-item img{width:44px;height:44px}#substance-matrix-app .pms-reference-related .pms-reference-combo-visual i{display:grid;height:44px;margin-top:0;place-items:center}#substance-matrix-app .pms-reference-related :is(.pms-reference-substance-card strong,.pms-reference-combo-item>span){font-size:.9rem}#substance-matrix-app .pms-shell-reference :is(h1,h2,h3){color:var(--pms-reference-blue);font-weight:800;overflow-wrap:anywhere}#substance-matrix-app .pms-reference-header p,#substance-matrix-app .pms-reference-section p,#substance-matrix-app .pms-reference-section li{color:#555d70}#substance-matrix-app .pms-reference-directory-column h2,#substance-matrix-app .pms-reference-related h2,#substance-matrix-app .pms-reference-section h2{font-weight:700}#substance-matrix-app .pms-reference-sheet-header span,#substance-matrix-app .pms-reference-combo-visual i{color:var(--pms-reference-blue)}#substance-matrix-app .pms-reference-back{min-height:44px;color:var(--pms-reference-blue)}#substance-matrix-app .pms-reference-section summary{color:var(--pms-reference-blue);font-weight:700}#substance-matrix-app .pms-reference-section.is-help{border-color:#064ee833;background:var(--pms-reference-pale)}#substance-matrix-app .pms-reference-diagnostics-actions button{min-height:44px;color:var(--pms-reference-blue);border:1.5px solid rgba(6,78,232,.2);box-shadow:0 4px 10px #064ee814;font-weight:700}#substance-matrix-app .pms-reference-diagnostics-actions button:is(:hover,:focus-visible){color:#fff;border-color:var(--pms-reference-blue);background:var(--pms-reference-blue)}#substance-matrix-app .pms-shell-reference :is(button,summary):focus-visible{outline:3px solid var(--pms-reference-blue-dark);outline-offset:4px}@media(prefers-reduced-motion:reduce){#substance-matrix-app .pms-reference-substance-card,#substance-matrix-app .pms-reference-interaction-card{transition:none;transform:none}#substance-matrix-app .pms-reference-more-toggle{transition:none}}@media(max-width:900px){#substance-matrix-app .pms-reference-related .pms-reference-interaction-list{grid-template-columns:repeat(2,minmax(0,1fr))}}@media(max-width:700px){#substance-matrix-app .pms-reference-view{width:min(calc(100% - 28px),1040px);padding:46px 0 58px}#substance-matrix-app .pms-reference-header h1,#substance-matrix-app .pms-reference-sheet-header h1,#substance-matrix-app .pms-reference-diagnostics h1{font-size:1.9rem}#substance-matrix-app .pms-reference-header h1{font-size:1.75rem}#substance-matrix-app .pms-reference-directory{grid-template-columns:1fr;gap:28px}#substance-matrix-app .pms-reference-directory .pms-reference-interaction-card{min-height:86px;padding:4px 12px}#substance-matrix-app .pms-reference-directory .pms-reference-combo-item{grid-template-rows:48px auto;gap:3px}#substance-matrix-app .pms-reference-directory .pms-reference-combo-item img{width:48px;height:48px}#substance-matrix-app .pms-reference-directory .pms-reference-combo-visual i{height:48px;margin-top:0}#substance-matrix-app .pms-reference-substance-grid{grid-template-columns:repeat(2,minmax(0,1fr));gap:12px}#substance-matrix-app .pms-reference-substance-card{min-height:112px;grid-template-rows:52px auto;gap:6px;padding:10px 12px}#substance-matrix-app .pms-reference-substance-card img{width:52px;height:52px}#substance-matrix-app .pms-reference-interaction-card{min-height:120px;padding:12px 14px}#substance-matrix-app .pms-reference-related .pms-reference-interaction-list{grid-template-columns:minmax(0,1fr)}#substance-matrix-app .pms-reference-related .pms-reference-interaction-card{min-height:108px;padding:12px 10px}#substance-matrix-app .pms-reference-related .pms-reference-combo-visual{width:min(100%,240px);grid-template-columns:minmax(0,1fr) 12px minmax(0,1fr);gap:4px}#substance-matrix-app .pms-reference-related .pms-reference-combo-item{grid-template-rows:44px auto;gap:6px}#substance-matrix-app .pms-reference-related .pms-reference-combo-item img{width:44px;height:44px}#substance-matrix-app .pms-reference-related .pms-reference-combo-visual i{height:44px;margin-top:0}#substance-matrix-app .pms-reference-combo-visual{width:min(100%,280px);grid-template-columns:minmax(0,1fr) 14px minmax(0,1fr);gap:8px}#substance-matrix-app .pms-reference-combo-item{grid-template-rows:54px auto;gap:7px}#substance-matrix-app .pms-reference-combo-item img{width:54px;height:54px}#substance-matrix-app .pms-reference-combo-visual i{margin-top:18px}#substance-matrix-app .pms-reference-sheet{gap:24px}#substance-matrix-app .pms-reference-sections{gap:14px}#substance-matrix-app .pms-reference-section{padding:22px 20px;border-radius:17px}#substance-matrix-app .pms-reference-risk-substances{grid-template-columns:minmax(0,1fr)}#substance-matrix-app .pms-reference-risk-substance,#substance-matrix-app .pms-reference-risk-substance+.pms-reference-risk-substance{padding:4px 0 18px;border-left:0}#substance-matrix-app .pms-reference-risk-substance+.pms-reference-risk-substance{border-top:1px solid #dce6f6}#substance-matrix-app .pms-reference-risk-combination{padding:16px}#substance-matrix-app .pms-reference-sheet-header{display:grid;min-height:0;grid-template-columns:minmax(0,1fr) 58px;align-items:flex-start;gap:10px;padding:16px;border-radius:18px}#substance-matrix-app .pms-reference-sheet-header>.pms-reference-substance-heading{display:contents}#substance-matrix-app .pms-reference-sheet-header h1{grid-column:1;grid-row:1;align-self:center;font-size:1.7rem}#substance-matrix-app .pms-reference-sheet-header>img{grid-column:2;grid-row:1;width:52px;height:52px;margin-right:6px;flex-basis:52px}#substance-matrix-app .pms-reference-sheet-header .pms-reference-header-takeaway{grid-column:1 / -1;grid-row:2}#substance-matrix-app .pms-reference-sheet-nav{gap:5px}#substance-matrix-app .pms-reference-sheet-nav a{min-height:30px;padding:4px 9px;font-size:.74rem}#substance-matrix-app .pms-reference-interaction-header{min-height:0;grid-template-columns:minmax(0,1fr) 112px;grid-template-areas:none;align-items:start;gap:12px;padding:22px 20px;border-radius:18px}#substance-matrix-app .pms-reference-interaction-heading{display:contents}#substance-matrix-app .pms-reference-association{grid-column:2;grid-row:2;grid-template-columns:repeat(2,54px);gap:4px;justify-content:end}#substance-matrix-app .pms-reference-association img{width:54px;height:54px}#substance-matrix-app .pms-reference-interaction-header .pms-reference-risk{grid-column:1;grid-row:2;align-self:center}#substance-matrix-app .pms-reference-interaction-header .pms-reference-header-takeaway{grid-column:1 / -1;grid-row:3}#substance-matrix-app .pms-reference-interaction-header .pms-reference-sheet-nav{grid-column:1 / -1;grid-row:4}#substance-matrix-app .pms-shell-reference .pms-reference-interaction-header h1{grid-column:1 / -1;grid-row:1;font-size:1.7rem}#substance-matrix-app .pms-reference-header-takeaway-content :is(p,ul){font-size:1rem;line-height:1.62}#substance-matrix-app .pms-reference-section p,#substance-matrix-app .pms-reference-section li{font-size:1.0625rem;line-height:1.65}#substance-matrix-app .pms-reference-header-takeaway{grid-template-columns:minmax(0,1fr);gap:5px;padding-top:14px}#substance-matrix-app .pms-reference-timeline{overflow:visible;padding:16px 0 0}#substance-matrix-app .pms-reference-timeline ol{display:grid;width:100%;grid-template-columns:minmax(0,1fr);gap:0;margin-top:14px}#substance-matrix-app .pms-reference-timeline ol:before{display:none}#substance-matrix-app .pms-reference-timeline li{grid-template-columns:22px minmax(0,1fr);grid-template-rows:auto auto;gap:3px 12px;justify-items:start;padding:0 0 18px;text-align:left}#substance-matrix-app .pms-reference-timeline li:not(:last-child):after{position:absolute;z-index:-1;top:8px;bottom:-8px;left:9px;width:4px;content:"";border-radius:999px;background:#5875e8}#substance-matrix-app .pms-reference-timeline li span{grid-column:2;grid-row:1}#substance-matrix-app .pms-reference-timeline li i{grid-column:1;grid-row:1 / 3;align-self:start;justify-self:center}#substance-matrix-app .pms-reference-timeline li strong{grid-column:2;grid-row:2}#substance-matrix-app .pms-reference-timeline li i.is-start svg{transform:translate(-50%,-50%) rotate(90deg)}#substance-matrix-app .pms-reference-timeline li:first-child:after{background:linear-gradient(to bottom,#80baf2,#5875e8)}#substance-matrix-app .pms-reference-timeline li:last-child{padding-bottom:0}}@media(max-width:360px){#substance-matrix-app .pms-reference-substance-card{padding:12px 10px}#substance-matrix-app .pms-reference-substance-card strong,#substance-matrix-app .pms-reference-combo-item>span{font-size:1rem}#substance-matrix-app .pms-reference-interaction-card{padding:12px}#substance-matrix-app .pms-reference-combo-visual{grid-template-columns:minmax(0,1fr) 12px minmax(0,1fr)}}#substance-matrix-app .pms-shell-reference{--pms-reference-scroll-offset: 16px}#substance-matrix-app .pms-reference-header{gap:14px;margin-bottom:36px}#substance-matrix-app .pms-reference-header h1{color:#10233f;font-weight:700;letter-spacing:-.025em}#substance-matrix-app .pms-reference-header p{color:#475870;font-weight:450;line-height:1.65}#substance-matrix-app .pms-reference-directory-column h2,#substance-matrix-app .pms-reference-related h2{font-weight:700}#substance-matrix-app .pms-reference-substance-card,#substance-matrix-app .pms-reference-interaction-card,#substance-matrix-app .pms-reference-back{text-decoration:none}#substance-matrix-app .pms-reference-hero{display:grid;grid-template-columns:auto minmax(0,1fr);grid-template-areas:"media identity";align-items:center;gap:20px;padding:4px 0 8px;border:0;border-radius:0;background:transparent;box-shadow:none}#substance-matrix-app .pms-reference-hero-media{grid-area:media;display:grid;min-width:0;place-items:center}#substance-matrix-app .pms-reference-substance-hero .pms-reference-hero-media img{display:block;width:76px;height:76px;object-fit:contain}#substance-matrix-app .pms-reference-hero-identity{grid-area:identity;display:grid;min-width:0;gap:10px}#substance-matrix-app .pms-reference-hero h1{margin:0;color:var(--pms-reference-blue);font-size:clamp(2rem,5vw,2.7rem);font-weight:700;letter-spacing:-.025em;line-height:1.08;text-wrap:balance}#substance-matrix-app .pms-reference-hero .pms-reference-association{grid-area:media;grid-template-columns:repeat(2,72px)}#substance-matrix-app .pms-reference-sheet-nav{grid-area:auto;position:static;z-index:2;display:flex;flex-wrap:nowrap;gap:2px;overflow-x:auto;overscroll-behavior-x:contain;padding:8px 0;border:0;background:#fffffff0;box-shadow:inset 0 -1px #064ee824;scrollbar-width:thin}#substance-matrix-app .pms-reference-sheet-nav a{flex:0 0 auto;min-height:44px;padding:10px 12px 8px;color:#536174;border:0;border-bottom:3px solid transparent;border-radius:8px 8px 0 0;background:transparent;font-size:.86rem;font-weight:600;line-height:1.2}#substance-matrix-app .pms-reference-sheet-nav a.is-active{color:var(--pms-reference-blue);border-bottom-color:var(--pms-reference-blue);background:var(--pms-reference-pale);font-weight:700}#substance-matrix-app .pms-reference-sheet-nav a:is(:hover,:focus-visible){color:var(--pms-reference-blue);outline:3px solid var(--pms-reference-blue-dark);outline-offset:-3px;background:var(--pms-reference-pale);box-shadow:none}#substance-matrix-app .pms-reference-section{scroll-margin-top:var(--pms-reference-scroll-offset)}#substance-matrix-app .pms-reference-section>h2,#substance-matrix-app .pms-reference-section>summary{scroll-margin-top:var(--pms-reference-scroll-offset)}#substance-matrix-app .pms-reference-section.is-takeaway{border:1px solid rgba(6,78,232,.12);background:linear-gradient(135deg,#fff,#f3f7ff);box-shadow:0 8px 22px #064ee814}#substance-matrix-app .pms-reference-section.is-takeaway h2{color:var(--pms-reference-blue)}#substance-matrix-app .pms-reference-content-link{color:var(--pms-reference-blue-dark);font-weight:650;text-decoration-line:underline;text-decoration-thickness:1.5px;text-underline-offset:.16em}#substance-matrix-app .pms-reference-content-link:focus-visible{outline:3px solid var(--pms-reference-blue-dark);outline-offset:3px}#substance-matrix-app .pms-reference-phone-link{position:relative;display:inline-flex;min-height:34px;align-items:center;gap:8px;margin:0 2px;padding:5px 10px;color:#315d8a;border:1px solid #b9cfe7;border-radius:12px;background:#e5f0fb;box-shadow:0 2px 6px #21468814;font-size:.875rem;font-weight:600;line-height:1;text-decoration:none;vertical-align:middle;transition:color .14s ease,border-color .14s ease,background-color .14s ease,box-shadow .14s ease}#substance-matrix-app .pms-reference-phone-link:before{position:absolute;top:-5px;right:0;bottom:-5px;left:0;content:""}#substance-matrix-app .pms-reference-phone-link:is(:hover,:focus-visible){color:#244c75;border-color:#91b2d4;background:#d9e9f8;box-shadow:0 3px 9px #2146881f}#substance-matrix-app .pms-reference-phone-link:focus-visible{outline:2px solid var(--pms-reference-blue-dark);outline-offset:2px}#substance-matrix-app .pms-reference-section.is-besoin-aide .pms-reference-help-phone{display:inline-flex;align-items:center;gap:7px;vertical-align:middle}#substance-matrix-app .pms-reference-help-phone-icon{flex:0 0 auto;font-size:1rem;line-height:1}#substance-matrix-app .pms-reference-help-phone-copy{min-width:0}#substance-matrix-app .pms-reference-section.is-besoin-aide .pms-reference-help-phone+.pms-reference-help-phone{margin-top:0;margin-left:16px;padding-left:18px;border-left:1px solid #bfd0e3}#substance-matrix-app .pms-reference-help-directory{display:grid;grid-template-columns:38px minmax(0,1fr) 20px;align-items:center;gap:12px;margin:14px 0 12px;padding:11px 13px;color:#244f76;border:1px solid #b9d8d7;border-radius:12px;background:#eaf6f5;box-shadow:0 3px 10px #2146880f;text-decoration:none;transition:color .14s ease,border-color .14s ease,background-color .14s ease,box-shadow .14s ease,transform .14s ease}#substance-matrix-app .pms-reference-help-directory-icon{display:grid;width:38px;height:38px;place-items:center;color:#397b79;border-radius:10px;background:#d9eeec}#substance-matrix-app .pms-reference-help-directory-icon svg,#substance-matrix-app .pms-reference-help-directory-action svg{width:18px;height:18px}#substance-matrix-app .pms-reference-help-directory-copy{display:grid;min-width:0;gap:2px}#substance-matrix-app .pms-reference-help-directory-copy strong{color:#214b70;font-size:.94rem;font-weight:700;line-height:1.3}#substance-matrix-app .pms-reference-help-directory-copy small{color:#63778d;font-size:.78rem;font-weight:550;line-height:1.25}#substance-matrix-app .pms-reference-help-directory-action{display:grid;place-items:center;color:#52807f}#substance-matrix-app .pms-reference-help-directory:is(:hover,:focus-visible){color:#1f476b;border-color:#91bfbd;background:#e1f1f0;box-shadow:0 5px 14px #2146881a;transform:translateY(-1px)}#substance-matrix-app .pms-reference-help-directory:focus-visible{outline:3px solid var(--pms-reference-blue-dark);outline-offset:3px}@media(max-width:760px){#substance-matrix-app .pms-reference-section.is-besoin-aide .pms-reference-help-phone{display:flex;width:100%}#substance-matrix-app .pms-reference-section.is-besoin-aide .pms-reference-help-phone+.pms-reference-help-phone{margin-top:8px;margin-left:0;padding-top:0;padding-left:0;border-top:0;border-left:0}}#substance-matrix-app .pms-reference-back:focus-visible,#substance-matrix-app .pms-reference-substance-card:focus-visible,#substance-matrix-app .pms-reference-interaction-card:focus-visible{outline:3px solid var(--pms-reference-blue-dark);outline-offset:3px}@media(max-width:700px){#substance-matrix-app .pms-reference-hero{grid-template-columns:minmax(0,1fr);grid-template-areas:"media" "identity";gap:12px;align-items:start}#substance-matrix-app .pms-reference-hero-media{justify-self:start}#substance-matrix-app .pms-reference-substance-hero .pms-reference-hero-media img{width:64px;height:64px}#substance-matrix-app .pms-reference-hero h1{font-size:1.9rem}#substance-matrix-app .pms-reference-hero .pms-reference-association{grid-template-columns:repeat(2,58px);gap:6px}#substance-matrix-app .pms-reference-hero .pms-reference-association img{width:58px;height:58px}#substance-matrix-app .pms-reference-sheet-nav{margin-inline:-2px;padding-inline:2px}#substance-matrix-app .pms-reference-sheet-nav a{min-height:44px;padding:10px 11px 8px;font-size:.8rem}#substance-matrix-app .pms-reference-section.is-takeaway{padding:20px}}#substance-matrix-app .pms-shell-reference{--pms-reference-surface: rgba(255, 255, 255, .94);--pms-reference-surface-lead: rgba(255, 255, 255, .82);--pms-reference-surface-help: #f5faff;--pms-reference-border: rgba(6, 78, 232, .14);--pms-reference-border-subtle: rgba(31, 65, 117, .1);--pms-reference-shadow-section: 0 4px 14px rgba(33, 70, 136, .07);--pms-reference-shadow-card: 0 3px 10px rgba(33, 70, 136, .06);--pms-reference-radius-section: 18px;--pms-reference-radius-lead: 16px;--pms-reference-radius-control: 8px;background:radial-gradient(72% 44% at 0% 0%,#ffcc635c,#fff0 72%),radial-gradient(76% 52% at 100% 0%,#064ee861,#997dff3d 42%,#fff0 76%),#f7f9fe}#substance-matrix-app .pms-reference-is-interaction.pms-risk-theme-1{--pms-reference-risk-border: #a7d9c6}#substance-matrix-app .pms-reference-is-interaction.pms-risk-theme-2{--pms-reference-risk-border: #f0d48d}#substance-matrix-app .pms-reference-is-interaction.pms-risk-theme-3{--pms-reference-risk-border: #f1bdc4}#substance-matrix-app .pms-reference-is-interaction.pms-risk-theme-4{--pms-reference-risk-border: #efbdcb}#substance-matrix-app .pms-reference-header h1,#substance-matrix-app .pms-reference-hero h1{font-weight:700}#substance-matrix-app .pms-reference-directory-column h2,#substance-matrix-app .pms-reference-related h2{color:#183c6d;font-weight:650}#substance-matrix-app .pms-reference-substance-card,#substance-matrix-app .pms-reference-interaction-card{border-color:var(--pms-reference-border);border-radius:16px;background:#fff;background:var(--pms-reference-surface);box-shadow:var(--pms-reference-shadow-card);transition:background-color .14s ease,border-color .14s ease,box-shadow .14s ease}@media(hover:hover)and (pointer:fine){#substance-matrix-app .pms-reference-substance-card:hover,#substance-matrix-app .pms-reference-interaction-card:hover{border-color:#064ee852;background:#fffffffa;box-shadow:0 5px 14px #21468817;transform:none}}#substance-matrix-app .pms-reference-substance-card:active,#substance-matrix-app .pms-reference-interaction-card:active{transform:none}#substance-matrix-app .pms-reference-combo-visual i{color:#8794a6}#substance-matrix-app .pms-reference-back{gap:4px;padding:8px 4px;color:#41628f;border:0;border-radius:var(--pms-reference-radius-control);background:transparent;font-weight:600;text-decoration:none}#substance-matrix-app .pms-reference-back:hover,#substance-matrix-app .pms-reference-back:focus-visible{color:var(--pms-reference-blue-dark);border:0;background:#ffffff85;box-shadow:none}#substance-matrix-app .pms-reference-hero{gap:16px;padding:2px 0 10px}#substance-matrix-app .pms-reference-hero-media{width:88px;height:88px}#substance-matrix-app .pms-reference-substance-hero .pms-reference-hero-media img{width:88px;height:88px;transform:scale(1.08)}#substance-matrix-app .pms-reference-hero .pms-reference-association{width:auto;height:88px;grid-template-columns:68px 22px 68px;gap:4px}#substance-matrix-app .pms-reference-hero .pms-reference-association img{width:68px;height:68px;transform:scale(1.08)}#substance-matrix-app .pms-reference-risk{gap:8px;padding:8px 10px;color:var(--pms-reference-risk-ink);border:1px solid var(--pms-reference-risk-border, rgba(6, 78, 232, .18));border-radius:10px;background:var(--pms-reference-risk-soft)}#substance-matrix-app .pms-reference-risk>svg{width:18px;height:18px;flex-basis:18px}#substance-matrix-app .pms-reference-risk strong{font-size:.875rem;font-weight:700}#substance-matrix-app .pms-reference-sheet-nav{gap:0;padding:6px 0;background:transparent;box-shadow:inset 0 -1px 0 var(--pms-reference-border);scrollbar-width:none}#substance-matrix-app .pms-reference-sheet-nav::-webkit-scrollbar{display:none}#substance-matrix-app .pms-reference-sheet-nav a,#substance-matrix-app .pms-reference-sheet-nav a.is-active{min-height:44px;padding:10px 12px 8px;color:#4e6076;border:0;border-bottom:3px solid transparent;border-radius:0;background:transparent;font-weight:600}#substance-matrix-app .pms-reference-sheet-nav a.is-active{color:var(--pms-reference-blue);border-bottom-color:var(--pms-reference-blue);font-weight:700}#substance-matrix-app .pms-reference-sheet-nav a:hover{color:var(--pms-reference-blue-dark);outline:none;outline-offset:0;background:#eaf1ffa3;box-shadow:none}#substance-matrix-app .pms-reference-sheet-nav a.is-active:hover{color:var(--pms-reference-blue);background:transparent}#substance-matrix-app .pms-reference-sheet-nav a:focus-visible{color:var(--pms-reference-blue-dark);outline:2px solid var(--pms-reference-blue-dark);outline-offset:-2px;background:#eaf1ffa3;box-shadow:none}#substance-matrix-app .pms-reference-section{padding:26px 30px;border:1px solid var(--pms-reference-border-subtle);border-radius:var(--pms-reference-radius-section);background:#fff;background:var(--pms-reference-surface);box-shadow:var(--pms-reference-shadow-section)}#substance-matrix-app .pms-reference-section h2,#substance-matrix-app .pms-reference-section summary{color:#173d70;font-weight:700}#substance-matrix-app .pms-reference-section-title-icon{width:22px;height:22px;flex-basis:22px;color:#356ab5;border-radius:0;background:transparent}#substance-matrix-app .pms-reference-section-title-icon svg{width:18px;height:18px}#substance-matrix-app .pms-reference-section.is-risques .pms-reference-section-title-icon{color:#a84727;background:transparent}#substance-matrix-app .pms-reference-section.is-takeaway{padding:24px 28px;border-color:#064ee82e;border-radius:var(--pms-reference-radius-lead);background:#fff;background:var(--pms-reference-surface-lead);box-shadow:0 2px 8px #2146880d}#substance-matrix-app .pms-reference-section.is-takeaway h2{margin-bottom:10px}#substance-matrix-app .pms-reference-section.is-help{border:1px solid rgba(6,78,232,.28);border-top:3px solid #5e95ed;background:var(--pms-reference-surface-help);box-shadow:0 4px 12px #2146880f}#substance-matrix-app .pms-reference-section.is-help .pms-reference-section-title-icon{width:28px;height:28px;flex-basis:28px;color:var(--pms-reference-blue);border-radius:8px;background:#dfeeff}#substance-matrix-app .pms-reference-risk-substance h3,#substance-matrix-app .pms-reference-risk-combination h3,#substance-matrix-app .pms-reference-section h3{font-weight:700}#substance-matrix-app .pms-reference-risk-combination{padding:18px 0 0;border:0;border-top:1px solid #f0cabc;border-radius:0;background:transparent}#substance-matrix-app .pms-reference-risk-combination h3{color:#8f2f13}#substance-matrix-app .pms-reference-risk-combination-icon{width:22px;height:22px;flex-basis:22px;color:#a84727;border-radius:0;background:transparent}#substance-matrix-app .pms-reference-risk-combination-icon svg{width:18px;height:18px}@media(max-width:700px){#substance-matrix-app .pms-reference-hero{gap:8px}#substance-matrix-app .pms-reference-hero-media,#substance-matrix-app .pms-reference-substance-hero .pms-reference-hero-media img{width:72px;height:72px}#substance-matrix-app .pms-reference-hero .pms-reference-association{height:72px;grid-template-columns:56px 20px 56px}#substance-matrix-app .pms-reference-hero .pms-reference-association img{width:56px;height:56px}#substance-matrix-app .pms-reference-section{padding:22px 20px;border-radius:16px}#substance-matrix-app .pms-reference-section.is-takeaway{padding:22px 20px}#substance-matrix-app .pms-reference-sheet-nav a,#substance-matrix-app .pms-reference-sheet-nav a.is-active{padding:10px 11px 8px}}@media(prefers-reduced-motion:reduce){#substance-matrix-app .pms-reference-substance-card,#substance-matrix-app .pms-reference-interaction-card,#substance-matrix-app .pms-reference-more-toggle{transition:none}}#substance-matrix-app .pms-reference-caution{display:grid;grid-template-columns:20px minmax(0,1fr);gap:10px;margin-top:18px;padding:14px 16px;border-left:3px solid #c97a80;border-radius:0 8px 8px 0;background:#faf0f1;color:#8d414c}#substance-matrix-app .pms-reference-caution.is-critical{border-left-color:#bb4d50;background:#fff1f0;color:#943c40}#substance-matrix-app .pms-reference-caution-icon{padding-top:3px}#substance-matrix-app .pms-reference-caution-icon svg{width:20px;height:20px}#substance-matrix-app .pms-reference-caution-title{display:block;margin-bottom:4px;font-weight:700}#substance-matrix-app .pms-reference-caution p{color:#514d49;font-size:.875rem;line-height:1.6}#substance-matrix-app .pms-reference-source-link{display:inline-flex;align-items:baseline;gap:8px;max-width:100%;margin-top:8px;color:#516478;font-size:.8125rem;font-weight:400;line-height:1.6;text-decoration:none;overflow-wrap:anywhere}#substance-matrix-app .pms-reference-source-link svg,#substance-matrix-app .pms-reference-article-placeholder svg{width:14px;height:14px;flex-shrink:0}#substance-matrix-app .pms-reference-source-link:hover{color:#193e65;text-decoration:underline;text-underline-offset:3px}#substance-matrix-app .pms-reference-source-link:focus-visible{outline:2px solid #5875e8;outline-offset:4px}#substance-matrix-app .pms-reference-article-placeholder{display:inline-flex;align-items:center;flex-wrap:wrap;gap:8px;color:#516478;font-weight:400}#substance-matrix-app .pms-reference-article-placeholder small{font-size:inherit;font-weight:400}#substance-matrix-app .pms-reference-more-content li .pms-reference-source-link,#substance-matrix-app .pms-reference-more-content li .pms-reference-article-placeholder{margin-top:0;font-size:inherit;line-height:inherit}#substance-matrix-app .pms-reference-resource-link{color:#3577ba;font-weight:500;text-decoration:underline;text-decoration-color:#9bc5ec;text-decoration-thickness:1px;text-underline-offset:3px}#substance-matrix-app .pms-reference-resource-link:hover{color:#174f87;text-decoration-color:currentColor}#substance-matrix-app .pms-reference-resource-link:focus-visible{outline:2px solid #5875e8;outline-offset:3px}#substance-matrix-app .pms-shell-reference{min-height:100vh;min-height:100dvh;background:radial-gradient(76% 48% at 0% 0%,#ffcc634d,#fff0 78%),radial-gradient(80% 56% at 100% 0%,#064ee84d,#997dff2e 44%,#fff0 80%),#f7f9fe}#substance-matrix-app .pms-reference-sheet-nav{padding-block:0;border-bottom:1px solid var(--pms-reference-border);box-shadow:none}#substance-matrix-app .pms-reference-sheet-nav a,#substance-matrix-app .pms-reference-sheet-nav a.is-active{position:relative;border-bottom:0}#substance-matrix-app .pms-reference-sheet-nav a.is-active:after{position:absolute;right:12px;bottom:-1px;left:12px;height:3px;content:"";background:var(--pms-reference-blue)}#substance-matrix-app .pms-reference-section.is-takeaway{padding:22px 26px;border-color:#064ee824;border-radius:14px;background:#f7faff;background:#f7faffd6;box-shadow:none}#substance-matrix-app .pms-reference-section.is-takeaway h2{margin-bottom:8px}#substance-matrix-app .pms-reference-section.is-takeaway p{color:#4a5870}#substance-matrix-app .pms-reference-section.is-help{margin-top:8px;border:1px solid rgba(6,78,232,.18);background:#f5faff;background:#f5fafff0;box-shadow:0 9px 24px #064ee814}#substance-matrix-app .pms-reference-directory .pms-reference-substance-card,#substance-matrix-app .pms-reference-directory .pms-reference-interaction-card{border-color:#064ee81f;border-radius:15px;background:#fff;box-shadow:0 2px 8px #2146880d}@supports ((-webkit-backdrop-filter: blur(1px)) or (backdrop-filter: blur(1px))){#substance-matrix-app .pms-reference-directory .pms-reference-substance-card,#substance-matrix-app .pms-reference-directory .pms-reference-interaction-card{background:#ffffffdb;-webkit-backdrop-filter:blur(8px);backdrop-filter:blur(8px)}}#substance-matrix-app .pms-reference-directory .pms-reference-interaction-card{padding-block:8px}#substance-matrix-app .pms-reference-directory .pms-reference-combo-item{gap:5px}#substance-matrix-app .pms-reference-sections{gap:24px}#substance-matrix-app .pms-reference-section>h2,#substance-matrix-app .pms-reference-section>summary{margin-bottom:14px}#substance-matrix-app .pms-reference-section.is-risques>h2{margin-bottom:14px}#substance-matrix-app .pms-reference-risk-substance+.pms-reference-risk-substance{border-left-color:#e4e7eb}#substance-matrix-app .pms-reference-risk-combination{border-top-color:#e7e4e2}#substance-matrix-app .pms-reference-hero .pms-reference-association{grid-template-columns:repeat(2,68px);gap:8px}@media(max-width:700px){#substance-matrix-app .pms-reference-hero .pms-reference-association{grid-template-columns:44px;grid-template-rows:repeat(2,44px);gap:4px;height:92px}#substance-matrix-app .pms-reference-sheet{gap:18px}#substance-matrix-app .pms-reference-sheet>.pms-reference-back:first-child{margin-bottom:-6px}#substance-matrix-app .pms-reference-hero{grid-template-columns:auto minmax(0,1fr);grid-template-areas:"media identity";align-items:center;gap:12px;padding:2px 0 4px}#substance-matrix-app .pms-reference-hero h1{letter-spacing:0;overflow-wrap:anywhere;text-wrap:pretty}#substance-matrix-app .pms-reference-hero-media{width:56px;height:56px;justify-self:start}#substance-matrix-app .pms-reference-substance-hero .pms-reference-hero-media img{width:56px;height:56px;transform:none}#substance-matrix-app .pms-reference-hero .pms-reference-association img{width:44px;height:44px;transform:none}#substance-matrix-app .pms-reference-section.is-takeaway{padding:18px 20px}#substance-matrix-app .pms-reference-sections{gap:18px}#substance-matrix-app .pms-reference-risk-substance+.pms-reference-risk-substance{border-top-color:#e4e7eb}}